β-Adenosine, a bioactive compound in grass chaff stimulating mushroom production

Domondon, D; He, Weidong; Kimpe, Norbert De; Höfte, Monica; Poppe, Joseph

doi:10.1016/j.phytochem.2003.11.004

Cited by 44 publications

(33 citation statements)

References 7 publications

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“…In particular, the fruiting in Pl. ostreatus has been shown to be induced by addition of veratryl alcohol (Suguimoto et al 2001), β-adenosine (Domondon et al 2004), phenol (Upadhyay and Hofrichter 1993), saponins (Magae 1999;Magae et al 2009), associated bacteria (Cho et al 2003), and some synthetic (Magae et al 2005) and natural (Berne et al 2008) surfactants. Analyses of the spatial and temporal expression of some fungal and bacterial aegerolysins have suggested their involvement in the initiation of fructification and/or sporulation.…”

Section: Activities Of the Aegerolysin Proteinsmentioning

confidence: 99%

Fungal aegerolysin-like proteins: distribution, activities, and applications

Novak

Kraševec

Skočaj

et al. 2014

Appl Microbiol Biotechnol

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The aegerolysin protein family (from aegerolysin of the mushroom Agrocybe aegerita) comprises proteins of ∼15-20 kDa from various eukaryotic and bacterial taxa. Aegerolysins are inconsistently distributed among fungal species, and variable numbers of homologs have been reported for species within the same genus. As such noncore proteins, without a member of a protein family in each of the sequenced fungi, they can give insight into different species-specific processes. Some aegerolysins have been reported to be hemolytically active against mammalian erythrocytes. However, some function as bi-component proteins that have membrane activity in concert with another protein that contains a membrane attack complex/perforin domain. The function of most of aegerolysins is unknown, although some have been suggested to have a role in development of the organism. Potential biotechnological applications of aegerolysins are already evident, despite the limited scientific knowledge available at present. Some mushroom aegerolysins, for example, can be used as markers to detect and label specific membrane lipids. Others can be used as biomarkers of fungal exposure, where their genes can serve as targets for detection of fungi and their progression during infectious diseases. Antibodies against aegerolysins can also be raised as immuno-diagnostic tools. Aegerolysins have been shown to serve as a species determination tool for fungal phytopathogen isolates in terms of some closely related species, where commonly used internal transcribed spacer barcoding has failed. Moreover, strong promoters that regulate aegerolysin genes can promote secretion of heterologous proteins from fungi and have been successfully applied in simultaneous multi-gene expression techniques.

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Section: Activities Of the Aegerolysin Proteinsmentioning

confidence: 99%

Fungal aegerolysin-like proteins: distribution, activities, and applications

Novak

Kraševec

Skočaj

et al. 2014

Appl Microbiol Biotechnol

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“…Mycelial densities of the fungus treated with all concentrations of adenosine were much higher than that of control. These effects were also found in other basidiomycetes, such as P. pulmonarius and S. rugosoannulata, and the concentrations of 0.012, 0.025, and 0.05 mg/ml adenosine significantly increased the mycelial aggregation of P. pulmonarius (Domondon et al 2004). Kubo and Mihara (2007) demonstrated that cAMP promotes mycelial branching in Mucor globosus.…”

mentioning

confidence: 61%

“…Moreover, Lou and Montag (1994) found that the dominant fraction of nucleosides in mushrooms is adenosine. Later on, Domondon et al (2004) revealed that adenosine acts as a biological elicitor to enhance mycelial growth in vitro and stimulates production of the edible mushrooms Pleurotus pulmonarius and Stropharia rugosoannulata. In view of these findings, we hypothesize that adenosine is essential and sufficient to stimulate the mycelial growth of ECM fungi.…”

mentioning

confidence: 99%

“…In a related study, Domondon et al (2004) extracted the adenosine from ryegrass (Lolium multiflorum) and showed that adenosine could act as an effective biological elicitor to stimulate the growth of P. pulmonarius and S. rugosoannulata. In this study, adenosine as investigated was effective in stimulating mycelial growth and branching of the S. luteus in pure culture without the host plant.…”

mentioning

confidence: 99%

“…Kubo and Mihara (2007) demonstrated that cAMP promotes mycelial branching in Mucor globosus. The reason suggested by Domondon et al (2004) was that there is a ready source for the synthesis of cAMP from adenine for mycelial cellular synthesis and growth.…”

mentioning

confidence: 99%

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Growth promotion of Suillus luteus by adenosine in vitro

2010

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In this work, adenosine has been shown to stimulate Suillus luteus mycelial growth, branching, and aggregates on solid substrate. Adenosine promoted S. luteus mycelial growth and branching, and the fungus responded significantly at a concentration as low as 0.01 mg/ml. The highest mycelial biomass and density of three strains were observed at 0.16 mg/ml in SNP-20, 0.08 mg/ml in SAF-501, and 0.16 mg/ml in PT-501. Adenosine enhanced mycelial aggregate at concentration of 0.02 mg/ml in SNP-20. The study suggests that adenosine promotes S. luteus mycelial growth, branching, and aggregation. Thus, it may be a good candidate as a biological elicitor of mycelial growth for S. luteus.

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Anti‐Neuroinflammatory Activity of New Naturally Occurring Benzylated Hydroxyacetophenone Analogs from the Endophytic Fungus Alternaria sp. J030

Jia¹,

et al. 2022

Chemistry & Biodiversity

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Chemical studies on the culture broth of the endophytic fungus Alternaria sp. J030 led to the identification of three benzylated hydroxyacetophenone derivatives, bauvaroalterins A -C (1 -3), and 34 structurally diverse metabolites (4 -37). The new structures were elucidated by extensive spectroscopic analyses including UV, IR, 1D and 2D NMR, HR-ESI-MS, and further confirmed using single crystal X-ray diffraction. The in vitro antineuroinflammatory effects of the co-isolated metabolites were evaluated in lipopolysaccharide (LPS)-stimulated microglial cells. Compounds 1-3 were shown to significantly reduce LPS-induced NO production by inhibiting the expression of iNOS, as well as inhibiting LPS-induced production of the inflammatory factors TNF-α, IL-1β and IL-6. Further studies revealed that 1-3 were capable of down-regulating the expression of NF-кB subunits p50 and p65, thereby suppressing the activation of NF-кB by inhibiting the LPS-induced phosphorylation of IкBα. Together these findings demonstrate that bauvaroalterins AÀ C (1 -3) exert anti-neuroinflammatory effects via inhibition of the NF-кB/iNOS signalling pathway in LPS induced BV-2 cells.

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β-Adenosine, a bioactive compound in grass chaff stimulating mushroom production

Cited by 44 publications

References 7 publications

Fungal aegerolysin-like proteins: distribution, activities, and applications

Fungal aegerolysin-like proteins: distribution, activities, and applications

Growth promotion of Suillus luteus by adenosine in vitro

Anti‐Neuroinflammatory Activity of New Naturally Occurring Benzylated Hydroxyacetophenone Analogs from the Endophytic Fungus Alternaria sp. J030

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