α-Linolenic Acid-Rich Flaxseed Oil Ingestion Increases Plasma Adiponectin Level in Rats

Abstract

Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. The effect of alpha-linolenic acid (ALA) on adiponectin has not been revealed. ALA is included abundantly in vegetable oils such as flaxseed oil. In this study, we attempted to clarify the effect of ALA-rich flaxseed oil (FSO) intake on the adiponectin level in rats. Seven-week-old male Sprague-Dawley rats were fed test diets containing high oleic safflower oil (HOSO) or FSO for 4 weeks. After the experimental period, the plasma adiponectin concentration in the FSO-fed group was higher than that in the HOSO-fed group. The adiponectin content of perirenal adipose tissue in the FSO-fed group was also significantly higher than that in the HOSO-fed group. However, the adiponectin mRNA level in the perirenal adipose tissue did not differ significantly between the HOSO-fed and FSO-fed groups. In this study, we clarified the effect of the ALA-rich FSO ingestion on the plasma adiponectin concentration in rats. It was suggested that the ALA-rich FSO intake might exhibit beneficial effects through an increase of the adiponectin level.

Differential effects of walnuts vs almonds on improving metabolic and endocrine parameters in PCOS

“…Experimental data have demonstrated that serum adiponectin correlated directly with oleic acid (MUFA in almonds) and LA (major PUFA in walnuts) in the adipocyte membrane (Perez de Heredia et al, 2009), as well as ALA (Sekine et al, 2008). Although adiponectin correlates with insulin sensitivity (Stefan and Stumvoll, 2002;Spranger et al, 2004), insulin sensitivity did not increase in our study.…”

Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats

“…In contrast, most studies have shown a reduction in the plasma concentration of adiponectin in obesity (see, e.g., [43]) with very few exceptions [44]. The possibility deserves to be considered that some fat components of the diet employed could be stimulus for adiponectin secretion in view that several nutraceutical products such as fish oil [45], safflower oil [46] or linoleic acid [47] increased adiponectin production in either animals or humans.…”

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

“…This seed, when used as a dietary supplement, has been shown to be beneficial in some pathological processes, as described in previous experimental studies (Hansen, 2006;Nies, Cymbala, Kasten, Lamprecht, & Olson, 2006;Paschos, Magkos, Panagiotakos, Votteas, & Zampelas, 2007;Sekine, Sasanuki, Murano, Aoyama, & Takeuchi, 2008). Flaxseed is a rich source of polyunsaturated fatty acids (PUFAS) and contains an average of 41% oil.…”