α-Lipoic acid loaded hollow gold nanoparticles designed for osteoporosis treatment: preparation, characterization and<i>in vitro</i>evaluation

Xi, Yanhai; Pan, Wenming; Liu, Yanyan; Xu, Guohua; Su, Yanguo; Chen, Daquan; Ye, Xiaojian

doi:10.1080/21691401.2022.2149542

Cited by 10 publications

(10 citation statements)

References 30 publications

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“…Yanhai Xi et al designed PEGylated hollow gold nanoparticles (HGNPs) loaded with α-Lipoic acid (ALA) (mPEG@HGNPs-ALA) [ 186 ]. ALA can suppress intracellular oxidative stress levels and promote the proliferation and differentiation of osteoblasts.…”

Section: Ros-scavenging Nanotechnology In Prevention and Treatment Of...mentioning

confidence: 99%

Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Dai,

Guo,

Tang

et al. 2024

J Nanobiotechnol

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With increasing proportion of the elderly in the population, age-related diseases (ARD) lead to a considerable healthcare burden to society. Prevention and treatment of ARD can decrease the negative impact of aging and the burden of disease. The aging rate is closely associated with the production of high levels of reactive oxygen species (ROS). ROS-mediated oxidative stress in aging triggers aging-related changes through lipid peroxidation, protein oxidation, and DNA oxidation. Antioxidants can control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing oxidative stress. Benefiting from significant advances in nanotechnology, a large number of nanomaterials with ROS-scavenging capabilities have been developed. ROS-scavenging nanomaterials can be divided into two categories: nanomaterials as carriers for delivering ROS-scavenging drugs, and nanomaterials themselves with ROS-scavenging activity. This study summarizes the current advances in ROS-scavenging nanomaterials for prevention and treatment of ARD, highlights the potential mechanisms of the nanomaterials used and discusses the challenges and prospects for their applications. Graphical Abstract

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Section: Ros-scavenging Nanotechnology In Prevention and Treatment Of...mentioning

confidence: 99%

Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Dai,

Guo,

Tang

et al. 2024

J Nanobiotechnol

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“…They successfully synthesized mPEG@HGNPs with a particle size of under 63 nm. It showed not only upregulation of the expression levels of BMP-2, Runx-2 and OCN to regulate osteoblast differentiation, but increased the viability of MC3T3-E1 cells as well as removed reactive oxygen species caused by H 2 O 2 injury, which has the prospect of treating osteoporosis [ 163 ]. Thus, many drugs and biomolecules can be applied on the GNPs and the use of GNPs can maximize both drug delivery and efficacy for treatment of osteoporosis.…”

Section: Incorporation and Functionalization Of Gnps For Bone Tissue ...mentioning

confidence: 99%

A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications

Yang,

Nah,

Lee

et al. 2024

Materials Today Bio

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“…Notably, LA plays a pivotal role in mitigating the detrimental effects of oxidative stress and apoptosis by scavenging reactive oxygen species (ROS) and protecting various cell types [20]. There is some evidence to suggest that LA has potential therapeutic bene ts for the treatment of osteoporosis [21,22]. Recent studies also indicate that the combination of natural antioxidants such as LA with gold nanomaterials may mitigate potential nanomaterial-associated toxicity [23].…”

Section: Introductionmentioning

confidence: 99%

Ångstrom-scale gold particles loaded with alendronate via alpha- lipoic acid alleviate bone loss in osteoporotic mice

Gao,

Li,

Shi

et al. 2024

Preprint

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Osteoporosis is a highly prevalent metabolic disease characterized by low systemic bone mass and deterioration of bone microarchitecture, resulting in reduced bone strength and increased fracture risk. Current treatment options for osteoporosis are limited by factors such as efficacy, cost, availability, side effects, and acceptability to patients. Gold nanoparticles show promise as an emerging osteoporosis therapy due to their osteogenic effects and ability to allow therapeutic delivery but have inherent constraints, such as low specificity and the potential for heavy metal accumulation in the body. This study reports the synthesis of ultrasmall gold particles almost reaching the Ångstrom (Ång) dimension. The antioxidant alpha-lipoic acid (LA) is used as a dispersant and stabilizer to coat Ångstrom-scale gold particles (AuÅPs). Alendronate (AL), an amino-bisphosphonate commonly used in drug therapy for osteoporosis, is conjugated through LA to the surface of AuÅPs, allowing targeted delivery to bone and enhancing antiresorptive therapeutic effects. In this study, alendronate-loaded Ångstrom-scale gold particles (AuÅPs-AL) were used for the first time to promote osteogenesis and alleviate bone loss through regulation of the WNT signaling pathway, as shown through in vitro tests. The in vivo therapeutic effects of AuÅPs-AL were demonstrated in an established osteoporosis mouse model. Microcomputed tomography, histology, and tartrate-resistant acid phosphatase staining indicated that AuÅPs-AL significantly improved bone density and prevented bone loss, with no evidence of nanoparticle-associated toxicity. These findings suggest the possible future application of AuÅPs-AL in osteoporosis therapy and point to the potential of developing new approaches for treating metabolic bone diseases using Ångstrom-scale gold particles.

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α-Lipoic acid loaded hollow gold nanoparticles designed for osteoporosis treatment: preparation, characterization andin vitroevaluation

Cited by 10 publications

References 30 publications

Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications

Ångstrom-scale gold particles loaded with alendronate via alpha- lipoic acid alleviate bone loss in osteoporotic mice

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