α‐Linolenic Acid Dietary Deficiency Alters Age‐Related Changes of Dopaminergic and Serotoninergic Neurotransmission in the Rat Frontal Cortex

Delion, Sylvie; Chalon, Sylvie; Guilloteau, Denis; Besnard, Jean‐Claude; Durand, Georges

doi:10.1046/j.1471-4159.1996.66041582.x

Cited by 307 publications

(150 citation statements)

References 15 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…an interaction between a-LA intake and neurotransmitters has been observed in animal experiments (Delion et al, 1996). a-Linolenic acid may influence depression via a mechanism that is different from that of DHA or EPA.…”

Section: Discussionmentioning

confidence: 90%

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

et al. 2004

View full text Add to dashboard Cite

The aim of the present study was to examine the association between daily omega-3 fatty acid intake and depression in Japanese cancer patients. Omega-3 fatty acid intake in 771 patients with newly diagnosed primary lung cancer was evaluated using a foodfrequency questionnaire, and the prevalence of depression was examined using the cutoff values for the depression subscale included in the Hospital Anxiety and Depression Scale. After adjustment for potential confounding factors, the odds ratio (OR) for depression among patients in the highest quartile of the total eicosapentaenoic acid-(C20:5n-3) and docosapentaenoic acid (C22:6n-3)-intake group compared with patients in the lowest quartile was not significantly different. On the other hand, the OR among the highest quartile of a-linolenic acid (C18:3n-3) intake (adjusted OR ¼ 0.50, 95% CI: 0.31 -0.71, P for trend ¼ 0.004) and the highest quartile of total omega-3 fatty acid intake (adjusted OR ¼ 0.55, 95% CI: 0.35 -0.88, P for trend ¼ 0.022) were significantly different. These results suggest that total eicosapentaenoic acid and docosapentaenoic acid intake might not be associated with depression in Japanese patients with newly diagnosed lung cancer, but that a-linolenic acid intake and total omega-3 fatty acid intake might be.

show abstract

Section: Discussionmentioning

confidence: 90%

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

et al. 2004

View full text Add to dashboard Cite

show abstract

“…This was probably due to reduced storage pools 97 , not due to decreased activity of monoamine oxidase 98 . Such effects of n-3 PUFA deficiency on serotonin concentrations are not found in all studies (for example, Delion et al 91,92 ).…”

Section: Findings and Mechanisms In Different Mammalsmentioning

confidence: 90%

Impact of nutrition on canine behaviour: current status and possible mechanisms

et al. 2007

View full text Add to dashboard Cite

Each year, millions of dogs worldwide are abandoned by their owners, relinquished to animal shelters, and euthanised because of behaviour problems. Nutrition is rarely considered as one of the possible contributing factors of problem behaviour. This contribution presents an overview of current knowledge on the influence of nutrition on canine behaviour and explores the underlying mechanisms by which diet may affect behaviour in animals. Behaviour is regulated by neurotransmitters and hormones, and changes in the availability of their precursors may influence behaviour. Tryptophan, the precursor of serotonin, may affect the incidence of aggression, selfmutilation and stress resistance. The latter may also be influenced by dietary tyrosine, a precursor to catecholamines. As diet composition, nutrient availability and nutrient interactions affect the availability of these precursors in the brain, behaviour or stress resistance may be affected. PUFA, especially DHA, have an important role as structural constituents in brain development, and dietary supply of n-3 and n-6 PUFA could modify aspects of the dopaminergic and serotonergic system and, consequently, cognitive performance and behaviour. Finally, persistent feeding motivation between meals can increase stereotyped behaviour and aggression and decrease resting time. This feeding motivation may be altered by dietary fibre content and source. At present, few studies have been conducted to evaluate the role of nutrition in canine (problem) behaviour through the above mentioned mechanisms. Studies that explore this relationship may help to improve the welfare of dogs and their owners.

show abstract

“…It is known that antidepressant drugs have a positive effect on PSD by mediating the signaling pathways of brain plasticity (Santarelli et al, 2003;Dranovsky and Hen, 2006). Neurogenesis and synaptogenesis associated with subchronic ALA treatment are strong arguments in favor of such mechanisms involved in the ALA-antidepressant effect, which can also be related to additive/or synergic interactions with serotonin, norepinephrine, or dopamine pathways (Delion et al, 1994(Delion et al, , 1996.…”

Section: Discussionmentioning

confidence: 99%

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke

Blondeau

Nguemeni

Debruyne

et al. 2009

Neuropsychopharmacol

117

View full text Add to dashboard Cite

Omega-3 polyunsaturated fatty acids are known to have therapeutic potential in several neurological and psychiatric disorders. However, the molecular mechanisms of action underlying these effects are not well elucidated. We previously showed that alpha-linolenic acid (ALA) reduced ischemic brain damage after a single treatment. To follow-up this finding, we investigated whether subchronic ALA treatment promoted neuronal plasticity. Three sequential injections with a neuroprotective dose of ALA increased neurogenesis and expression of key proteins involved in synaptic functions, namely, synaptophysin-1, VAMP-2, and SNAP-25, as well as proteins supporting glutamatergic neurotransmission, namely, V-GLUT1 and V-GLUT2. These effects were correlated with an increase in brain-derived neurotrophic factor (BDNF) protein levels, both in vitro using neural stem cells and hippocampal cultures and in vivo, after subchronic ALA treatment. Given that BDNF has antidepressant activity, this led us to test whether subchronic ALA treatment could produce antidepressant-like behavior. ALA-treated mice had significantly reduced measures of depressive-like behavior compared with vehicletreated animals, suggesting another aspect of ALA treatment that could stimulate functional stroke recovery by potentially combining acute neuroprotection with long-term repair/compensatory plasticity. Indeed, three sequential injections of ALA enhanced protection, either as a pretreatment, wherein it reduced post-ischemic infarct volume 24 h after a 1-hour occlusion of the middle cerebral artery or as post-treatment therapy, wherein it augmented animal survival rates by threefold 10 days after ischemia.

show abstract

α‐Linolenic Acid Dietary Deficiency Alters Age‐Related Changes of Dopaminergic and Serotoninergic Neurotransmission in the Rat Frontal Cortex

Cited by 307 publications

References 15 publications

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

Impact of nutrition on canine behaviour: current status and possible mechanisms

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke

Contact Info

Product

Resources

About