α,α-dihalocarbonyl compounds and their analogs in the Darzens reaction: An old reaction with new possibilities

Мамедов, В. А.; Мустакимова, Л. В.; Levin, Ya. A.; Tsuboi, Sadao

doi:10.1134/s2079978011010055

Cited by 2 publications

(1 citation statement)

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“…α,α‐Dihalocarbonyl compounds can also undergo the Darzens reaction with variety of carbonyl compounds in basic medium. A detailed discussion was reported by Mamedov group, in their recent review …”

Section: αα‐Dihaloketones As Building Blocks In Organic Synthesismentioning

confidence: 97%

The α,α‐Dihalocarbonyl Building Blocks: An Avenue for New Reaction Development in Organic Synthesis

Sadhukhan

Santhi

Baire

2020

Chemistry A European J

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The α,α‐dihalocarbonyl moiety is a bifunctional system with a gem‐dihalocarbon and a carbonyl carbon in 1,2‐fashion. This is one of the privileged scaffolds in medicinal chemistry due to its chemical and metabolic stability and lipophilicity. They have also been found in numerous structurally divergent natural products and most of their fabricated structures have already been in medicinal use. Apart from their important use in medicinal chemistry, the α,α‐dihalocarbonyl groups have been employed as key building blocks for the development of novel synthetic strategies and utilized as intermediates in total synthesis. In addition to the traditional transformations such as oxidations, reductions, and C−C bond formations, recently several new and non‐classical reactions have also been developed. This review provides short description of existing methods for their synthesis and detailed discussion on the efforts for the discovery and development of new reactions by employing α,α‐dihaloketones as synthetic building blocks. We have presented their use as key functional groups for the synthesis of polycyclic systems of medicinal and material importance and natural products.

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Section: αα‐Dihaloketones As Building Blocks In Organic Synthesismentioning

confidence: 97%