α-Foetoprotein in Rats with Hepatomas Induced by Aflatoxin B1

Rm, Kores; Jm, Sontag; Jh, Weisburger; Pm, Newberne; Gn, Wogan

doi:10.1038/240240a0

Cited by 24 publications

(2 citation statements)

References 7 publications

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“…It was initially thought that while other carcinogens such as 3'-methyl-4-dimethylaminoazobenzene in rats induced hepatomas which produced AFP, aflatoxin-induced tumors did n0t.22~3~ This apparent difference has since been found to be a function of aflatoxin B, dosage.16 In these earlier and subsequent studies, doses less than 2 ppm were incapable of inducing AFP-producing tumors, while higher doses (more than 4 ppm) resulted in AFP production. 16 It remains possible that a similar dose response curve may occur in humans, with lower doses of aflatoxin being c a p able of producing H C but no AFP, while larger doses produce both tumors and AFP. Against this hypothesis is the low frequency of AFP in older patients with HC, since these patients might logically be expected to have been exposed to a higher cumulative dose of carcinogen than younger patients.…”

Section: Discussionmentioning

confidence: 96%

Serum alpha-fetoprotein in 184 ugandan patients with hepatocellular carcinoma.Clinical, laboratory, and histopathologic correlations

Vogel

Primack

McIntire

et al. 1974

Cancer

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Qualitative serum alpha‐fetoprotein (AFP) determinations were done on sera from 184 Ugandan patients with hepatocellular carcinoma (HC) and the results correlated with clinical, laboratory, and histopathologic features of the disease. One hundred twenty‐one (66%) were AFP positive. Young patients and those with concomitant hepatitis B antigenemia (HBAg) were AFP positive significantly more frequently than older and HBAg negative patients. There were no differences in AFP frequency between patients with or without antibody to HBAg. There was also a tendency for men and patients with poorly‐differentiated tumors to be positive more frequently than women or patients with well‐differentiated tumors. No correlations with AFP elevation were found for duration of symptoms prior to diagnosis, disease stage, patient survival, standard tests of liver function, elevations of serum proline hydroxylase or serum chorionic gonadotropin, or the presence of concomitant cirrhosis. Sensitive, standardized, quantitative AFP tests should be used in future correlative studies with special emphasis placed on patient age and HBAg.

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Section: Discussionmentioning

confidence: 96%

Serum alpha-fetoprotein in 184 ugandan patients with hepatocellular carcinoma.Clinical, laboratory, and histopathologic correlations

Vogel

Primack

McIntire

et al. 1974

Cancer

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“…β) Διαιτητικοί παράγοντες δέν αποκλείεται νά ε πηρεάζουν τό έπίπεδον τής α, ΕΣ είς τ ίνας περιοχάς τής γής. Οι Alpert καί Kroes μετά τών συνεργατών των άναλύσαντες ύλικόν eg Αφρικανικών κυρίως χωρών υποθέτουν, ό τι πλην τών φυλετικών παραγόντων καί διαιτητικοί τοιού τοι δυνατόν νά παρεμβαίνουν είς τό ϋφος τής σ^ΕΣ είς τόν όρόν [16,95]. γ) Τό φϋλον πιθανόν νά έπηρεάζη τό ποσοοτόν> ανευ ρέσεως της α,ΕΤ: έπί αρωτοπαθοϋς καρκίνου τοϋ ήπατος.…”

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Ηπατοκυτταρικος Καρκινος Και Α1-Εμβρυικη Σφαιρινη. Παρατηρησεις Και Συμπερασματα Επι Του Ποσοτικου Κυριως Προσδιορισμου Ταυτης

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Effect of surgical and chemotherapeutic treatment on alpha-fetoprotein levels in patients with hepatocellular carcinoma

McIntire

Vogel

Primack

et al. 1976

Cancer

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Quantitative determinations of serum alpha-fetoprotein (AFP) by radioimmunoassay in 193 patients with hepatocellular carcinoma have demonstrated a wide variation in serum levels that appear to be relatively constant for each patient by the time that diagnosis is made. If there is no therapeutic intervention the serum AFP usually follows a gradual increase as the tumor progresses. A few patients have a fall i n serum AFP as a preterminal event.Various forms of chemotherapy cause only minor and transient decrease in serum AFP. Surgical resection of tumor produces an immediate fall that parallels the catabolic decay rate for AFP. All AFP-positive patients treated with surgery had recurrence of their tumor with a rise in serum AFP preceeding clinical discovery. The correlation of serum AFP and effective treatment is demonstration of the usefulness of this oncofetal protein marker as a n indicator of neoplastic activity for hepatocellular carcinoma and tumors with embryonal cell components and possibly for some other entodermally derived neoplasms.Cancer

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α-Foetoprotein in Rats with Hepatomas Induced by Aflatoxin B1

Cited by 24 publications

References 7 publications

Serum alpha-fetoprotein in 184 ugandan patients with hepatocellular carcinoma.Clinical, laboratory, and histopathologic correlations

Serum alpha-fetoprotein in 184 ugandan patients with hepatocellular carcinoma.Clinical, laboratory, and histopathologic correlations

Ηπατοκυτταρικος Καρκινος Και Α1-Εμβρυικη Σφαιρινη. Παρατηρησεις Και Συμπερασματα Επι Του Ποσοτικου Κυριως Προσδιορισμου Ταυτης

Effect of surgical and chemotherapeutic treatment on alpha-fetoprotein levels in patients with hepatocellular carcinoma

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