α2A-adrenoceptors, but not nitric oxide, mediate the peripheral cardiac sympatho-inhibition of moxonidine

Cobos-Puc, Luis E.; Aguayo-Morales, Hilda; Belmares, Sonia Yesenia Silva; González-Zavala, María Antonia; Centurión, David

doi:10.1016/j.ejphar.2016.04.043

Cited by 9 publications

(1 citation statement)

References 42 publications

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“…Dexmedetomidine contains the imidazole ring, which has agonistic effects on α 2A and I 1 imidazoline receptors [ 19 ], inhibits cardiac sympathetic nerve activity, and converts rapid ventricular and supraventricular arrhythmias [ 20 ]. It inhibits the activity of voltage-gated sodion (Na + ) channel subtype α — Nav1.5 specifically expressed in cardiac tissues in a dose-dependent manner [ 21 ] to decrease the Na + channel continuous current (I Nap ) peak values under stress state, thus reduces effects on myocardial repolarization dispersion and the occurrence rates of malignant arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: a randomized controlled trial

et al. 2022

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Background Dexmedetomidine has controversial influence on cardiac electrophysiology. The aim of this study was to explore the effects of dexmedetomidine on perioperative cardiac electrophysiology in patients undergoing general anesthesia. Methods Eighty-one patients were randomly divided into four groups: groups D1, D2, D3 receiving dexmedetomidine 1, 1, 0.5 μg/kg over 10 min and 1, 0.5, 0.5 μg/kg/h continuous infusion respectively, and control group (group C) receiving normal saline. Twelve-lead electrocardiograms were recorded at the time before dexmedetomidine/normal saline infusion (T1), loading dose finish (T2), surgery ending (T6), 1 h (T7) after entering PACU, 24 h (T8), 48 h (T9), 72 h (T10) and 1 month (T11) postoperatively. Cardiac circulation efficiency (CCE) were also recorded. Results Compared with group C, QTc were significantly increased at T2 in groups D1 and D2 while decreased at T7 and T8 in group D3 (P < 0.05), iCEB were decreased at T8 (P < 0.05). Compared with group D1, QTc at T2, T6, T7, T9 and T10 and iCEB at T8 were decreased, and CCE at T2-T4 were increased in group D3 significantly (P < 0.05). Compared with group D2, QTc at T2 and iCEB at T8 were decreased and CCE at T2 and T3 were increased in group D3 significantly (P < 0.05). Conclusions Dexmedetomidine at a loading dose of 0.5 μg/kg and a maintenance dose of 0.5 μg/kg/h can maintain stability of cardiac electrophysiology during perioperative period and has no significant adverse effects on CCE. Trial registration ClinicalTrials.gov NCT04577430 (Date of registration: 06/10/2020).

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Section: Discussionmentioning

confidence: 99%