α-Amylase and α-glucosidase inhibitor effects and pancreatic response to diabetes mellitus on Wistar rats of Ephedra alata areal part decoction with immunohistochemical analyses

Glucosidase Inhibitors Screening in Microalgae and Cyanobacteria Isolated from the Amazon and Proteomic Analysis of Inhibitor Producing Synechococcus sp. GFB01

“…Glucosidases cleave sugars in the intestinal tract forming d -glucose, which is absorbed by the intestine, raising blood glycogen levels. The inhibitors therefore act in a competitive manner, preventing the action of these enzymes and avoiding postprandial hyperglycemia [ 7 , 8 , 9 ].…”

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“…Activity [13,14] The Reducing Power Assay [15] According to Oyaizu (1986), 250 reducing power was evaluated as follows, 2.5 ml volume of various concentrations of extracts (10-320 μg/ml) was mixed with sodium phosphate buffer (2.5 ml, 200 mM) and potassium ferricyanide (2.5 ml, 1%) at pH 6.6. After mixing, the solution was incubated (50°C for 20 min) and then trichloroacetic acid (2.5 ml of 10% w/v) was added into the above solution.…”

Ephedra alata extracts exhibits anti-obesity, anti-hyperlipidaemic, anti-hyperglycemia, anti-antipyretic and analgesic effects through the inhibition of lipase, α-amylase and inflammation

“…Ephedra alata was an important source of several pharmaceutical compounds such of cardiac glycosides, reducing sugars, avonoids, phenolic compounds, and alkaloids; and as Signi cant medicinal properties of this genus were reported such as antimicrobial, antioxidant, antidiabetic, hepatoprotective, cardiovascular, and anticancer effects [13][14][15][16]. Previous studies have reported that Ephedra Herb may have applications in cancer therapy and suppressed cancer metastasis by inhibiting cancer cell motility [17,8,9] and prevented hepatocyte growth factor (HGF)-induced cancer cell motility by inhibiting phosphorylation of the c-Met receptor [17].…”