α‐Chlorination of Acetophenones Using 1,3‐Dichloro‐5,5‐Dimethylhydantoin

Xu, Zijin; Zhang, Deyan; Zou, Xinzhuo

doi:10.1080/00397910500334637

Cited by 29 publications

(8 citation statements)

References 12 publications

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“…These reports are included -chlorination of acetophenones (Scheme 95) [111], oxidative cleavage of oximes [112,113] and oxidation of urazoles [114]. These reports are included -chlorination of acetophenones (Scheme 95) [111], oxidative cleavage of oximes [112,113] and oxidation of urazoles [114].…”

Section: 3-dichloro-55-dimethylhydantoinmentioning

confidence: 99%

Application of N-halo reagents in organic synthesis

Kolvari

Ghorbani‐Choghamarani

Salehi

et al. 2007

JICS

157

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This review article summarizes published data on the application of N-halo reagents (such as N-halo amines, N-halo amides and/or imides, N-halo sulfonamides and/or imides, and etc.) in various organic functional group transformations such as: oxidation reactions, deprotection and protection of different functional groups, halogenation of saturated and unsaturated compounds, acylation of alcohols, phenols, amines or thiols, epoxidation of alkenes, aziridination and etc. The main purpose of writing this review is encouraging of active researchers interested to this field for the synthesis of new N-halo reagents specially with different halogens and applications of these new N-halo reagents in organic reactions or finding more and more applications of existing N-halo reagents in organic synthesis.

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Section: 3-dichloro-55-dimethylhydantoinmentioning

confidence: 99%

Application of N-halo reagents in organic synthesis

Kolvari

Ghorbani‐Choghamarani

Salehi

et al. 2007

JICS

157

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“…29 1,3-dichloro-5,5dimethylhydantoin (DCDMH) (Fig. 1) is a stable, low cost and commercially available heterocycle which has rarely used as a source of chlorine ion or radical in chlorination 30,31 or oxidation reactions. 32,33 But, as our knowledge, there are no reports of catalytic application of DCDMH and TCCA in the synthesis of 1carbamato-alkyl-2-naphthols until now.…”

mentioning

confidence: 99%

Efficient preparation of some new 1-carbamato-alkyl-2-naphthols using N-halo reagents in neutral media

2014

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“…Synthesis of α-chloroketone dimethyl acetal (2); typical procedure Ketone 1 (0.5 mmol), Oxone ® (0.6 mmol), NH 4 Cl (1.0 mmol) and (HC(OMe) 3 ) (1.0 mmol) were added to MeOH (2 mL). The mixture was stirred at room temperature for 2 h and then the solvent was evaporated under reduced pressure.…”

Section: Methodsmentioning

confidence: 99%

A One-Pot Method Synthesis of α-Chloroketone Dimethyl Acetals

Zhou

2013

Journal of Chemical Research

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A new one-pot method has been developed for the direct preparation of α-chloroketone dimethyl acetals from ketones using ammonium chloride as the source of chlorine and potassium monoperoxysulfate as the oxidant in the presence of trimethyl orthoformate in methanol at room temperature. Ketones which have electron-withdrawing groups on the aryl rings gave the corresponding α-chloroketone dimethyl acetals in moderate to good yields.

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α‐Chlorination of Acetophenones Using 1,3‐Dichloro‐5,5‐Dimethylhydantoin

Cited by 29 publications

References 12 publications

Application of N-halo reagents in organic synthesis

Application of N-halo reagents in organic synthesis

Efficient preparation of some new 1-carbamato-alkyl-2-naphthols using N-halo reagents in neutral media

A One-Pot Method Synthesis of α-Chloroketone Dimethyl Acetals

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