α-d-Glucosidase inhibitory activity of polysaccharide isolated from Acacia tortilis gum exudate

Bisht, Swati; Kant, Ravi; Kumar, Vineet

doi:10.1016/j.ijbiomac.2013.04.057

Cited by 52 publications

(22 citation statements)

References 21 publications

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“…In this study, we successfully isolated a water-insoluble linear ␤-(1→3)-D-glucan (BYGlc) with purity of 99% from the crude Baker's yeast polysaccharides, and demonstrated that oral administration of BYGlc significantly downregulated the blood glucose level in T2D and DIO mice. Some studies have suggested that polysaccharides can act as an ␣-glycosidase inhibitor to slow down the digestion and absorption of glucose in small intestine [41,42], and increase the satiety feeling Figure 9. Effect of BYGlc on glucose transportation in cell models.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic activity of the Baker's yeast β-glucan in obese/type 2 diabetic mice and the underlying mechanism

Chen

Zou

et al. 2016

Mol. Nutr. Food Res.

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic activity of the Baker's yeast β-glucan in obese/type 2 diabetic mice and the underlying mechanism

Chen

Zou

et al. 2016

Mol. Nutr. Food Res.

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“…The inhibition of α ‐glucosidase has been studied as a new method to control type II diabetes (Shobana, Sreerama, & Malleshi, ). Furthermore, α ‐glucosidase inhibitors are utilized to delay the absorption of glucose, and have a significant effect on ameliorating type II diabetes symptoms such as hyperglycemia (Bisht, Kant, & Kumar, ). In the present study, α ‐glucosidase inhibitory activities of different batches of G. elata extracts were investigated.…”

Section: Resultsmentioning

confidence: 99%

Multicomponent quantitative analysis combined with antioxidant and alpha‐glucosidase inhibitory activities for the quality evaluation of Gastrodia elata from different regions

Gao

Miao

Guo

et al. 2019

Biomedical Chromatography

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Gastrodia elata (G. elata), as a natural plant with nourishing and edible value, plays a vital role in food and pharmaceutical production. In the present study, a novel approach for the simultaneous determination of six components based on high‐performance liquid chromatography (HPLC) coupled with photodiode array detection (PDA) was developed for the quality evaluation of G. elata from different regions. Meanwhile, antioxidant and α‐glucosidase inhibitory activities were estimated and compared. The results indicated that the total contents of the six compounds in G. elata from Guizhou and Zhejiang provinces obtained by boiling were higher than those obtained by steaming in Anhui and Yunnan provinces. In addition, samples from Guizhou, Yunnan and Shanxi provinces contained more p‐hydroxybenzyl alcohol, and always possessed higher antioxidant activity, while samples collected from Anhui province showed the highest α‐glucosidase inhibitory activity with the highest gastrodin content. The results revealed that the quality of G. elata was affected by different regions and different initial processing technologies, which provided a reference for the selection and application of G. elata.

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“…Levan polysaccharide is effective in the protection of liver, kidney, pancreas and heart tissue from the damage of alloxan-induced diabetic rats [15]. Moreover, polysaccharide from Acacia tortilis is also devoid of adverse effect like constipation, reduced high-density lipoprotein cholesterol, increased serum glutamic pyruvate transaminase for which acarbose is criticized clinically [16].…”

Section: Polysaccharidesmentioning

confidence: 99%

Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity

Chen¹

2017

JFNS

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Diabetes mellitus (DM), a group of chronic metabolic disorders characterized by hyperglycemia resulting from defects in insulin action and/or insulin secretion. It represents one of the main contributors to ill health and premature mortality worldwide and its prevalence has been rising during the last decades. Unfortunately, many antidiabetic agents for diabetes either have inadequate efficacy or significant mechanism-based side effects. A great deal of interest has been developed to the various natural bioactive compounds isolated and characterized from medicinal plants. This review focuses specifically on four nature phytochemicals such as polysaccharides, flavonoids, saponins and alkaloids whose properties are potencial to antidiabetic remedy.

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α-d-Glucosidase inhibitory activity of polysaccharide isolated from Acacia tortilis gum exudate

Cited by 52 publications

References 21 publications

Hypoglycemic activity of the Baker's yeast β-glucan in obese/type 2 diabetic mice and the underlying mechanism

Hypoglycemic activity of the Baker's yeast β-glucan in obese/type 2 diabetic mice and the underlying mechanism

Multicomponent quantitative analysis combined with antioxidant and alpha‐glucosidase inhibitory activities for the quality evaluation of Gastrodia elata from different regions

Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity

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