αB-crystallin in cerebrospinal fluid of patients with multiple sclerosis

Stoevring, Birgitte; Vang, Ole; Christiansen, Michael

doi:10.1016/j.cccn.2005.01.034

Cited by 24 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, Cryab, which is a component of brain myelin, was found as the most abundant unique transcript in MS plaques. Furthermore, it has been shown that peripheral blood mononuclear cells from MS patients contain large amounts of Cryab specific auto-reactive T cells (22)(23)(24)(25). Recently, however, a protective role of Cryab during experimental autoimmune encephalomyelitis, the animal model mirroring MS, has been published (26).…”

Section: Discussionmentioning

confidence: 99%

“…However, whether the specific role of Cryab is beneficial or, rather, detrimental to this pathology is still a matter of debate (22)(23)(24)(25)(26). Furthermore, a potential role of crystallins during axonal regeneration has also been recently reported (27,28).…”

Section: Multiple Sclerosis (Ms)mentioning

confidence: 99%

“…Given the controversial role of the small heat shock protein Cryab in the pathology of MS (22)(23)(24)(25)(26) and despite the fact that its corresponding gene was not revealed in the present microarray study, we performed qPCR analysis using specific primers for Cryab in the same samples used for the microarray study. Interestingly, Cryab was down-regulated by all the stimuli investigated (Fig.…”

Section: Systems Biology Approach To Identify Genes and Pathwaysmentioning

confidence: 99%

See 2 more Smart Citations

Functional Whole-genome Analysis Identifies Polo-like Kinase 2 and Poliovirus Receptor as Essential for Neuronal Differentiation Upstream of the Negative Regulator αB-crystallin

Draghetti

Salvat

Zanoguera

et al. 2009

Journal of Biological Chemistry

View full text Add to dashboard Cite

This study aimed at identifying transcriptional changes associated to neuronal differentiation induced by six distinct stimuli using whole-genome microarray hybridization analysis. Bioinformatics analyses revealed the clustering of these six stimuli into two categories, suggesting separate gene/pathway dependence. Treatment with specific inhibitors demonstrated the requirement of both Janus kinase and microtubule-associated protein kinase activation to trigger differentiation with nerve growth factor (NGF) and dibutyryl cAMP. Conversely, activation of protein kinase A, phosphatidylinositol-3-kinase ␣, and mammalian target of rapamycin, although required for dibutyryl cAMP-induced differentiation, exerted a negative feedback on NGF-induced differentiation. We identified Polo-like kinase 2 (Plk2) and poliovirus receptor (PVR) as indispensable for NGF-driven neuronal differentiation and ␣B-crystallin (Cryab) as an inhibitor of this process. Silencing of Plk2 or PVR blocked NGF-triggered differentiation and Cryab down-regulation, while silencing of Cryab enhanced NGF-induced differentiation. Our results position both Plk2 and PVR upstream of the negative regulator Cryab in the pathway(s) leading to neuronal differentiation triggered by NGF.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Multiple Sclerosis (Ms)mentioning

confidence: 99%

Section: Systems Biology Approach To Identify Genes and Pathwaysmentioning

confidence: 99%

See 1 more Smart Citation

Functional Whole-genome Analysis Identifies Polo-like Kinase 2 and Poliovirus Receptor as Essential for Neuronal Differentiation Upstream of the Negative Regulator αB-crystallin

Draghetti

Salvat

Zanoguera

et al. 2009

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…As a result, CRYAB Ϫ/Ϫ mice show worse EAE (13). Antibodies against CRYAB are present in the cerebrospinal fluid of MS patients and in the serum from EAE mice (14).…”

Section: Msmentioning

confidence: 99%

Inflammatory Proprotein Convertase-Matrix Metalloproteinase Proteolytic Pathway in Antigen-presenting Cells as a Step to Autoimmune Multiple Sclerosis

Shiryaev¹,

Remacle²,

Savinov³

et al. 2009

Journal of Biological Chemistry

View full text Add to dashboard Cite

“…HSP-27 antibodies may serve as a marker of disease activation if these results can be confirmed by others. Another HSP, α,β-crystallin, is present in the cerebrospinal fluid of MS patients [32]. However, antibodies to α,β-crystallin are found in the serum of both MS patients and healthy controls [33].…”

Section: Hsps In Multiple Sclerosismentioning

confidence: 99%

Heat-Shock Proteins in Clinical Neurology

2011

View full text Add to dashboard Cite

Heat-shock proteins (HSPs) are antigen-presenting protein-aggregation-preventing chaperones, induced by cellular stress in eukaryotic cells. In this review, we focus on recent HSP advances in neurological disorders. In myasthenia gravis, patients responding to immunosuppressive therapy have reduced serum HSP-71 antibodies. Generalized and ocular myasthenia gravis patients have elevated serum HSP-70 antibodies, indicating common pathogenic mechanisms. In Guillain-Barré syndrome, HSP-70 antibodies are elevated in serum and cerebrospinal fluid, and serum levels are higher than in myasthenia gravis and multiple sclerosis. In multiple sclerosis, serum HSP-27 antibodies are elevated during relapses providing disease activation marker, while α,β-crystallin expression in brain lesions indicates remission phase initiation. In acute stroke, serum HSP-27 antibodies are elevated irrespective of stroke type and duration. In epilepsy, HSP-27 is induced in patients’ astrocytes and cerebral blood vessel walls, and α,β-crystallin is expressed in epileptic foci. In neurodegenerative disorders such as Alzheimer dementia and Parkinson’s disease, HSPs are upregulated in brain tissue, and α,β-crystallin modulates superoxide dismutase-1 (SOD-1) tissue accumulation in familial amyotrophic lateral sclerosis. HSPs play an important role in antigen-presentation and tolerance development. Antibody-mediated interference with their function alters immune responses causing neuropathology. The role of HSPs in clinical neurology should be the subject of future investigation.

show abstract

αB-crystallin in cerebrospinal fluid of patients with multiple sclerosis

Cited by 24 publications

References 20 publications

Functional Whole-genome Analysis Identifies Polo-like Kinase 2 and Poliovirus Receptor as Essential for Neuronal Differentiation Upstream of the Negative Regulator αB-crystallin

Functional Whole-genome Analysis Identifies Polo-like Kinase 2 and Poliovirus Receptor as Essential for Neuronal Differentiation Upstream of the Negative Regulator αB-crystallin

Inflammatory Proprotein Convertase-Matrix Metalloproteinase Proteolytic Pathway in Antigen-presenting Cells as a Step to Autoimmune Multiple Sclerosis

Heat-Shock Proteins in Clinical Neurology

Contact Info

Product

Resources

About