α-Klotho levels in girls with central precocious puberty: potential as a diagnostic and monitoring marker
Jun-Hong Park,
Eu-Seon Noh,
Il Tae Hwang
Abstract:BackgroundRecent studies suggest a link between the Klotho protein, sex hormones, and insulin-like growth factor-1 (IGF-1), indicating that α-Klotho levels may rise during puberty, including in central precocious puberty (CPP) cases. This study aimed to explore α-Klotho levels in girls with CPP to assess its potential as a diagnostic and monitoring tool for this condition.MethodsIn total, 139 girls, comprising 82 patients diagnosed with CPP and 57 healthy prepubertal controls, were enrolled in this study. From… Show more
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