α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study

Oliveira, Makson Gleydson Brito de; Brito, Renan Guedes de; Santos, Priscila L.; Araújo-Filho, Heitor G.; Quintans, Jullyana S. S.; Menezes, Paula P.; Serafini, Mairim Russo; Carvalho, Yasmim Maria Barbosa Gomes de; Silva, Juliane C.; Almeida, Jackson R.G.S.; Scotti, Luciana; Scotti, Marcus Tullius; Saravanan, S.; Thangaraj, Parimelazhagan; Araújo, Adriano A. S.; Quintans‐Júnior, Lucindo J.

doi:10.1016/j.cbi.2016.05.029

Cited by 55 publications

(38 citation statements)

References 51 publications

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“…Terpineol is found in pine trees, lilacs, eucalyptus, and lime blossoms, and used commonly in soap, perfume, and lotion. It reduced hyperalgesia in a chronic muscle pain fibromyalgia model presumably by affecting the opioid and serotonergic receptors . It has anti‐inflammatory and analgesic actions, antioxidant properties,anti‐proliferative and anti‐cancer effects especially in small cell lung carcinoma, antibacterial, antifungal, and antiviral effects.…”

Section: Terpenes (Terpenoids)mentioning

confidence: 99%

“…It reduced hyperalgesia in a chronic muscle pain fibromyalgia model presumably by affecting the opioid and serotonergic receptors . It has anti‐inflammatory and analgesic actions, antioxidant properties,anti‐proliferative and anti‐cancer effects especially in small cell lung carcinoma, antibacterial, antifungal, and antiviral effects. It also has skin penetration enhancing effects, airway smooth muscle relaxation in asthma, vasorelaxation and blood pressure reduction effects, and anxiolytic and sedative effects …”

Section: Terpenes (Terpenoids)mentioning

confidence: 99%

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Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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There is accumulating evidence for various therapeutic benefits of cannabis/cannabinoids, especially in the treatment of pain, which may also apply to the treatment of migraine and headache. There is also supporting evidence that cannabis may assist in opioid detoxification and weaning, thus making it a potential weapon in battling the opioid epidemic. Cannabis science is a rapidly evolving medical sector and industry with increasingly regulated production standards. Further research is anticipated to optimize breeding of strain-specific synergistic ratios of cannabinoids, terpenes, and other phytochemicals for predictable user effects, characteristics, and improved symptom and disease-targeted therapies.

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Section: Terpenes (Terpenoids)mentioning

confidence: 99%

Section: Terpenes (Terpenoids)mentioning

confidence: 99%

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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“…The authors observed an anti-hyperalgesic effect, possibly related to the action of α-terpineol on the opioid and serotonergic receptors; visualized with the use of naloxone and ondansetron antagonists; and confirmed by docking studies [31]. Similarly to citronellal, α-terpineol also showed antinociceptive effect in the capsaicin, glutamate, and formalin-induced orofacial Figure 4.…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 74%

“…In relation to FM, some classes of bioactive compounds extracted from medicinal plants have presented analgesic activity described in the literature, such as essential oils [24][25][26], extracts [27,28], monoterpenes [29][30][31], sesquiterpenes [32], saponins [33], and alkaloids ( Figure 1 and Table 2) [34]. * All preclinical studies used the chronic muscle pain model induced by acid saline.…”

Section: Introductionmentioning

confidence: 99%

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Brito¹,

Santos²,

AlmeidaOliveira³

et al. 2018

Discussions of Unusual Topics in Fibromyalgia

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Fibromyalgia (FM) is the second most common rheumatologic disorder, affecting 5% of the world population, and has a serious effect on the quality of life of patients, as well as an economic impact through lost workdays. This pain syndrome is a common cause of chronic widespread pain and is characterized by reduced pressure pain thresholds with hyperalgesia and allodynia, nonrestorative sleep, fatigue, cognitive dysfunction, and mood disturbances. The pharmacological treatment strategies for FM include the use of antidepressants, calcium channel modulators, muscle relaxants, and analgesics but have shown limited efficacy and therapeutic adherence. Thus, researchers have been seeking potential substances (new chemical entities or through drug repositioning) that could be used for FM treatment. In this context, natural products (NPs) have been shown to be promising pharmacological tools due to the variety of their pharmacological activity and the number of molecular sites available as possible active targets. Recent clinical and preclinical studies have been conducted to verify the possible applicability of NPs such as essential oils (EOs), plants extracts, terpenes, sapogenins, and alkaloids in the treatment of FM. The results have shown that natural products have an analgesic effect in different animal models of FM, probably by activation of inhibitory descending pathways, such as the periaqueductal gray and rostroventromedial medulla. Natural products and their secondary metabolites could therefore be a promising source for FM management. However, translational studies that seek to validate the preclinical studies are scarce, incipient, and lacking an approach focused on the traditional pharmaceutical market.

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“…Moreover, Trinh, (Trinh et al, 2011), also described the inhibition of the expression of proinflammatory cytokines and the reduced activation of NF-κB in lipopolysaccharide-stimulated peritoneal macrophages. Corroborating the anti-inflammatory and analgesic profiles of TPN, it has been shown to inhibit the production of proinflammatory cytokines (such as TNF-α) and modulate the central descending pain-inhibitory mechanism (de Oliveira et al, 2016;Quintans-Júnior et al, 2011).…”

Section: P-cymene (8) Is a Naturally Occurring Aromatic Organic Compomentioning

confidence: 99%

Monoterpenes modulating cytokines - A review

Quintans

Saravanan

Heimfarth

et al. 2019

Food and Chemical Toxicology

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Inflammatory response can be driven by cytokine production and is a pivotal target in the management of inflammatory diseases. Monoterpenes have shown that promising profile as agents which reduce the inflammatory process and also modulate the key chemical mediators of inflammation, such as pro and anti-inflammatory cytokines. The main interest focused on monoterpenes were to develop the analgesic and anti-inflammatory drugs. In this review, we summarized current knowledge on monoterpenes that produce anti-inflammatory effects by modulating the release of cytokines, as well as suggesting that which monoterpenoid molecules may be most effective in the treatment of inflammatory disease. Several different inflammatory markers were evaluated as a target of monoterpenes. The proinflammatory and antiinflammatory cytokines were found TNF-α, IL-1β, IL-2, IL-5, IL-4, IL-6, IL-8, IL-10, IL-12 IL-13, IL-17A, IFNγ, TGF-β1 and IFN-γ. Our review found evidence that NF-κB and MAPK signaling are important pathways for the anti-inflammatory action of monoterpenes. We found 24 monoterpenes that modulate the production of cytokines, which appears to be the major pharmacological mechanism these compounds possess in relation to the attenuation of inflammatory response. Despite the compelling evidence supporting the anti-inflammatory effect of monoterpenes, further studies are necessary to fully explore their potential as anti-inflammatory compounds.

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α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study

Cited by 55 publications

References 51 publications

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Monoterpenes modulating cytokines - A review

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