α2-Adrenoceptor Antagonists Reverse the 5-HT2 Receptor Antagonist Suppression of Head-Twitch Behavior in Mice

Matsumoto, Kinzo; Mizowaki, Maho; Thongpraditchote, Suchitra; Murakami, Yukihisa; Watanabe, Hiroshi

doi:10.1016/s0091-3057(96)00223-7

Cited by 14 publications

(9 citation statements)

References 17 publications

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“…In our previous study (Peričić et al 2001b), idazoxan (1 mg/ kg) and yohimbine (2 mg/kg) inhibited the anticonvulsant properties of swim stress, suggesting that swim stress inhibits the head twitch behaviour and enhances the doses of convulsants needed to produce convulsant signs and death by two separate and independent mechanisms. Our results showing that idazoxan failed to influence, while yohimbine produced a significant stimulation (29%) of 5-HTP-induced head twitch behaviour in unstressed mice, are partly in accordance with the previous studies showing that either one or both of these drugs stimulate the head twitch behaviour (Handley and Brown 1982;Heal et al 1986;Matsumoto et al 1997).…”

Section: Discussionsupporting

confidence: 92%

Swim stress inhibits 5-HT2A receptor-mediated head twitch behaviour in mice

Peričić

2003

Psychopharmacology

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Section: Discussionsupporting

confidence: 92%

Swim stress inhibits 5-HT2A receptor-mediated head twitch behaviour in mice

Peričić

2003

Psychopharmacology

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“…Moreover, the selective α 2 -adrenoceptor antagonist yohimbine prevents the effect of ketanserin and clonidine. The α 2 -adrenoceptor effect on the 5-HT 2 -receptor-induced head-twitch behaviour has been suggested to be mediated by post-synaptic site of central noradrenergic nerve terminals (Matsumoto et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Effect of noradrenergic system on the anxiolytic-like effect of DOI (5-HT2A/2C agonists) in the four-plate test

Massé¹,

Hascoët²,

Dailly³

et al. 2005

Psychopharmacology

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“…at an experimentally determined (see Results) non-sedating dose of 0.01 mg kg −1 , a dose also reported to be effective in suppressing seroMolecular Psychiatry tonergic drug-induced head-twitches. 31 Clonidine was administered in an injection volume of 10 ml kg −1 body weight. Mice were individually videotaped over 15 min, after 15 min of habituation to a new cage and 30 min after clonidine or placebo (i.p.…”

Section: Quantification Of Effect Of Clonidine On Tics and Locomotionmentioning

confidence: 99%

A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry

2002

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The tic disorder Tourette's Syndrome (TS) and obsessive-compulsive disorder (OCD) are comorbid behavioral disorders, suggesting a shared but still unknown neuronal basis. To 'circuit-test' such behaviors, we previously engineered transgenic mice expressing a neuropotentiating protein (cholera toxin A1 subunit) within a cortical-limbic subset of dopamine D1-receptor expressing (D1+) neurons known to trigger glutamatergic excitation of orbitofrontal, sensorimotor, limbic and efferent striatal circuits thought to be hyperactive or affected in OCD and TS. These mice exhibited OCD-like behaviors including generalized behavioral perseveration and compulsion-like leaping and grooming-associated pulling and biting of skin and hair. We now report that these OCD-like mice, like humans, also exhibit comorbid TS-like behaviors, including juvenile-onset tics; increased tic number, complexity and flurries; increased tic severity in males; voluntary tic suppression; and tic responsiveness to a non-cataleptic TS+OCD drug therapy (clonidine, 0.01 mg kg −1 ). These data suggest that hormonal gender differences, apart from the influence of genetic or autoimmune etiologic factors, may be sufficient to aggravate tic severity in human TS males compared to TS females. These data also proffer a precise neuronal basis for TS+OCD, wherein tics and primary compulsions or obsessions are evoked by hyperactivity of various cortical-limbic projection neurons' glutamatergic output to efferent targets like the striatum. The 'Cortical-limbic Glutamatergic Neuron' (CGN) neuronal circuit model merges formerly opposed neurotransmitter models of TS and OCD, and is consistent with new clinical reports of increased cortical hyperactivity, striatal glutamate and striatal inhibitory D2 receptors, and reduced striatal responsiveness, in these disorders.

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α2-Adrenoceptor Antagonists Reverse the 5-HT2 Receptor Antagonist Suppression of Head-Twitch Behavior in Mice

Cited by 14 publications

References 17 publications

Swim stress inhibits 5-HT2A receptor-mediated head twitch behaviour in mice

Swim stress inhibits 5-HT2A receptor-mediated head twitch behaviour in mice

Effect of noradrenergic system on the anxiolytic-like effect of DOI (5-HT2A/2C agonists) in the four-plate test

A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry

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