α1-Acid glycoprotein induced effects in rat brain microvessel endothelial cells

Zhang, Shuangling; Mark, Karen S.

doi:10.1016/j.mvr.2012.05.003

Cited by 21 publications

(16 citation statements)

References 54 publications

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“…Many different activities, including modulating immunity, binding and carrying drugs, maintaining the barrier function of capillary, and mediating the sphingolipid metabolism 33 38 39 , have been attributed to ORM1. We found in this study that ORM1 increases muscle glycogen, whose level has been demonstrated in a variety of studies closely related to the endurance of skeletal muscles 26 40 .…”

Section: Discussionmentioning

confidence: 99%

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance

Hong

Sun

Luo

et al. 2016

Sci Rep

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Understanding and managing fatigue is a significant challenge in clinic and society. In attempting to explore how the body responds to and regulates fatigue, we found in rodent fatigue models that orosomucoid 1 (ORM1) was significantly increased in multiple tissues, including blood and muscle. Interestingly, administration of exogenous ORM1 increased muscle glycogen and enhanced muscle endurance, whereas ORM1 deficiency resulted in a significant decrease of muscle endurance both in vivo and in vitro, which could largely be restored by exogenous ORM1. Further studies demonstrated that ORM1 can bind to C-C chemokine receptor type 5 (CCR5) on muscle cells and deletion of the receptor abolished the effect of ORM1. Thus, fatigue upregulates the level of ORM1, which in turn functions as an anti-fatigue protein to enhance muscle endurance via the CCR5 pathway. Modulation of the level of ORM1 and CCR5 signaling could be a novel strategy for the management of fatigue.

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Section: Discussionmentioning

confidence: 99%

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance

Hong

Sun

Luo

et al. 2016

Sci Rep

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“…Orm has been identified as essential for the maintenance of stable solute permeability of microvessels by modulating the charge of microvessel walls (Schnitzer and Pinney, 1992). While the Orm modulated the permeability of BBB to charged molecules by adding negative charges to the matrix components of BBB (Yuan et al, 2010), it also increased the expression of tight junction proteins, such as occludin and zonula occludens to enhance BBB integrity (Zhang and Mark, 2012). One study demonstrated that exogenously administered Orm could mitigate brain edema and improve stroke outcomes (Muchitsch and Schwarz, 2003).…”

Section: Discussionmentioning

confidence: 99%

Orosomucoid1: Involved in vascular endothelial growth factor-induced blood–brain barrier leakage after ischemic stroke in mouse

Jiang

Zhu

et al. 2014

Brain Research Bulletin

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“…Alpha-1-acid glycoprotein is constitutively expressed by human microvascular endothelial cells [39]). Interestingly, previous studies identified alpha-1-acid glycoprotein as a protein, which alters the BBB integrity in inflammatoryrelated diseases [40][41][42]. Alpha-1-antichymotrypsin is a high abundant plasma protein that is synthesized by the liver and by trophoblast cells.…”

Section: Other Differentially Abundant Proteins In Csf Of Patients Wimentioning

confidence: 99%

Elevated levels of protein AMBP in cerebrospinal fluid of women with preeclampsia compared to normotensive pregnant women

Berg

Duvekot

Güzel³

et al. 2016

Prot. Clin. Appl.

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The current study showed a clear difference between the protein profiles of CSF from patients with PE and normotensive pregnant women. Protein AMBP is a precursor of a heme-binding protein that counteracts the damaging effects of free hemoglobin, which may be related to the presence of free hemoglobin in CSF. Protein levels showed correlations with clinical symptoms during pregnancy and postpartum. To our knowledge, this is the first LC-MS/MS proteome profiling study on a unique set of CSF samples from (severe) preeclamptic patients and normotensive pregnant women.

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α1-Acid glycoprotein induced effects in rat brain microvessel endothelial cells

Cited by 21 publications

References 54 publications

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance

Orosomucoid1: Involved in vascular endothelial growth factor-induced blood–brain barrier leakage after ischemic stroke in mouse

Elevated levels of protein AMBP in cerebrospinal fluid of women with preeclampsia compared to normotensive pregnant women

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