α-Amylase Inhibitors from Roselle (Hibiscus sabdariffaLinn.) Tea

Abstract

A roselle (Hibiscus sabdariffa Linn.) tea extract was found to have high inhibitory activity against porcine pancreatic alpha-amylase. Hibiscus acid and its 6-methyl ester were respectively isolated as active principles from the 50% methanol and acetone extracts of roselle tea. The activity of each isolate was compared to that of structurally related citric acid, a previously known inhibitor of fungal alpha-amylase.

Methyl Caffeate as an α-Glucosidase Inhibitor fromSolanum torvumFruits and the Activity of Related Compounds

“…Hence, to investigate the effects of the ester moiety together with the caffeoyl moiety against -glucosidase inhibition, we synthesized or purchased a series of caffeoyl ester 2-8 and methyl caffeate analogs 9-14, and tested for sucrase and maltase inhibitory activities. The compounds tested included four linear alkyl caffeates (2-4), two branched-chain alkyl caffeates (5, 6), phenyl caffeate (7), a ketone analog (10), methyl dihydrocaffeate (11), and two trihydroxycinnamates (13,14), and chlorogenic acid (8), caffeic acid (9), and methyl protocatechuate (12) (Fig. 1).…”

“…2) In recent years, many efforts have been made to search for effective -glucosidase inhibitors from natural sources in order to develop a physiological functional food or to discover lead compounds for medicinal usage against diabetes. 3) In the course of our search for rat intestinal -glucosidaseinhibiting principles from various plants, we have isolated and identified several active compounds from plants grown in Asian regions, including Japan, [4][5][6][7] Thailand, 8,9) China, 10,11) and Nepal. 12) In this paper, we present the results of a screening of plants cultivated in Tanegashima, a southern island of Japan, for rat intestinal -glucosidase inhibition.…”

Nutritional and Health Importance of Hibiscus Sabdariffa: A Review and Indication for Research Needs

“…Intestinal α-glycosidase and pancreatic α-amylase help in digestion of complex carbohydrates present in the food into bioavailable monosaccharide and plays an important role in postprandial hyperglycaemia; therefore inhibition of these enzymes has been reported as an effective mechanism for the control of postprandial hyperglycaemia. Hibiscus acid (hibiscus-type (2S,3R)-hydroxycitric acid lactone) have been shown as a potent inhibitor of pancreatic α-amylase and intestinal α-glucosidase and pancreatic α-amylase activity [28,29]. In another study, Adisakwattana et al [30], conducted an in vitro study and reported Roselle extracts as an effective inhibitor of pancreatic α-amylase.…”

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

“…During the last 40 years, a large number of glucosidase inhibitors have been isolated from plants and micro-organisms 1 and some of these were developed as drugs to control type II or noninsulin dependent diabetes 2 . Different inhibitors isolated from plants and microorganisms include diverse types of compounds like acarbose, isoacarbose, cyclodextrins, acarviosine-glucose and hibiscus acid [3][4][5][6] . Although the list of α-glucosidase inhibitors isolated from various biological sources are long, yet the bioactive molecules of traditional antidiabetic herbal drugs characterized are few in number.…”