α-Synuclein Fibril, Ribbon and Fibril-91 Amyloid Polymorphs Generation for Structural Studies

A closer look at amyloid ligands, and what they tell us about protein aggregates

“…Amyloid structure is therefore not strictly dictated by the primary sequence of the polypeptide, but is instead a complex property that is dependent on environmental conditions during aggregation. 24,25,[27][28][29][30][31][32][33][34][35][36] A range of amyloid-binding ligands have been reported for studying and imaging amyloid fibrils. 3,[37][38][39][40][41][42][43][44][45][46] Amyloid-binding ligands are typically either fluorescent or radiolabelled to allow for binding to be detected and measured.…”

“…Amyloid structure is therefore not strictly dictated by the primary sequence of the polypeptide, but is instead a complex property that is dependent on environmental conditions during aggregation. 24,25,27–36…”