α-Tocopherol-ascorbic acid hybrid antioxidant based cationic amphiphile for gene delivery: Design, synthesis and transfection

Muripiti, Venkanna; Lohchania, Brijesh; Rachamalla, Hari Krishnareddy; Marepally, Srujan; Banerjee, Rajkumar; Patri, Srilakshmi V.

doi:10.1016/j.bioorg.2018.02.025

Cited by 24 publications

(15 citation statements)

References 46 publications

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“… 28 Muripiti et al. 161 disclosed that TE varied with the change of charge ratios, and charge ratios at 4:1 obtained the highest TE due to their least size of ~200 nm and optimal zeta potential. Sakai-Kato et al.…”

Section: Main Textmentioning

confidence: 99%

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Liu

Zhang

Zhu

et al. 2020

Molecular Therapy - Methods & Clinical Development

147

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Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors for decades with the advantages of excellent biodegradability, biocompatibility, and high nucleic acid encapsulation efficiency. However, the clinical use of CLs in cancer gene therapy is limited because of many uncertain factors in vivo . Extracellular barriers such as opsonization, rapid clearance by the reticuloendothelial system and poor tumor penetration, and intracellular barriers, including endosomal/lysosomal entrapped network and restricted diffusion to the nucleus, make CLs not the ideal vector for transferring extrinsic genes in the body. However, the obstacles in achieving productive therapeutic effects of nucleic acids can be addressed by tailoring the properties of CLs, which are influenced by lipid compositions and surface modification. This review focuses on the physiological barriers of CLs against cancer gene therapy and the effects of lipid compositions on governing transfection efficiency, and it briefly discusses the impacts of particle size, membrane charge density, and surface modification on the fate of CLs in vivo , which may provide guidance for their preclinical studies.

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Section: Main Textmentioning

confidence: 99%

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Liu

Zhang

Zhu

et al. 2020

Molecular Therapy - Methods & Clinical Development

147

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“…The leaves of strawberries are rich in tannic acid, ascorbic acid, and other bioactive compounds (Upadhyay and Mohan Rao, 2013 ). It has been reported that ascorbic acid is considered to be an antioxidant that has been proven to counteract the harmful effects that are related to reactive oxygen species (ROS)-induced injury (Muripiti et al, 2019 ). Strawberry leaves contain carotene and vitamin A, which can alleviate night blindness, maintain healthy epithelial tissues, improve eyesight, and promote growth and development.…”

Section: Introductionmentioning

confidence: 99%

Strawberry Leaf Extract Treatment Alleviates Cognitive Impairment by Activating Nrf2/HO-1 Signaling in Rats With Streptozotocin-Induced Diabetes

Zhang

Ma²,

Zhou

2020

Front. Aging Neurosci.

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Diabetes-associated cognitive impairment (DACI) is a common complication of diabetes mellitus (DM) that affects the central nervous system. Cognitive impairment, such as learning and memory impairment, and even dementia, is the main clinical manifestation of DACI. Unfortunately, there is no effective means by which to delay the cognitive symptoms of DM. Evidence has shown that strawberry leaf extract could alleviate cognitive decline, suppress oxidative stress, and reduce inflammatory responses in rats. In the present study, we evaluated the effect of strawberry leaf extract on cognitive function in a rat model of streptozotocin (STZ)-induced diabetes. After the continuous administration of strawberry leaf extract for 4 weeks, the Morris Water Maze (MWM) test results showed that the cognitive impairment of the rats was alleviated. Moreover, strawberry leaf extract significantly reduced the level of reactive oxygen species (ROS), decreased the level of malondialdehyde (MDA), improved the activity of superoxide dismutase (SOD) and catalase (CAT), decreased the mRNA expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and decreased the protein expression of caspase-3 and caspase-9 in the hippocampus of DM rats. Also, transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)/hemeoxygenase-1(HO-1) signaling was activated by the administration of strawberry leaf extract. Our findings indicate that strawberry leaf extract may be a potential drug candidate for the treatment of DACI and may be used as a basis for further research on the development of drugs for cognitive impairment in diabetes.

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“…Phenol, 2-naphthanol and guaiacol were readily converted to the corresponding hydroxyethylated products 1 a, 1 d and 1 e in high yields. On the other hand, the ethoxylation reaction of α-tocopherol, a highly sterically demanding substrate, took place at 180°C delivering 1 f [17] in excellent yield. The efficient synthesis of 1 g marked the compatibility of primary amide.…”

Section: Updates Ascwiley-vchdementioning

confidence: 99%

Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates

Kao¹,

Lin²,

Ryu

et al. 2019

Adv Synth Catal

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Described is a tetrabutylammonium fluoride-mediated hydroxyalkylation reaction of phenols with cyclic carbonates. This operationally simple method enables the synthesis of a variety of aryl β-hydroxyethyl ethers in good to excellent yields with a very small amount of catalyst loading (0.1-1 mol%). Of particular note is the efficient conversion of aromatic diols and phloroglucinol to the corresponding bis-and tris-hydroxyethylated products. To further showcase the versatility of this protocol, guaifenesin was prepared with a single step by the condensation of guaiacol and glycerol carbonate. We also developed a flow ethoxylation process permitting the continuous synthesis of multiflorol.

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α-Tocopherol-ascorbic acid hybrid antioxidant based cationic amphiphile for gene delivery: Design, synthesis and transfection

Cited by 24 publications

References 46 publications

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Strawberry Leaf Extract Treatment Alleviates Cognitive Impairment by Activating Nrf2/HO-1 Signaling in Rats With Streptozotocin-Induced Diabetes

Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates

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