α-Fetoprotein-Producing (Hepatoid) Carcinoma of the Fallopian Tube

Aoyama, Tomomi; Mizuno, Toshihiko; Andoh, Katsuya; Takagi, Takasi; Mizuno, Toshihisa; Eimoto, Tadaaki

doi:10.1006/gyno.1996.0317

Cited by 23 publications

(16 citation statements)

References 1 publication

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“…Our patient had normal CEA serum concentrations,butthetumourcellswereweaklystainedby CEAinconcordancewiththeotherpublishedHACcaseof theperitonealcavity [15].Noticeablefordiagnosticreasonsis thepositivityforCEA,AFP,andCA125orthedetectionof elevatedserumlevelsofCA125inovarianHAC [21,29,[31][32][33][34][35][36].TheCEAstainingis,however,oflittlevaluefordifferentiationbetweenHACandHCC,asthemajorityofHCCare alsoCEA-positive [39].…”

Section: Resultssupporting

confidence: 46%

“…Oftheothertumourmarkers,especiallyCEAisoftenproducedbyHAC.PositivityforCEAwasobservedin50-100% of all published cases, occurring in all HAC of the pancreas [27,28],ovaries,andfallopiantube [21,[29][30][31][32][33][34][35][36],in86%ofthe gallbladdercases [10,22,23,37,38],andin51%ofthegastric HAC [7,8,10,11,24]. Our patient had normal CEA serum concentrations,butthetumourcellswereweaklystainedby CEAinconcordancewiththeotherpublishedHACcaseof theperitonealcavity [15].Noticeablefordiagnosticreasonsis thepositivityforCEA,AFP,andCA125orthedetectionof elevatedserumlevelsofCA125inovarianHAC [21,29,[31][32][33][34][35][36].TheCEAstainingis,however,oflittlevaluefordifferentiationbetweenHACandHCC,asthemajorityofHCCare alsoCEA-positive [39].…”

Section: Resultsmentioning

confidence: 99%

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Hepatoid Adenocarcinoma – Review of the Literature Illustrated by a Rare Case Originating in the Peritoneal Cavity

Metzgeroth¹,

Ströbel

Baumbusch³

et al. 2010

Onkologie

107

106

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Hepatoid adenocarcinoma (HAC) is a rare and aggressive extrahepatic tumour, morphologically mimicking hepatocellular carcinoma (HCC). However, immunophenotype and location are heterogeneous. We report the case of a 21-year-old man with HAC of the peritoneal cavity and summarize data from the 261 HAC cases published so far. The most common HAC locations were stomach (63%), ovaries (10%), lung (5%), gallbladder (4%), pancreas (4%), and uterus (4%). With the exception of gallbladder HAC, there was a male predominance (M:F = 2.4:1). Median age was 65 years (range 21–88). Fatigue, weight loss, abdominal masses, and pain were common findings. One-year survival was 55% and median overall survival 11 months (range 0.1–102). The outstanding diagnostic feature of HAC is positivity for alphafetoprotein (AFP) (88%), HepPar1 (63%), and EpCAM antibodies HEA125 or MOC31 which show no reactivity with hepatocytes. Due to the beneficial effect of sorafenib in HCC and strong activation of EGFR, ERK1 and AKT1, our patient received sorafenib. Despite temporary clinical improvement, he died 6 months after the diagnosis. The diagnostic panel of HAC should include AFP, HepPar1, and EpCAM antibodies. EpCAM reactivity excludes HCC. HAC has a poor prognosis.

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Section: Resultssupporting

confidence: 46%

Section: Resultsmentioning

confidence: 99%

Hepatoid Adenocarcinoma – Review of the Literature Illustrated by a Rare Case Originating in the Peritoneal Cavity

Metzgeroth¹,

Ströbel

Baumbusch³

et al. 2010

Onkologie

107

106

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show abstract

“…These tumors contained syncytiotrophoblast-like cells. Case reports about renin-producing or alpha fetoprotein (AFP)-producing tumors have been published (Aoyama al., 1996;Zabernigg et al, 1997). Fallopian tube carcinomas show frequent expression of CA-125 (Puls et al, 1993).…”

Section: Clinical Presentationmentioning

confidence: 99%

Fallopian tube tumors: an overview

Stein¹,

Diessner²,

Hönig³

et al. 2013

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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“…Hepatoid carcinoma (HC) is a neoplasm exhibiting features of hepatocellular carcinoma (HCC) in terms of morphology and immunohistochemistry which grows outside the liver [1,2,3]. The first case was reported by Ishikura et al [4] and concerned HC in the stomach.…”

Section: Introductionmentioning

confidence: 99%

“…The first case was reported by Ishikura et al [4] and concerned HC in the stomach. Since then, its occurrence has been described in gonadal yolk sac as well as in several non-germ cell origin primary sites, including esophagus, ampulla of Vater, colon, lung, gallbladder, adrenal gland, kidney, urinary bladder, ovary, uterus, vagina, and testicle [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16]. Microscopic ‘stigmata' of those origins are typically detectable in tumor focal areas.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Hepatoid Carcinoma: A Review of the Literature

Marchegiani¹,

Gareer²,

Parisi

et al. 2013

Dig Surg

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Background: Hepatoid carcinomas (HCs) are extrahepatic neoplasms exhibiting features of hepatocellular tumors in terms of morphology and immunohistochemistry. They have been described in several organs, most notably in the stomach and ovary. They can present in pure forms or in association with other morphological aspects, such as endocrine tumors or ductal adenocarcinomas. The aim of this review is to describe aspects of hepatoid adenocarcinoma of the pancreas with regard to epidemiology, diagnosis, and treatment. Methods: The PubMed database was searched for publications addressing hepatoid adenocarcinoma of the pancreas. We have searched for articles including the following keywords: ‘pancreatic hepatoid carcinoma', ‘ectopic liver cancer' and ‘rare pancreas neoplasm' published to date. As references, we used case reports and review articles. Results: Pancreatic forms of HCs are extremely uncommon: only 22 cases have been reported. Conclusions: The possibility of an HC of the pancreas should be considered in the differential diagnosis of an uncommon pathological mass of the pancreas. Treatment seems to be related to the association with other neoplasms, tumor extension at the time of diagnosis and the possibility to perform a radical resection. The common embryologic origin of the pancreas and liver, together with peculiar environmental factors, may explain the development of pancreatic HCs.

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α-Fetoprotein-Producing (Hepatoid) Carcinoma of the Fallopian Tube

Cited by 23 publications

References 1 publication

Hepatoid Adenocarcinoma – Review of the Literature Illustrated by a Rare Case Originating in the Peritoneal Cavity

Hepatoid Adenocarcinoma – Review of the Literature Illustrated by a Rare Case Originating in the Peritoneal Cavity

Fallopian tube tumors: an overview

Pancreatic Hepatoid Carcinoma: A Review of the Literature

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