1993
DOI: 10.1111/j.1365-2621.1993.tb06164.x
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α‐Tocopherol and Ascorbate Delay Oxymyoglobin and Phospholipid Oxidation In Vitro

Abstract: An oxymyoglobin liposome model was used to study the effects of a-tocopherol and/or ascorbate upon oxymyoglobin and lipid oxidation. Both oxidations were delayed (PcO.05) by increased concentrations of a-tocopherol alone and a-tocopherobascorbate relative to controls. The 14 )IM a-tocopheroV140 p,M ascorbate treatment resulted in greatest delay in both oxymyoglobin and lipid oxidation. Ascorbate alone delayed oxymyoglobin oxidation; effectiveness diminished as ascorbate increased. Ascorbate showed a prooxidant… Show more

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Cited by 148 publications
(85 citation statements)
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“…α-tocopherol acts as an antioxidant by donating a hydrogen atom to a free radical, and thus a stable α-tocopherol radical is formed (Yin et al, 1993).…”
Section: Resultsmentioning
confidence: 99%
“…α-tocopherol acts as an antioxidant by donating a hydrogen atom to a free radical, and thus a stable α-tocopherol radical is formed (Yin et al, 1993).…”
Section: Resultsmentioning
confidence: 99%
“…The oxidation of oxymyoglobin to metmyoglobin is a chemical process that causes discoloration (Schaefer, 2002). The formation of Met Mb from Oxy Mb is positively correlated to lipid oxidation (Yin et al, 1993). Free radicals are neutralized by antioxidants before lipid oxidation propagates among highly unsaturated fatty acid in cellular and subcellular membranes (Machlin, 1984).…”
Section: Chemical Analysismentioning
confidence: 99%
“…Thiobarbituric acid assay was employed for measuring the lipid oxidation (Yin et al, 1993). Briefly, duplicate 5 g samples were homogenized with 11% trichloroacetic acid in a blender.…”
Section: Methodsmentioning
confidence: 99%