α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa

Costa, Rayssa H.F.; Krawczyk-Santos, Anna Paula; Andrade, Jayanaraian F. Martins; Barbalho, Geisa N.; Almeida, Rosane Mansan; Nóbrega, Yanna Karla de Medeiros; Cunha-Filho, Marcílio; Taveira, Stephânia Fleury; Gelfuso, Guilherme M.

doi:10.1016/j.carbpol.2022.120420

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…After 20 s, the membrane was carefully washed with a saline solution until the complete sample removal. Each chorioallantoic membrane was visually monitored and photographed for 5 min for hyperemia, hemorrhage, or clotting [ 35 , 36 ]. The irritation severity was classified as: 0 = no reaction, 1 = slight/mild, 2 = moderate, and 3 = severe for each time point (0.5, 2, and 5 min), which allowed for the classification of the irritability index (II) for each sample [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

Xavier

Matos

Barbalho

et al. 2023

Gels

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There is a growing interest in innovative products for eyebrow hair loss treatment with fewer adverse effects. Nevertheless, a fundamental formulation aspect of preventing the fragile skin from the ocular region from being irritated is that the formulations remain restricted to the application region and do not run off. Consequently, the methods and protocols in drug delivery scientific research must be adapted to fulfill such performance analysis demand. Thus, this work aimed to propose a novel protocol to evaluate the in vitro performance of a topical gel formulation with a reduced runoff for minoxidil (MXS) delivery to eyebrows. MXS was formulated with 16% poloxamer 407 (PLX) and 0.4% of hydroxypropyl methylcellulose (HPMC). The sol/gel transition temperature, viscosity at 25 °C, and formulation runoff distance on the skin were evaluated to characterize the formulation. The release profile and skin permeation were evaluated in Franz vertical diffusion cells for 12 h and compared to a control formulation (4% PLX and 0.7% HPMC). Then, the formulation’s performance at promoting minoxidil skin penetration with minimum runoff was evaluated in a vertical custom-made permeation template (divided into three areas: superior, middle, and inferior). The MXS release profile from the test formulation was comparable to that from the MXS solution and the control formulation. There was also no difference in the MXS amount that penetrated the skin in the permeation experiments in Franz diffusion cells using the different formulations (p > 0.05). However, the test formulation demonstrated a localized MXS delivery at the application site in the vertical permeation experiment. In conclusion, the proposed protocol could differentiate the test formulation from the control, attesting to its better performance in efficiently delivering MXS to the site of interest (middle third of application). The vertical protocol can be easily employed to evaluate other gels with a drip-free appeal.

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Section: Methodsmentioning

confidence: 99%

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

Xavier

Matos

Barbalho

et al. 2023

Gels

Self Cite

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“…58 CAM is a highly vascularized embryonic membrane, which responds similarly to vaginal, mucosal, or eye tissue. [59][60][61] The chemical irritation of new materials can be based on the nonphysiological pH, salt concentration, osmolarity, or toxicity to cells. Such an irritation effect after local application leads to undesirable pain, and an inflammatory process followed by tissue damage.…”

Section: Determination Of Safety Applicationmentioning

confidence: 99%

Influence of proline and hydroxyproline as antimicrobial and anticancer peptide components on the silver(i) ion activity: structural and biological evaluation with a new theoretical and experimental SAR approach

Kuzderová,

Sovová,

Rendošová

et al. 2024

Dalton Trans.

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“…In a recent report, Krawczyk-Santos and co-workers checked the possibility for the application of PPRs for vaginal antifungal delivery and noted positive results. 52 Arafa et al 53 explored mixed micellar systems of F127 and Gelucire® 44/14 for solubilising the drug praziquantel and observed high solubility, drug entrapment efficiency and prolonged release pattern for the optimized mixed micellar system. Shinde et al 54 explored the capacity of mixed micelles of Ge 48/16 and TPGS in solubilising hydrophobic anticancer drug, curcumin and observed improved solubility with mixed micelles than its individual components.…”

Section: Introductionmentioning

confidence: 99%

Molecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles Gelucire® 48/16 and Tetronics® 1304 in aqueous media

Bhalani,

Kakkad,

Modh

et al. 2023

RSC Adv.

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α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa

Cited by 4 publications

References 48 publications

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

Influence of proline and hydroxyproline as antimicrobial and anticancer peptide components on the silver(i) ion activity: structural and biological evaluation with a new theoretical and experimental SAR approach

Molecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles Gelucire® 48/16 and Tetronics® 1304 in aqueous media

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