α-Amino acids: Natural and artificial building blocks for discrete polymetallic clusters

Canaj, Angelos B.; Kakaroni, Foteini E.; Collet, Alexandra; Milios, Constantinos J.

doi:10.1016/j.poly.2018.05.005

Cited by 12 publications

(7 citation statements)

References 252 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1). Recent reviews describe the structural diversity afforded by coordination compounds using this family of molecules as ligands and summarize some of their properties and uses (Canaj et al, 2018;Arunadevi & Raman, 2020). For example, their photochromic (Nakagame et al, 2019) and optical nonlinearity properties (Almashal et al, 2020), and biological and pharmacological activities (Berthon, 1995;Burger, 1990) have been explored.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural and electrochemical properties of a new family of amino-acid-based coordination complexes

Rey¹,

Movilla²,

Suárez³

et al. 2022

Acta Crystallogr Sect B

View full text Add to dashboard Cite

Metalloproteins involved in oxidation–reduction processes in metabolism are fundamental for the wellbeing of every organism. The use of amino-acid-based compounds as ligands for the construction of biomimetic coordination systems represents a promising alternative for the development of new catalysts. Herein is presented a new family of copper, zinc and nickel coordination compounds, which show four-, five- and six- coordination geometries, synthesized using Schiff base ligands obtained from the amino acids L-alanine and L-phenylalanine. Structural analysis and property studies were performed using single-crystal X-ray diffraction data, spectroscopic and electrochemical experiments and DFT calculations. The analysis of the molecular and supramolecular architectures showed that the non-covalent interactions developed in the systems, together with the identity of the metal and the amino acid backbone, are determinants for the formation of the complexes and the stabilization of the resultant geometries. The CuII complexes were tested as candidates for the electrochemical conversion reduction of nitrite to NO, finding that the five-coordinate L-phenylalanine complex is the most suitable. Finally, some insights into the rational design of ligands for the construction of biomimetic complexes are suggested.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, structural and electrochemical properties of a new family of amino-acid-based coordination complexes

Rey¹,

Movilla²,

Suárez³

et al. 2022

Acta Crystallogr Sect B

View full text Add to dashboard Cite

show abstract

“…It is required for crossing the bloodbrain barrier, where it converts to tyrosine and produces important hormones like norepinephrine and epinephrine (Ufuk et al, 2020). Because of their diversity in terms of coordination mode and binding capabilities towards metals, amino acids are particularly important family of organic ligands that have been explored for the production of metallic complexes ions (Canaj et al, 2018). Amino acids bind to transition metal ions via the carboxylate oxygen and the amine nitrogen donor atoms, forming a thermodynamically stable chelate ring under biological conditions (Alvarez, 2020;Ufuk et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antioxidant Activity of Mixed–Ligand Complexes of Mn(Ii), Co(Ii), Ni(Ii), Cu(Ii) And Zn(Ii) Ions with Nicotinic Acid and Phenylalanine

Goni¹,

Ndahi²,

Yesufu³

et al. 2022

AJBAR

View full text Add to dashboard Cite

Mixed ligand metal complexes of nicotinic acid and phenylalanine with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized and characterized using infrared spectroscopy, electronic spectra, conductivity, melting point, and solubility. Nicotinic acid and phenylalanine were reacted with some metal (II) chloride salts in the molar ratio of 1:2:1 (M: NA: Phe) which produced the complexes with various colours and a percentage yield range of 58 97%. The melting points of the compounds ranged from 320 to 348 oC, with conductivities ranging from 9.01-26.4 Scm-2mol-1. The infrared spectra of the ligands and metal complexes revealed that nicotinic acid is a monodentate ligand that coordinates to the metal via the nitrogen of the pyridine ring, whereas phenylalanine is a bidentate ligand that coordinates to the metal via the carbonyl oxygen v(C=O) and nitrogen of the amine v(N-H) groups. The electronic spectra of the compounds are compatible with an octahedral geometry, except for the zinc complex, which probably has a tetrahedral structure. All the complexes were slightly soluble in some of the organic solvents used, methanol, ethanol, dimethylformide (DMF), acetone, chloroform, ethyl acetate, and benzene. The ligands and complexes were evaluated for antioxidant activity in vitro using the DPPH and hydrogen peroxide methods. According to the findings, all the complexes have higher activity than the ligand (nicotinic acid) but were less active than the standard (ascorbic acid). This indicates, the complexes have strong antioxidant properties.

show abstract

“…Among the numerous organic ligands that have been employed for the formation of metallic complexes, amino acids consist a very important family of ligands, due to their versatility regarding the coordination mode and binding properties towards metal ions [10]. Amino acids are present in all living organisms, which are essential for various biochemical processes that ensure the permanence of life in the individuals, can act as potential oxygen and nitrogen donor ligands, too [11,12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural elucidation and electrochemical behavior of some oxime-phenylalanine mixed ligand complexes

Öztoprak¹,

Özkorucuklu²,

Baştemur³

et al. 2021

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

Four new mixed ligand complexes Me(II)/phenylalanine (phe)/HL [HL =4-(4-bromophenyl- aminoisonitrosoacetyl)biphenyl and Me = Co, Ni, Cu, Zn] were synthesized. These complexes are formulated as: [CoL(phe)(H2O)2], [NiL(phe)(H2O)2], [CuL(phe)(H2O)2] and [ZnL(phe)(H2O)2]. All the compounds were characterized by elemental analyses, FT-IR, magnetic susceptibility measurements, TG/DTA and cyclic voltammetry (CV) experiments. IR spectral data confirmed the coordination of the oxime ligand to the metal ions through the oxime and carbonyl oxygen. The geometrical structures of the complexes have been found to be octahedral. The measured molar conductance values of the complexes in DMF are in agreement with the non-electrolytic nature ofthe complexes. The elemental analyses confirm a 1:1:1 [metal:HL:L(phenylalanine)] molar ratio. Thermal behavior of the compound was investigated by thermal gravimetric analysis (TG) and differential thermal analysis (DTA) techniques. All the complexes were transformed into metal oxides after thermal degradation. The electrochemical properties of both ligand and their complexes were analyzed by cyclic voltammetry (CV) using glassy carbon electrode in DMF solution containing 0.1 M TBAP as supporting electrolyte. KEY WORDS: Oxime, electrochemical characterization, mixed ligand complexes, amino acid, phenylalanine Bull. Chem. Soc. Ethiop. 2020, 34(3), 543-556. DOI: https://dx.doi.org/10.4314/bcse.v34i3.10

show abstract

α-Amino acids: Natural and artificial building blocks for discrete polymetallic clusters

Cited by 12 publications

References 252 publications

Synthesis, structural and electrochemical properties of a new family of amino-acid-based coordination complexes

Synthesis, structural and electrochemical properties of a new family of amino-acid-based coordination complexes

Synthesis, Characterization and Antioxidant Activity of Mixed–Ligand Complexes of Mn(Ii), Co(Ii), Ni(Ii), Cu(Ii) And Zn(Ii) Ions with Nicotinic Acid and Phenylalanine

Synthesis, structural elucidation and electrochemical behavior of some oxime-phenylalanine mixed ligand complexes

Contact Info

Product

Resources

About