α‐tocopherol decreases interleukin‐1β and ‐6 and increases human β‐defensin‐1 and ‐2 secretion in human gingival fibroblasts stimulated with Porphyromonas gingivalis lipopolysaccharide

Abstract

These results suggest that α-tocopherol may play an active role in countering the damaging effect of LPS by reducing inflammatory cytokines, increasing β-defensins and promoting fibroblast growth, migration and wound healing.

Tumor Necrosis Factor‐α and Interleukin (IL)‐1β, IL‐6, and IL‐8 Impair In Vitro Migration and Induce Apoptosis of Gingival Fibroblasts and Epithelial Cells, Delaying Wound Healing

“…These results demonstrate the importance of modulation of inflammatory reactions on oral mucosa to accelerate closure of wounds. Regarding this modulation, some treatment strategies have been proposed, targeting modulation of inflammatory process 19 . Derradjia et al 19 demonstrated that application of α‐tocopherol to cells previously exposed to LPS stimulated cell viability and migration.…”

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

“…As a result, vitamin E may have anti-inflammatory effects against P. gingivalis. 164 Antibodies or antagonists There are also some antibodies or antagonists that indirectly influence IL-1β. Infliximab is a monoclonal antibody against TNF-α.…”

Ernährungsinterventionen bei chronischen Entzündungen

“…In einer In-vitro-Studie konnte gezeigt werden, dass die Applikation von Vitamin E (α-Tocopherol) die Bildung entzündungsfördernder Zytokine in humanen gingivalen Fibroblasten reduziert, wenn diese mit Lipopolysacchariden von Porphyromonas gingivalis konfrontiert werden [30]. In einer klinischen Studie korrelierte eine höhere…”