α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice

Matzuk, Martin M.; Finegold, Milton J.; Su, Jyan-Gwo J.; Hsueh, Aaron J. W.; Bradley, Allan

doi:10.1038/360313a0

Cited by 866 publications

(529 citation statements)

References 34 publications

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“…1A). Genomic DNA was prepared as described previously (Matzuk et al 1992). The 5' probe was generated from a region just 3' of the EcoRV site (Fig.…”

Section: Southern Blot and Pcr Analysis Of Targetingmentioning

confidence: 99%

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

Molkentin¹,

Lin²,

Duncan³

et al. 1997

Genes Dev.

1,058

773

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The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the expression of a number of cardiac-specific genes. To determine the role of GATA4 in embryogenesis, we generated mice homozygous for a GATA4 null allele. Homozygous GATA4 null mice arrested in development between E7.0 and E9.5 because of severe developmental abnormalities. Mutant embryos most notably lacked a primitive heart tube and foregut and developed partially outside the yolk sac. In the mutants, the two bilaterally symmetric promyocardial primordia failed to migrate ventrally but instead remained lateral and generated two independent heart tubes that contained differentiated cardiomyocytes. We show that these deformities resulted from a general loss in lateral to ventral folding throughout the embryo. GATA4 is most highly expressed within the precardiogenic splanchnic mesoderm at the posterior lip of the anterior intestinal portal, corresponding to the region of the embryo that undergoes ventral fusion. We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP.

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“…1A). Genomic DNA was prepared as described previously (Matzuk et al 1992). The 5' probe was generated from a region just 3' of the EcoRV site (Fig.…”

Section: Southern Blot and Pcr Analysis Of Targetingmentioning

confidence: 99%

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

Molkentin¹,

Lin²,

Duncan³

et al. 1997

Genes Dev.

1,058

773

View full text Add to dashboard Cite

show abstract

“…When the inhibin ␣-subunit is deleted from the germ line, inhibin-deficient mice develop gonadal sex cord-stromal tumors with a penetrance of 100% and ultimately die of a cachexia-like syndrome (91,92). To be able to exogenously control the expression of ␣-inhibin in transgenic mice, a progesteronebased binary mouse model was established.…”

Section: Conditional Gene Targetingmentioning

confidence: 99%

Of mice and models: improved animal models for biomedical research

Bockamp

Maringer

Spangenberg

et al. 2002

Physiological Genomics

147

109

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The ability to engineer the mouse genome has profoundly transformed biomedical research. During the last decade, conventional transgenic and gene knockout technologies have become invaluable experimental tools for modeling genetic disorders, assigning functions to genes, evaluating drugs and toxins, and by and large helping to answer fundamental questions in basic and applied research. In addition, the growing demand for more sophisticated murine models has also become increasingly evident. Good state-of-principle knowledge about the enormous potential of second-generation conditional mouse technology will be beneficial for any researcher interested in using these experimental tools. In this review we will focus on practice, pivotal principles, and progress in the rapidly expanding area of conditional mouse technology. The review will also present an internet compilation of available tetracycline-inducible mouse models as tools for biomedical research ( http://www.zmg.uni-mainz.de/tetmouse/ ).

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“…Activin reportedly induces terminal differentiation in K562 cells and limits their proliferation (Yu et al 1987), and a related protein, a-inhibin, is known to act as a tumorsuppressor gene in mice (Matzuk et al 1992). However, their receptors may or may not have similar functions.…”

mentioning

confidence: 99%

Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene

Ishikawa¹,

Kai²,

Murata³

et al. 1998

J Hum Genet

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Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30␣ kb of genomic DNA.

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α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice

Cited by 866 publications

References 34 publications

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

Of mice and models: improved animal models for biomedical research

Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene

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