α-Lipoic acid chemistry: the past 70 years

Wang, Jia-Qi; Ling, Xu; Wang, Hui-Jing; Chen, Fen-Er

doi:10.1039/d3ra07140e

Cited by 3 publications

(4 citation statements)

References 80 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В процессе исследований взгляды на роль АЛК претерпевали значительные изменения. Если первоначально АЛК рассматривалась лишь в качестве незаменимого кофактора для митохондриальных ферментов, то с открытия ее антиоксидантного действия и до настоящего времени АЛК признается сильным антиоксидантом [3,19]. Большинство последующих исследований АЛК сосредоточено именно на изучении ее антиоксидантных свой ств.…”

Section: Introductionunclassified

Modern view on the use of alpha lipoic acid in neurological practice

Khaibullina,

Maksimov,

Khaibullina

2024

Medicinskij sovet

View full text Add to dashboard Cite

Alpha lipoic acid (ALA) is an essential cofactor for mitochondrial enzymes, a powerful antioxidant, and an important component of many metabolic processes. Most research on ALA has focused specifically on its antioxidant properties. A number of conditions – aging, atherosclerosis, liver cirrhosis, diabetes mellitus, various types of polyneuropathy, psoriasis and others can significantly reduce the level of ALA in the body. The article analyzes modern literature (107 sources, including 17 systematic reviews and meta-analyses). Traditionally, ALA is used in complex therapy of patients suffering from diabetic and alcoholic polyneuropathy. However, the analysis of studies conducted around the world is not limited to these two nosological forms. The use of ALA as adjuvant therapy for a number of conditions and diseases is justified, as confirmed by clinical studies, systematic reviews and meta-analyses. All studies assessed not only the effectiveness of ALC, but also its safety and the incidence of adverse events and showed that ALC has a high safety profile. ALA has not only a pronounced antioxidant effect, but also the ability to chelate toxic metals, increase intracellular glutathione levels, reduce blood glucose levels, overcome insulin resistance, participate in mitochondrial metabolism, stimulate the production of cAMP, normalize the lipid profile, reduce the level of inflammatory markers, etc. Based on Because of the positive effect of using ALC in the treatment of various symptoms and nosologies, the list of indications requires revision, expansion and addition.

show abstract

Section: Introductionunclassified

Modern view on the use of alpha lipoic acid in neurological practice

Khaibullina,

Maksimov,

Khaibullina

2024

Medicinskij sovet

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…To date, the extent to which each enantiomer contributes to α-lipoic acid pharmacological and toxicological effects is not fully understood. While it was proposed that S(-)-α-lipoic acid does not exhibit significant biological side effects [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], some studies indicated that it could potentially hinder the activity of the R(-)-enantiomer [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Structurally, it comprises three components: a five-atom dithiolate ring, an alkyl chain, and a terminal carboxylic acid (see Figure 1). The chiral centre at position C6 results in two enantiomers, R(+)-α-lipoic acid, the naturally available form, and S(-)-α-lipoic acid, which can be synthetically obtained [1]. R(+)-α-lipoic acid is generally recognized to exhibit superior activity compared to S(-)α-lipoic acid [2][3][4][5][6], even as α-lipoic acid is usually marketed as a racemic mixture containing both enantiomers.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

View full text Add to dashboard Cite

α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, and targeted delivery. Nanoformulations of α-lipoic acid can significantly enhance its solubility and absorption, making it more bioavailable. While α-lipoic acid can be prone to degradation in its free form, encapsulation within nanoparticles ensures its stability over time, and its release in a controlled and sustained manner to the targeted tissues and cells. In addition, α-lipoic acid can be combined with other compounds, such as other antioxidants, drugs, or nanomaterials, to create synergistic effects that enhance their overall therapeutic benefits or hinder their potential cytotoxicity. This review outlines the advantages and drawbacks associated with the use of α-lipoic acid, as well as various nanotechnological approaches employed to enhance its therapeutic effectiveness, whether alone or in combination with other bioactive agents. Furthermore, it describes the engineering of α-lipoic acid to produce poly(α-lipoic acid) nanoparticles, which hold promise as an effective drug delivery system.

show abstract

Liquid- and Semisolid-Filled Hard Gelatin Capsules Containing Alpha-Lipoic Acid as a Suitable Dosage Form for Compounding Medicines and Dietary Supplements

Jovičić-Bata,

Todorović,

Krstonošić

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Liquid-filled hard gelatin capsules may have pertinent advantages both for therapeutic effect and extemporaneous preparations of medicines. Alpha lipoic acid is a substance used in medicines and dietary supplements and there is a need for creating an appropriate formulation which would be suitable for each individual patient or consumer. Based on its biopharmaceutical and physical chemical characteristics, eight different capsule formulations were designed and characterized. Silicon dioxide was added to form a semisolid content and prevent leakage. The formulation filled with alpha lipoic acid solution in polyethylene glycol 400 showed the best performance. Although the addition of silicon dioxide to the formulation with polyethylene glycol 400 led to a change in both flow character and viscosity, the release rate did not show a statistically significant decrease (more than 85% of content was released after 5 min testing). Applied technique is a simple and an appropriate approach for compounding and could be used for other substances with similar properties.

show abstract

α-Lipoic acid chemistry: the past 70 years

Abstract: α-Lipoic acid (ALA) is a naturally occurring sulfur-containing fatty acid with high antioxidant activity.

Cited by 3 publications

References 80 publications

Modern view on the use of alpha lipoic acid in neurological practice

Modern view on the use of alpha lipoic acid in neurological practice

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Liquid- and Semisolid-Filled Hard Gelatin Capsules Containing Alpha-Lipoic Acid as a Suitable Dosage Form for Compounding Medicines and Dietary Supplements

Contact Info

Product

Resources

About