α-Adrenoceptor blockers and phaeochromocytoma surgery: outdated combination?

Gunnesson, Lisa; Nilsson, Maria; Larsson, Peter; Ragnarsson, Oskar; Muth, Andreas

doi:10.1093/bjs/znac201

Cited by 1 publication

(1 citation statement)

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“…The outcome was favorable for the entire cohort and did not differ based on use of alpha blockers. Recent studies have suggested pre-operative alpha blockers in non-pregnant Pc patients to be of less importance than previously implied, largely thanks to modern surgical and anesthesiologic techniques [ 27 , 28 ]. In parallel, contemporary maternal and perinatal care in developed countries is generally safe, and perhaps the recommendation of referral of such patients to specialist centers and careful monitoring is likely more important than the alpha blocker per se [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal pheochromocytoma and childbirth in Sweden 1973–2015: a population-based study on short and long-term outcome

Gunnesson,

Ragnarsson,

Nilsson

et al. 2024

Endocrine

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Purpose Data guiding management of pheochromocytoma and paraganglioma (PPGL) in pregnant women is limited, and long-term effects on the child are unknown. The aim of this retrospective registry-based case-cohort study was to assess how maternal PPGL and treatment impacts maternal and fetal outcome, including long-term outcome for the child. The main outcomes were maternal and fetal mortality and morbidity at delivery and relative healthcare consumption in children born by mothers with PPGL during pregnancy. Methods The National Birth Register identified 4,390,869 pregnancies between 1973–2015. Data was crosslinked with three Swedish national registers to identify women diagnosed with pheochromocytoma or paraganglioma within one year before or after childbirth. Hospital records were reviewed and register data was collected for five age-matched controls for each child until age 18. Results 21 women and 23 children were identified (incidence 4.8/1.000.000 births/year), all women with adrenal pheochromocytomas (Pc). The majority (71%) were diagnosed post-partum. Nine women (43%) were hypertensive during pregnancy. Preterm delivery was more common in Pc patients compared to controls (30% vs 6%, p < 0.001). There was no maternal or fetal mortality. Timing of tumor removal did not affect gestational weight or APGAR scores. There was no observed difference in hospital admissions between children affected by maternal Pc and controls. Conclusion Pc was commonly diagnosed after delivery and raised the risk of pre-term delivery, suggesting a need for an increased awareness of this diagnosis. However, reassuringly, there was no fetal or maternal mortality or any observed long-term impact on the children.

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Section: Discussionmentioning

confidence: 99%