α-Hydroxyketones as inhibitors of urease

Endophytic fungi from Nerium oleander L (Apocynaceae): main constituents and antioxidant activity

“…Chlorogenic acid, phenolic acid derivatives, and rutin possess a wide range of biological activities, such as antioxidant, antimutagenic, immunomodulatory, and antiviral activity (dos Santos et al 2005;Yu et al 2005). Biogenic volatile organic compounds are involved in multiple interorganism interactions and are also important in the flavor and fragrance, pesticide, and perfumery industries (Zini et al 2003), such as acetol (1-hydroxy-2-propanone) which has applications as a pharmaceutical and dye intermediate (Cameron and Cooney 1986) and recently has been reported as a potent inhibitor of urease (Tanaka et al 2004). Aliphatic constituents are frequently encountered as structural subunits in many natural products and some also have shown to be highly toxic towards fungi, bacteria, and mammalian cells, and to display neurotoxic, anti-inflammatory, nematicidal activities and anti-platelet-aggregatory effects (Nogueira et al 1996;Christensen and Brandt 2006).…”

Study on the Reactivity of Aldehydes in Electrolyzed Ionic Liquids: Benzoin Condensation – Volatile Organic Compounds (VOCs) vs. Room Temperature Ionic Liquids (RTILs)

“…For exemple, some fluorobenzoins are inhibitors of mammalian carboxylesterases, [16] while various a-hydroxy ketones are inhibitors of urease. [17] The importance of this class of compounds, therefore, has spurred the scientific community to elaborate new and efficient synthetic methodologies.…”

An efficient and convenient transformation of α-haloketones to α-hydroxyketones using cesium formate

“…General synthetic methods for their preparation include the irradiation a-haloketones under microwave [12] or under a high-pressure mercury lamp condition [13], a-hydroxylation of an enolate with a molybdenum peroxide [14][15][16][17] or the other oxidizing agents [18], transformation of the enamine derivatives by molecular oxygen [19], metallic-catalyzed oxidative transformation of olefins [20][21][22][23] and hydroxylation of silyl enol ether with m-chloroperbenzoic acid [24,25] or with certain oxidizing agents [26,27]. Most of the synthetic methodology could not provide satisfactory reaction conditions due to the expensive and special instruments required or the expensive and dangerous heavy metal oxidizing agents needed.…”