αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease
Angela Paterna,
Pamela Santonicola,
Giulia Di Prima
et al.
Abstract:According to the
amyloid hypothesis, in the early phases of Alzheimer’s
disease (AD), small soluble prefibrillar aggregates of the amyloid
β-peptide (Aβ) interact with neuronal membranes, causing
neural impairment. Such highly reactive and toxic species form spontaneously
and transiently in the amyloid building pathway. A therapeutic strategy
consists of the recruitment of these intermediates, thus preventing
aberrant interaction with membrane components (lipids and receptors),
which in turn may trigger a casc… Show more
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