α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress

Baeeri, Maryam; Bahadar, Haji; Rahimifard, Mahban; Navaei-Nigjeh, Mona; Khorasani, Reza; Rezvanfar, Mohammad Amin; Gholami, Mahdi; Abdollahi, Mohammad

doi:10.1016/j.phrs.2019.01.003

Cited by 36 publications

(26 citation statements)

References 59 publications

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“…Our test results of SOD and MDA found that SMCs in different dose groups can increase the SOD value of cells treated with ox-LDL and decrease the MDA value. SOD and MDA are classic indicators of oxidative stress evaluation, and there are currently reports in the literature that oxidative stress can promote cellular senescence [42][43][44]. Studies show that oxidative stress accelerate telomere shortening or dysfunction and telomere shortening suppresses cancer by triggering senescence in normal cells [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Shenqi Maixintong Capsule against ox‐LDL‐Induced Injury in RAW264.7 Macrophages

Liang

Cai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Shenqi Maixintong capsule (SMC), a traditional Chinese medicine compound, exerts various therapeutic effects, including nourishing one’s vitality, improving blood circulation, regulating vital energy, and promoting coronary circulation. Studies have demonstrated that SMC could effectively alleviate atherosclerosis (AS) and delay its development. However, the effect of SMC on lipid metabolism remains unclear. Herein, we investigated the mechanism of SMC on lipid metabolism of RAW264.7 cells induced by oxidized low-density lipoprotein (ox-LDL). Drug-containing serum was prepared by intragastric administration of SD (Sprague Dawley) rats. RAW264.7 cells were transformed into foam cells with 25 mg/L ox-LDL. SMC-treated rat serum increased the survival rate of ox-LDL-induced RAW264.7 cells. Oil Red staining, total cholesterol, and free cholesterol detection data showed that the intermediated dose of SMC had the best effect on reducing the lipid accumulation, lipid droplets, intracellular cholesterol, and total cholesterol content of RAW264.7 cells. The results of western blotting showed that the expression of ABCA1, ABCG1, LXRα, PPARγ, and peroxisome proliferation-activated receptor alpha (PPARα) was increased by SMC, and proprotein convertase subtilisin/kexin type 9 (PCSK9) was reduced, which promoted reverse cholesterol transport (RCT) of RAW264.7 cells and inhibited foam cell formation. Furthermore, SOD and MDA data indicated that SMC could reduce the senescence of RAW264.7 cells. These findings suggest that SMC might prevent ox-LDL-induced damage of macrophages in AS patients by improving cell viability and slowing down lipid accumulation and senescence.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Shenqi Maixintong Capsule against ox‐LDL‐Induced Injury in RAW264.7 Macrophages

Liang

Cai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Several in vitro studies have reported the effects of ALA in rat cell cultures [ 41 , 42 ] and CoQ10 in human cells [ 43 , 44 ], consistently showing decreased ROS production and inflammation, as well as an increase in thiol production and an improvement in ETC. Polyphenols can exert antioxidant or prooxidant effects depending on the oxygen and glucose levels used in the cell culture.…”

Section: Basic Research Studiesmentioning

confidence: 99%

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Pagano

Pallardó

Lyakhovich

et al. 2020

IJMS

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A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential–and distinct—roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs.

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“…Skin epidermis, a self‐regenerating organ, constantly sheds and replaces damaged and worn‐out skin cells (Orioli & Dellambra, ; Yang & Kang, ; Zhang et al, ). Although mitochondrial dysfunction adversely affects primarily nonregenerative tissue, the neuromuscular system, and internal organs, cells in every tissue type, including skin, require a continuous and adequate supply of mitochondrial energy for their survival and proper function (Baeeri et al, ; Dinkova‐Kostova, Kostov, & Kazantsev, ; Joshi & Mochly‐Rosen, ; Martinelli et al, ; Naidoo, Hanna, & Birch‐Machin, ; Wlaschek, Singh, Sindrilaru, Crisan, & Scharffetter‐Kochanek, ; Zhou et al, ). Representing the outermost surface of the body, skin is uniquely vulnerable to a plethora of environmental insults.…”

