Α2-Adrenergic RECEPTORS: COMPARATIVE BIOCHEMISTRY OF NEURAL AND NON-NEURAL RECEPTORS, AND IN VITRO ANALYSIS IN PSYCHIATRIC PATIENTS

U’Prichard, David C.; Daiguji, Makoto; Tong, Ching; Mitrius, Joan; Meltzer, Herbert Y.

doi:10.1016/b978-0-08-027987-9.50026-3

Cited by 7 publications

(1 citation statement)

References 36 publications

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“…First, clonidine-induced growth hormone (GH) release (clonidine test), a neuroendocrinologic test which uses the ability of low cloni dine doses to stimulate G H secretion via interaction with cb-adrenoceptors located in hypothalamic areas. The clonidine test was widely used to characterize postsynaptic ot2-adrenoceptor function in the course of endog enous depression, where receptor sensitivity seems to be significantly reduced [6,7], Sec ond, human thrombocytes may be used as a source of a homogeneous population of func tional a 2-adrenoceptors [8] and the ob-adrenergic system of human thrombocytes was con sidered as a peripheral model for central neu rons bearing cb-adrenoceptors. Several stud ies reported significant changes of the number of cb-adrenoceptors on human platelets in the course of mental disorders, especially in en dogenously depressed patients [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Single and Repeated Clonidine Administration on the Properties of Central and Peripheral Alpha<sub>2</sub>-Adrenoceptors in Man

Schubert¹,

Stoll²,

Fleckenstein³

et al. 1993

Pharmacology

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The centrally acting α₂-adrenoceptor agonist clonidine was used to assess the sensitivity of α₂-adrenergic neurotransmis-sion in man, using receptor-binding studies and clonidine-induced growth hormone response. Neither acute (2 μg/kg body weight) nor subchronic (3 days, 2 × 150 μg/kg body weight) administration of clonidine affected platelet α₂-adrenoceptor number in humans as judged by ³H-yohimbine and ³H-UK-14,304 binding. The same treatment also did not modify central postsynaptic α₂-adrenoceptor function in the same individuals as assessed by clonidine-induced growth hormone responses. Similarly, subchronic (3 days, 500 μg/kg body weight, i.p.) or chronic (14 days, 500 μg/kg, i.p.) administration of clonidine to mice failed to change ³H-yohimbine or ³H-UK-14,304 binding sites in membranes prepared from frontal cortex. On the other hand, in vitro experiments using mouse frontal cortex or human platelet membranes showed pronounced reduction of ³H-UK-14,304 but not of ³H-yohimbine binding sites after incubation with several adrenoceptor agonists. The data indicate that acute and subchronic clonidine treatment may not change α₂-adrenoceptor sensitivity in humans or mice as assessed both at the functional and receptor level.

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Section: Introductionmentioning

confidence: 99%

Effects of Single and Repeated Clonidine Administration on the Properties of Central and Peripheral Alpha<sub>2</sub>-Adrenoceptors in Man

Schubert¹,

Stoll²,

Fleckenstein³

et al. 1993

Pharmacology

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Biological Studies of the Nosology of the Major Psychoses: A Status Report on the Schizoaffective Disorders

Meltzer

1986

Schizoaffective Psychoses

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Oxaprotiline: enantioselective noradrenaline uptake inhibition indicated by intravenous amine pressor tests but not ?2-adrenoceptor binding to intact platelets in man

Reimann¹,

Firkusny²,

Antonin³

et al. 1993

Eur J Clin Pharmacol

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The optically active isomers of the racemic tetracyclic antidepressant oxaprotiline, R (-) oxaprotiline CGP 12,103 A (levoprotiline) and the S (+) oxaprotiline CGP 12,104 A, have been used as tools for a methodological Phase I study. Only the S (+) enantiomer CGP 12,104 A inhibits noradrenaline uptake. Intravenous amine pressor tests and ex vivo measurement of alpha 2-adrenoceptor binding to intact human platelets were compared with respect to their reliability in indicating CGP 12,104 A-induced amine uptake inhibition and possibly associated alpha 2-receptor down-regulation in healthy subjects. alpha 2-Adrenoceptor binding on intact human platelets did not distinguish between CGP 12,104 and CGP 12,103 A. However, amine pressor tests reflected the amine uptake inhibiting effect of CGP 12,104 A as a 5-fold decrease in tyramine pressor sensitivity and a 5-fold increase in noradrenaline pressor sensitivity.

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Α2-Adrenergic RECEPTORS: COMPARATIVE BIOCHEMISTRY OF NEURAL AND NON-NEURAL RECEPTORS, AND IN VITRO ANALYSIS IN PSYCHIATRIC PATIENTS

Cited by 7 publications

References 36 publications

Effects of Single and Repeated Clonidine Administration on the Properties of Central and Peripheral Alpha<sub>2</sub>-Adrenoceptors in Man

Effects of Single and Repeated Clonidine Administration on the Properties of Central and Peripheral Alpha<sub>2</sub>-Adrenoceptors in Man

Biological Studies of the Nosology of the Major Psychoses: A Status Report on the Schizoaffective Disorders

Oxaprotiline: enantioselective noradrenaline uptake inhibition indicated by intravenous amine pressor tests but not ?2-adrenoceptor binding to intact platelets in man

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