α-Glucosidase inhibitory effect by the flower buds of Tussilago farfara L.

Gao, Hong; Huang, Yina; Gao, Bo; Xu, Peiyu; Inagaki, Chika; Kawabata, Jun

doi:10.1016/j.foodchem.2007.07.064

Cited by 117 publications

(84 citation statements)

References 22 publications

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“…Chebulagic acid was a reversible and noncompetitive inhibitor of intestinal maltase and a more potent inhibitor of maltase-glucoamylase complex than that of sucrase-isomaltase complex 28 . Compounds like 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid isolated from the flower buds of Tussilago farfara L. also inhibited intestinal maltase activity but with IC 50 value in mM range 29 . The Dixon plots and S/v vs I plots showed that nimbidiol inhibited various glucosidases in a mixed competitive fashion (Figures 2-5).…”

Section: Discussionmentioning

confidence: 99%

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

Mukherjee¹,

Sengupta²

2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Discussionmentioning

confidence: 99%

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

Mukherjee¹,

Sengupta²

2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…These samples represented natural populations of coltsfoot from different regions of Poland ( Fig. 1): Western Pomerania (localities 1-2), the Lubusz region (3), Greater Poland (4)(5)(6)(7)(8)(9)(10)(11)(12), Upper Silesia and Dąbrowa Basin (13)(14)(15), Lesser Poland (16)(17)(18), and the Cieszyn Silesia (19)(20). The investigated populations of T. farfara occurred in different types of habitats, mainly anthropogenic ones such as roadsides and roadside ditches as well as fallow lands.…”

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confidence: 99%

Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland

et al. 2013

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Coltsfoot (Tussilago farfara L.) is a common species, widely used in European and Chinese traditional medicine for the treatment of respiratory diseases. However, raw material from this plant contains hepatotoxic pyrrolizidine alkaloids (PAs). The aim of the study was to determine the variability of the level of PAs (senkirkine and senecionine) in leaves of coltsfoot originated from natural populations in Poland. In the phytochemical analysis, 20 samples of T. farfara were used. This plant material was obtained from the Garden of Medicinal Plants in Plewiska near Poznań and originated from different regions of Poland. Coltsfoot leaves were harvested in the middle of July of 2010 and then dried at room temperature. The alkaloid content was detected using the HPLC-DAD method. The amount of PAs in leaves of T. farfara changed in a wide range from 0.06 to 1.04 μg g−1 of dry matter (DM). The content of senkirkine and senecionine was positively correlated (r = 0.68, P = 0.001). There was no statistically significant correlation between the amount of PAs as well as leaf weight and water content in leaves of T. farfara. Our results showed that a medium-sized leaf of coltsfoot (0.33 g DM) may contain from 0.02 to 0.34 μg of PAs (on average 0.14 μg). The level of PAs was not associated with the region of Poland, but phytochemical similarity of samples was usually visible at the local scale. Coltsfoot leaves are characterized by a high variability of the content of toxic PAs, much higher than in the case of the main active compounds, especially flavonoids and mucilage. This phytochemical variability is mainly genetically determined (samples came from a garden collection), and it can be increased by environmental factors. Our investigations indicate that Polish natural populations of T. farfara may provide raw material with a low level of toxic PAs.

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“…asthma), acting as a weak platelet activating factor antagonist and a Ca 2+ channel blocker [17]. The extracts of Farfarae flos exhibit various activities, such as antioxidant [18,19], antiinflammatory [20] and antimicrobial [21][22][23]; what is more, they also inhibit some enzymes including α-glucosidase [24], NO synthetase in the LPS-activated macrophages or murine microglial cells [8,25] and diacylglycerol acyltransferase [26].…”

mentioning

confidence: 99%

Phenolics in the Tussilago farfara leaves

2013

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S u m m a r yColtsfoot leaves (Farfarae folium) are used in the European medicine in respiratory tract diseases, for cough, bronchitis and asthmatic disorders, while in the traditional Chinese medicine only flower buds (Farfarae flos) have been recognized as a medicine. A short literature review shows that most data concern the chemical composition of the coltsfoot flowers. During the carried out studies we have isolated and identified (UV, 1 H and 13 C NMR, analysis of acid and enzymatic hydrolyze products) six known flavonols from the coltsfoot leaves: kaempferol and its 3-O-β-glucopyranoside and 3-O-α-rhamnopyranosyl(1→6)-β-glucopyranoside, along with quercetin derivatives: 3-O-β-arabinopyranoside, 3-O-β-glucopyranoside and 3-O-α-rhamnopyranosyl(1→6)-β-glucopyranoside. Moreover, we have detected the presence of three phenolic acids.

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α-Glucosidase inhibitory effect by the flower buds of Tussilago farfara L.

Cited by 117 publications

References 22 publications

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland

Phenolics in the Tussilago farfara leaves

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