α-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae)

Mbaze, Luc Meva’a; Poumale, Hervé Martial Poumale; Wansi, Jean Duplex; Lado, Jean Alexandre; Khan, Shafqat Ullah; Iqbal, Muhammad Jawed; Ngadjui, Bonaventure T.; Laatsch, Hartmut

doi:10.1016/j.phytochem.2006.12.015

Cited by 78 publications

(57 citation statements)

References 12 publications

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“…Besides compound 2, compound 3 also showed a good alpha-glucosidase inhibitory activity followed by compound 1. Similar lupan-type triterpenes have been reported to exhibit alpha-glucosidase inhibitory activity 13 . In a different anti-diabetic assay model, betulinic acid was found to increase glucose uptake and enhanced glycogen synthesis 14 .…”

Section: Resultsmentioning

confidence: 57%

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves ofBuddleja salignaWilld

Chukwujekwu

Rengasamy

Kock

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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In our continuing search for biologically active natural product(s) of plant origin, Buddleja saligna, a South African medicinal plant, was screened in line with its traditional use for antidiabetic (yeast alpha glucosidase inhibitory) and antiplasmodial (against a chloroquine sensitive strain of Plasmodium falciparum (NF54)) activities. The hexane fraction showed the most promising activity with regards to its antidiabetic (IC 50 ¼ 260 ± 0.112 mg/ml) and antiplasmodial (IC 50 ¼ 8.5 ± 1.6 mg/ml) activities. Using activity guided fractionation three known terpenoids (betulonic acid, betulone and spinasterol) were isolated from this species for the first time. The compounds displayed varying levels of biological activities (antidiabetic: 27.31 mg/ml ! IC 50 ! 5.6 mg/ml; antiplasmodial: 14 mg/ml ! IC 50 ! 2 mg/ml) with very minimal toxicity.

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Section: Resultsmentioning

confidence: 57%

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves ofBuddleja salignaWilld

Chukwujekwu

Rengasamy

Kock

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Indonesia menempati posisi ketujuh negara dengan penderita diabetes terbanyak di dunia (IDF, 2013). Kumis kucing merupakan tanaman obat tradisional Indonesia yang digunakan untuk mengobati diabetes dengan cara menghambat aktivitas enzim pencernaan salah satunya enzim α-glukosidase (Mohamed et al, 2011;Mohamed et al, 2012). Selain anti hiperglikemik, tanaman kumis kucing kaya akan senyawa antioksidan (Akowuah et al, 2005) sehingga kumis kucing berpotensi pula untuk menurunkan risiko komplikasi diabetes akibat stres oksidatif (Baynes dan Thorpe, 1999).…”

Section: Pendahuluanunclassified

“…Fraksi kloroform kumis kucing diketahui mengandung terpenoid dan flavonoid termasuk sinensitin (Mohamed et al, 2011). Sinensitin merupakan senyawa metoksi flavonoid larut kloroform dengan aktivitas anti α-glukosidase kuat (IC 50 0,66 mg/mL) (Mohamed et al, 2012).…”

Section: Hasil Dan Pembahasan Aktivitas Penghambatan α-Glukosidase Ekunclassified

“…Asam hidroksibetulinat belum pernah dilaporkan memiliki aktivitas penghambatan terhadap enzim α-glukosidase akan tetapi pentasiklik triterpen asetat 3β-asetoksi-6β-asam hidroksibetulinat dari tanaman Fagara tessmannii Engl. menunjukkan aktivitas penghambatan yang signifikan terhadap enzim α-glukosidase (IC 50 7,6 μM) (Mbaze et al, 2007). Secara in vivo α-amirin dan β-amirin menunjukkan aktivitas antihiperglikemik pada konsentrasi 10, 30 dan 100 mg/kg terhadap mencit (Santos et al, 2012).…”

Section: Penanda Senyawa Penghambat Aktivitas Enzim α-Glukosidaseunclassified

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SENYAWA INHIBITOR Α-Glukosidase DAN ANTIOKSIDAN DARI KUMIS KUCING DENGAN PENDEKATAN METABOLOMIK BERBASIS FTIR

