α‐Difluoroalkylation of Benzyl Amines with Trifluoromethylarenes

Abstract

An α‐difluoroalkylation of benzyl amines with trifluoro‐methylarenes is disclosed herein. This protocol is characterized by its operational simplicity, excellent chemoselectivity and broad scope – even with advanced synthetic intermediates –, thus offering a new entry point to medicinally‐relevant α‐difluoroalkylated amines from simple, yet readily accessible, precursors.