α-Synuclein modulates fibronectin expression in the trabecular meshwork independent of TGFβ2

Adulla, Anika; Patel, Urvi; Ashok, Ajay; Katiyar, Priya; Kaulakis, Mare; Kritikos, Alexander E; Pillai, Sachin; Lee, HyunPin; Lindner, Ewald; Rhee, Douglas J.; Singh, Neena

doi:10.1016/j.exer.2022.109351

Cited by 1 publication

(1 citation statement)

References 78 publications

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“…These studies found that ECM-related pathways were among the top-5 deregulated pathways in human cell lines that overexpressed alpha synuclein [ 69 , 70 ]. Additional interactions among ECM molecules and alpha synuclein have been documented in animal and in vitro studies [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ]. For instance, in a study of oligodendrocyte progenitor cells, overexpression of alpha synuclein led to integrin down-regulation that reduced adhesion to fibronectin and led to cell death [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Extracellular Matrix-Related Alterations in Parkinson’s Disease

Chapman,

Sorg

2024

Brain Sciences

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The role of the extracellular matrix (ECM) in Parkinson’s disease (PD) is not well understood, even though it is critical for neuronal structure and signaling. This systematic review identified the top deregulated ECM-related pathways in studies that used gene set enrichment analyses (GSEA) to document transcriptomic, proteomic, or genomic alterations in PD. PubMed and Google scholar were searched for transcriptomics, proteomics, or genomics studies that employed GSEA on data from PD tissues or cells and reported ECM-related pathways among the top-10 most enriched versus controls. Twenty-seven studies were included, two of which used multiple omics analyses. Transcriptomics and proteomics studies were conducted on a variety of tissue and cell types. Of the 17 transcriptomics studies (16 data sets), 13 identified one or more adhesion pathways in the top-10 deregulated gene sets or pathways, primarily related to cell adhesion and focal adhesion. Among the 8 proteomics studies, 5 identified altered overarching ECM gene sets or pathways among the top 10. Among the 4 genomics studies, 3 identified focal adhesion pathways among the top 10. The findings summarized here suggest that ECM organization/structure and cell adhesion (particularly focal adhesion) are altered in PD and should be the focus of future studies.

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