Juliani

Yuliana

Budijanto

et al. 2016

jtip

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Plant is well known as an excellent source for b ioactive compounds. Metab olomics was reported as a potential tool to accelerate plant acitive compounds identification. In this research, FTIR-b ased metab olomics method was used to identify active compounds with α-glucosidase inhib itory and antioxidant activity in aerial parts of Orthosiphon stamineus (OS OPLS). Based on the VIP (variab le influence on projection), the coefficient value of the respective OPLS models, and IR datab ase of compounds previously identified in OS, it was suggested that methoxy flavonoid (sinensitin and 5,6,7,3'-tetramethoxy-4'-hydroxy-8-C-preny-lflavone), diterpenes (orthosiphols, orthoarisins, neoorthosiphols, staminols, and stam inolactones) and triterpenes (ursolic acid, oleanolic acid, b etulinic acid, hydroxyb etulinic acid, maslinic acid, α-amyrin and β-amyrin) were identified as responsib le compounds for the α-glucosidase inhibitory activity. Meanwhile phenolic (rosmarinic acid ), methoxy flavonoid (eupatorin, sinensetin, 5-hydroxy-6,7,3',4'-tetramethoxyflavone, salvigenin, 6-hydroxy-5,7,3'-trimethoxyflavone and 5,6,7,3'-tetramethoxy-4'-hydroxy-8-C-prenylflavone), diterpenes (orthosiphols, orthoarisins, neoorthosiphols, staminols, and staminolactones) and triterpenes (ursolic acid, oleanolic acid, b etulinic acid, hydroxyb etulinic acid, maslinic acid, α-amyrin and β-amyrin) were identified as responsib le compounds for the antioxidant activity. Keywords: α-glucosidase inhib itors, antioxidants, metab olomics, Orthosiphon stamineus ABSTRAK1Tumbuhan merupakan salah satu sumber senyawa aktif yang potensial. Pendekatan metabolomik dilaporkan sebagai salah satu metode alternatif yang dapat mempercepat proses identifikasi komponen aktif dari tumbuhan. Pada penelitian ini, metode metabolomik berbasis FTIR digunakan untuk meng-identifikasi senyawa aktif dengan aktivitas penghambatan terhadap enzim α-glukosidase dan antioksidan pada ekstrak dan fraksi tanaman kumis kucing (OS). Profil kimia ekstrak metanolik dan fraksi heksana, kloroform, butanol, dan air OS diukur dengan FTIR. Ekstrak dan fraksi OS menunjukkan aktivitas penghambatan terhadap enzim α-glukosidase dengan nilai IC50 berkisar 154,07±30,60-465,83±85,34 µg/mL dan aktivitas antioksidan dengan nilai IC50 berkisar 7,41±0,02-19,35±0,09 µg/mL. Fraksi butanol adalah fraksi dengan aktivitas penghambatan α-glukosidase tertinggi dan aktivitas antioksidan menengah dengan nilai IC 50 berturut-turut turut 154,07±30,60 µg/mL dan 10,84±0,54 µg/mL. Korelasi antara data aktivitas biologis dan komposisi kimia dianalisis dengan orthogonal projections to latent structures (OPLS). Berdasarkan nilai VIP (variab le influence on projection), nilai koefisien dari model OPLS, dan pangkalan data IR senyawa yang telah teridentifikasi pada OS. Metoksi flavonoid (sinensitin dan 5,6,7,3'-tetrametoksi-4'-hidroksi-8-C-prenilflavon), diterpena (ortosifol, ortoarisin, neoortosifol, staminol, dan staminolakton), triterpena (asam ursolat, asam oleanolat, asam betulinat, asam hidroksibetulinat, ...

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“…2,6-dimethoxy-1,4-benzoquinone showed activities against seven of the nine strains employed, while 3β-acetoxy-16β-hydroxybetulinic acid showed weak activities against Bacillus subtilis and Escherichia coli, and 3β, 16β-hydroxybetulinic acid showed weak activities against Bacillus subtilis and Candida albicans (Mbaze et al, 2007).…”

Section: Antimicrobial Activitymentioning

confidence: 96%

Zanthoxylum Genus as Potential Source of Bioactive Compounds

Patiño¹,

Prieto²,

Cuca³

2012

Bioactive Compounds in Phytomedicine

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α-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae)

Cited by 78 publications

References 12 publications

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves ofBuddleja salignaWilld

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves ofBuddleja salignaWilld

SENYAWA INHIBITOR Α-Glukosidase DAN ANTIOKSIDAN DARI KUMIS KUCING DENGAN PENDEKATAN METABOLOMIK BERBASIS FTIR

Zanthoxylum Genus as Potential Source of Bioactive Compounds

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