Section: Nrf2‐activating Therapeuticsmentioning

confidence: 99%

“…Some products are endogenously made, like the prostaglandins and L-carnitine as well as butyric, α-lipoic, fumaric, itaconic, and the nitro-fatty acids. However, most are phytochemicals (for example, sulforaphane comes from broccoli, resveratrol from grapes, tadehaginoside from Tadehagi triquetrum, curcumin from Curcuma longa plants, piperlongumine from Piper longum, and butein from the Japanese lacquer tree), metabolites and/or nutrients obtained from diet (olive oil included) or dietary supplements (Baeeri et al, 2019;Dinkova-Kostova, Fahey, Kostov, & Kensler, 2017;Dodson et al, 2019;Iranshahy et al, 2018;Nwanodi, 2018;Rigacci & Stefani, 2016;Vega et al, 2016;Wu et al, 2018). To achieve quantifiable therapeutic concentrations in the body, a select few were formulated and channeled through clinical trials for more rigorous evaluation (Ahmed, Luo, Namani, Wang, & Tang, 2017;Al-Sawaf et al, 2015;Cuadrado et al, 2019;Dinkova-Kostova et al, 2018;Dodson et al, 2019;Salehi et al, 2019;Vega et al, 2016).…”

Section: Nrf2-activating Therapeuticsmentioning

confidence: 99%

“…muscular system, and internal organs, cells in every tissue type, including skin, require a continuous and adequate supply of mitochondrial energy for their survival and proper function(Baeeri et al, 2019;Dinkova-Kostova, Kostov, & Kazantsev, 2018;Joshi & Mochly-Rosen, 2018;Martinelli et al, 2017;Naidoo, Hanna, & Birch-Machin, 2018; Wlaschek, Singh, Sindrilaru, Crisan, & Scharffetter-Kochanek, 2019;Zhou et al, 2018). Representing the outermost surface of the body, skin is uniquely vulnerable to a plethora of environmental insults.Exposure to harmful chemicals, xenobiotics, oxidative stress, and solar UV-radiation is mitigated by various protective mechanisms that rely on signaling networks and the expression of proteins involved in the detoxification of compounds or reactive oxygen speciesDodson et al, 2019;Hiebert et al, 2018;Jadkauskaite et al, 2017;Raghunath et al, 2018;Siegenthaler et al, 2018;Sivandzade, Prasad, Bhalerao, & Cucullo, 2019;Tonelli, Chio, & Tuveson, 2018;Vega, Krajisnik, Zhang, & Wondrak, 2017;Yamamoto, Kensler, & Motohashi, 2018).…”

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confidence: 99%

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Epigenetic treatment of dermatologic disorders

Moos

Faller

Glavas

et al. 2019

Drug Development Research

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Healthy skin protects us against a multitude of insults, but injured or maladapted skin can lead to infection, inflammation, or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and other plant and vegetable extracts, have shown utility in treating skin and related diseases as well as conditioning the skin to maintain its healthy function. Powerful agents targeting nuclear regulatory pathways continue to hold promise as new or repurposed therapies for a wide variety of ills and skin conditions. Epigenetic approaches that activate Nrf2 to effect detoxification, redox balance, DNA repair, and mitochondrial function are noteworthy. Some of the disease applications being actively investigated range from eczema and psoriasis to skin cancer and diabetes‐related wound healing to name just a few.

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α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress

Cited by 36 publications

References 59 publications

Protective Effect of Shenqi Maixintong Capsule against ox‐LDL‐Induced Injury in RAW264.7 Macrophages

Protective Effect of Shenqi Maixintong Capsule against ox‐LDL‐Induced Injury in RAW264.7 Macrophages

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Epigenetic treatment of dermatologic disorders

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