α- and β-Adrenergic Receptors Differentially Modulate the Emission of Spontaneous and Amphetamine-Induced 50-kHz Ultrasonic Vocalizations in Adult Rats

Wright, Jennifer M.; Dobosiewicz, May; Clarke, Paul B. S.

doi:10.1038/npp.2011.258

Cited by 71 publications

(99 citation statements)

References 113 publications

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“…Indeed, as negotiating close-quarter contact, which occurs when one rat rolling over onto its back is attacked by another, appears to involve more sophisticated interanimal coordination than other tactics not involved in such close-quarter action (Pellis and Pellis, 1987;Bell et al, 2009), a reduced ability to communicate could diminish the use of such tactics during play. Given the diversity of 50 kHz calls (Wright et al, 2010(Wright et al, , 2012, a detailed analysis of the temporal structure of when different calls are emitted during the course of the momentto-moment maneuvers performed during play may shed light on such deficits in communication. These communicatory effects of VPA need not be exclusive from the effects on the motivation and reward systems for social contact.…”

Section: Resultsmentioning

confidence: 99%

Effects of prenatal exposure to valproic acid on the development of juvenile-typical social play in rats

Raza

Himmler

et al. 2015

Behavioural Pharmacology

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Autism is a severe neurodevelopmental disorder characterized by qualitative impairments in social behavior, communication, and aberrant repetitive behaviors. A major focus of animal models of autism has been to mimic the social deficits of the disorder. The present study assessed whether rats exposed prenatally to valproic acid (VPA) show deficits in social play as juveniles that are consistent with the social deficits observed in autism. Dams were exposed to an acute dose of VPA on gestational day 12.5. Later, the playful interactions and associated ultrasonic vocalizations of the juveniles were examined. It was predicted that VPA-treated rats should play less than the controls. Characteristic of neurobehavioral insult at this early age, the VPA-treated juveniles showed significant increases in the frequency of body shakes and sexual mounting, but played at the same frequency as the controls. However, when playing, they were less likely to use tactics that facilitated bodily contact and vocalized less. These data suggest that prenatal VPA exposure disrupts some aspects of being able to communicate effectively and engage partners in dynamic interactions - deficits that are consistent with those observed in autism.

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Section: Resultsmentioning

confidence: 99%

Effects of prenatal exposure to valproic acid on the development of juvenile-typical social play in rats

Raza

Himmler

et al. 2015

Behavioural Pharmacology

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“…Previous work has demonstrated a significant contribution of the noradrenergic system to acoustic variables; for example, call rate is increased with noradrenergic system treatments in adult rats [78]. However, the effect on acoustic parameters including intensity, bandwidth and peak frequency are currently unknown.…”

Section: Discussionmentioning

confidence: 99%

Vocal training, levodopa, and environment effects on ultrasonic vocalizations in a rat neurotoxin model of Parkinson disease

Kelm‐Nelson

Bräuer

Ciucci

2016

Behavioural Brain Research

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Levodopa does not improve dysarthria in patients with Parkinson Disease (PD), although vocal exercise therapy, such as “LSVT/LOUD®”, does improve vocal communication. Most patients receive vocal exercise therapy while concurrently being treated with levodopa, although the interaction between levodopa and vocal exercise therapy on communication in PD is relatively unknown. Further, carryover of vocal exercise therapy to novel situations is critical for successful outcomes, but the influence of novel situations on rehabilitated vocal communication is not well understood. To address the influence of exercise, medications, and environment on vocal communication with precise experimental control, we employed the widely used 6-OHDA rat neurotoxin model of PD (infusion to the medial forebrain bundle), and assessed ultrasonic vocalizations after: vocal exercise, vocal exercise with levodopa, levodopa alone, and control conditions. We tested USVs in the familiar training environment of the home cage and a novel cage. We hypothesized that parkinsonian rats that undergo vocal exercise would demonstrate significant improvement of ultrasonic vocalization (USV) acoustic parameters as compared to the control exercise and levodopa-only treatment groups. We further hypothesized that vocal exercise in combination with levodopa administration, similar to what is common in humans, would lead to improvement in USV outcomes, particularly when tested in a familiar versus a novel environment. We found that the combination of exercise and levodopa lead to some improvement in USV acoustic parameters and these effects were stronger in a familiar vs. a novel environment. Our results suggest that although treatment can improve aspects of communication, environment can influence the benefits of these effects.

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“…[51] Given this, it is possible that some aspects of the observed vocalization deficits are related to norepinephrine loss in addition to dopamine loss. It has been demonstrated that selectively agonizing or antagonizing noradrenergic receptors results in differential alterations to call rate in profile,[52] though the contribution of norepinephrine to other acoustic parameters such as intensity, bandwidth and peak frequency are unknown. In addition, preliminary work in our lab indicates that systemic injections of the noradrenergic neurotoxin DSP-4 results in acute, transient alterations to acoustic parameters of ultrasonic vocalizations such as intensity and bandwidth (unpublished).…”

Section: Discussionmentioning

confidence: 99%

Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion

Grant

Barnett

Doll

et al. 2015

Behavioural Brain Research

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Voice deficits in Parkinson disease (PD) emerge early in the disease process, but do not improve with standard treatments targeting dopamine. Experimental work in the rat shows that severe and chronic unilateral nigrostriatal dopamine depletion with 6-OHDA results in decreased intensity, bandwidth, and complexity of ultrasonic vocalizations. However, it is unclear if mild/acute dopamine depletion, paralleling earlier stages of PD, results in vocalization deficits, or to what degree vocalization parameters are correlated with other dopamine-dependent indicators of lesion severity or percent of tyrosine hydroxylase (%TH) loss. Here, we assayed ultrasonic vocalizations, forelimb asymmetry, and apomorphine rotations in rats with a range of unilateral dopamine loss resulting from 6-OHDA or vehicle control infusions to the medial forebrain bundle at acute (72 hours) and chronic (4 weeks) time points post-infusion. The %TH loss was evaluated at 4 weeks. At 72 hours, forelimb asymmetry and %TH loss were significantly correlated, while at 4 weeks, all measures of lesion severity were significantly correlated with each other. Call complexity was significantly correlated with all measures of lesion severity at 72 hours but only with %TH loss at 4 weeks. Bandwidth was correlated with forelimb asymmetry at both time points. Duration was significantly correlated with all dopamine depletion measures at 4 weeks. Notably, not all parameters were affected universally or equally across time. These results suggest that vocalization deficits may be a sensitive index of acute and catecholamine loss and further underscores the need to characterize the neural mechanisms underlying vocal deficits in PD.

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α- and β-Adrenergic Receptors Differentially Modulate the Emission of Spontaneous and Amphetamine-Induced 50-kHz Ultrasonic Vocalizations in Adult Rats

Cited by 71 publications

References 113 publications

Effects of prenatal exposure to valproic acid on the development of juvenile-typical social play in rats

Effects of prenatal exposure to valproic acid on the development of juvenile-typical social play in rats

Vocal training, levodopa, and environment effects on ultrasonic vocalizations in a rat neurotoxin model of Parkinson disease

Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion

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