α‐Polypeptide synthesis by the hydrogen‐migration polymerization of trans‐p‐nitrocinnamide

Solvent-Free Anionic Polymerization of Acrylamide: A Mechanistic Study for the Rapid and Controlled Synthesis of Polyamide-3

“…Their properties differ from other commercial polyamides due to a molecular structure made by only two methylene groups for one amide function and thus exhibit a capacity to uptake moisture, a glass transition temperature in the range 110–125 °C, a high melting temperature (320–355 °C), and a crystallinity (30–40%) depending on the precursor used and on the synthesis conditions. − Although PA-3 shows properties quite similar to that of silk, it has not been commercialized yet. Only a few applications of PA-3 and derivatives are referenced, such as a formaldehyde scavenger, poly­(oxymethylene) stabilizer, or antimicrobial polypeptide-like compounds. ,, At its earliest stages, Matlack and collaborators showed that polyamide-3 can be obtained by hydrogen transfer polymerization (HTP) of acrylamide. , This polymerization method was then further investigated ,,− and extended to acrylamide derivatives ,− or other compounds like maleimide, , cinnamide, , crotonamide, and methyl vinyl ketone . In the case of acrylamide, alkali precursors where shown to be the best candidates to get polyamide-3, but the discussion remained open for a while regarding the initiation step.…”

“…6,9,10 At its earliest stages, Matlack and collaborators showed that polyamide-3 can be obtained by hydrogen transfer polymerization (HTP) of acrylamide. 11,12 This polymerization method was then further investigated 3,8,13−22 and extended to acrylamide derivatives 1,23−28 or other compounds like maleimide, 29,30 cinnamide, 31,32 crotonamide, 33 and methyl vinyl ketone. 34 In the case of acrylamide, alkali precursors where shown to be the best candidates to get polyamide-3, but the discussion remained open for a while regarding the initiation step.…”