α-Glucosidase inhibitory effect of resveratrol and piceatannol

Zhang, Albert J.; Rimando, Agnes M.; Mizuno, Cássia S.; Mathews, Suresh T.

doi:10.1016/j.jnutbio.2017.05.008

Cited by 74 publications

(69 citation statements)

References 44 publications

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“…Moreover, the variety of the extract constituents may result in different 291 affinities to react with different proteins[enzymes]. This is in agreement with many researches 293 polyphenols, flavonoids, terpenoids etc[31,32]. On the other hand, the current study of the 294 antimicrobial activity of the crude alcoholic extracts of E. tirucalli against some types of pathogens 295 has shown that it exhibited a low MIC against S. aureus and other bacteria under investigation.…”

supporting

confidence: 59%

Antioxidant, anti-enzymatic, antimicrobial and cytotoxic properties ofEuphorbia tirucalliL

Altamimi

Jaradat

Al-Lahham

et al. 2019

Preprint

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14 Medicinal properties of Euphorbia tirucalli L. have been investigated in vitro. Water extract from 15 the plant latex was freeze dried and tested against 3 digestive enzymes and showed IC50 as 16 39. 8±0.22, 79.43±0.38 and 316.22±0.3 for lipase, alpha-glucosidase and alpha-amylase, 17 respectively. These results were incomparable with drugs such as acarbose and orlistat.18 Antioxidant property showed that the IC50 values of E. tirucalli and Trolox were 79.43±0.69 and 19 3.1 ±0.92 respectively. Also, the plant extract exhibited a range of antimicrobial activity against 20 gram-positive and gram-negative bacteria and pathogenic yeast and fungi. Cytotoxicity of the plant 21 extract tested on Caco-2 cells was determined using MTT method. The effect was linear and almost 22 0.5 mg/ml extract has inhibited 50% of cells relative to the control. Euphorbia tirucalli showed 23 promising activities and is potential source of active ingredient with functional properties. 24 Key words: Euphorbia tirucalli L, bioactive properties, cytotoxicity, Caco-2. 25 Introduction 26 Phytogenic chemicals play an essential value in drugs investigations. Many of drug candidates and 27 clinically approved therapeutic agents have been isolated from plant products [1]. In fact, several 28 isolated molecules from herbal sources utilized in medicine, have the most potent therapeutic 29 activity among chemically produced medicines such as vincristine, taxol, atropine, morphine, 30 pilocarpine and many others [2]. The potent physiological and therapeutic effects of plant materials 31 usually resulted from the effects of plant secondary metabolic compounds. 32 Diabetes mellitus, obesity, and overweight are dangerous metabolic disorders and considered the 33 major reasons for mortality and morbidity for thousands of people in many of the developing 34 countries. However, different investigations demonstrated that obesity and overweight are 3 35 associated with an increased risk of diabetes. In fact, both of the obesity and overweight elevate 36 the costs of immense health care because they are significantly associated with diabetes, arthritis, 37 asthma, high level of blood cholesterol, high blood pressure and poor quality of life [3].38 Malignant tumor is commonly known as cancer which is a large group of diseases that may affect 39 every part of the human body with a rapid formation of abnormal cells and usually distributed to 40 other organs. However, the death from cancer usually occurred from the metastases process and 41 considered a second leading cause of death world widely. In 2018 cancer was responsible for about 42 9.6 million deaths with 70% of deaths were from middle-and low -income regions [4][5][6].43 Evidently, the anti-microbial resistance is a global medical and public health concern as it is not 44 limited to bacterial pathogens but also distributed to the parasites, fungi and viruses. Moreover, 45 the most therapeutically effective and safe drugs have already been developed, and newer effective 46 drugs often have more toxicity...

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supporting

confidence: 59%

Antioxidant, anti-enzymatic, antimicrobial and cytotoxic properties ofEuphorbia tirucalliL

Altamimi

Jaradat

Al-Lahham

et al. 2019

Preprint

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“…Previously, it has been reported that R. tomentosa fruit contains stilbenoid compound, such as resveratrol, and piceatannol [9]. These stilbenoids showed the more potent inhibition of α-glucosidase activity with IC50 91 and 60 µg/mL respectively than acarbose with IC50 247 µg/mL [5]. In addition, other phenolic compounds such as flavonoid isolated from Morus alba and anthocyanins isolated from noble muscadine grapes have been reported as a potential α-glucosidase inhibitory [16][17].…”

Section: ■ Results and Discussion The α-Glucosidase Inhibition Of Extmentioning

confidence: 99%

“…The αglucosidase inhibitor will interfere with the digestion of carbohydrate and thereby reduce the postprandial glucose level and insulin responses in a diabetic patient [2,4]. Acarbose, miglitol, and voglibose have been found as an α-glucosidase inhibitor and currently clinically used to control blood glucose of diabetic patients [5][6]. However, they have caused severe gastrointestinal side effects.…”

Section: ■ Introductionmentioning

confidence: 99%

α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>

et al. 2020

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One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC50 value of 20.57, 20.36 and 43.99 μg/mL respectively. The ethyl acetate and nbutanol fractions from the methanol extract of R. tomentosa fruit exhibited the potent inhibition (IC50 13.49 and 19.29 μg/mL) compare to acarbose and n-hexane fraction (IC50 383.68 and 1175.16 μg/mL). A leptospermone derivative, rhodomyrtosone D, was isolated from the ethyl acetate fraction of R. tomentosa fruit. The structure of rhodomyrtosone D was identified based on spectroscopic analysis, as well as comparing with literature data.The α-glucosidase inhibition of rhodomyrtosone D (IC50 110.45 μg/mL) was 3.5 fold more potent than acarbose. Thus, R. tomentosa plant could be potential as a natural resource of α-glucosidase inhibitor.

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“…The blockage of GI enzymes involved in carbohydrate and lipid metabolism may directly reduce their absorption. Studies have shown that resveratrol acts as an α‐glucosidase inhibitor in the mammalian α‐glucosidase activity and molecular docking assays . In HFD‐fed male C57BL/6 mice, administered resveratrol inhibited α‐glucosidase activity, which contributed to its ability to delay carbohydrates absorption in an oral carbohydrate challenge test, and thus resulted in a significant reduction of postprandial blood glucose .…”

Section: Mechanisms Of Anti‐obesity Effect Of Resveratrol and Pterostmentioning

confidence: 99%

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Pan

et al. 2018

BioFactors

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Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications. Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health. In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies. Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity. Although the efficacy of both compounds in humans requires further investigation with respect to their oral bioavailability, promising scientific findings have highlighted their potential as candidates for the treatment of obesity and the improvement of obesity-related metabolic diseases. © 2018 BioFactors, 44(1):50-60, 2018.

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α-Glucosidase inhibitory effect of resveratrol and piceatannol

Cited by 74 publications

References 44 publications

Antioxidant, anti-enzymatic, antimicrobial and cytotoxic properties ofEuphorbia tirucalliL

Antioxidant, anti-enzymatic, antimicrobial and cytotoxic properties ofEuphorbia tirucalliL

α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

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