α-1 Microglobulin as a New Inflammatory Marker in Newly Diagnosed Hypertensive Patients

Vyssoulis, Gregory P.; Tousoulis, Dimitris; Antoniades, Charalambos; Dimitrakopoulos, S.; Zervoudaki, A.; Stefanadis, Christodoulos

doi:10.1016/j.amjhyper.2007.01.010

Cited by 24 publications

(20 citation statements)

References 22 publications

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“…A1m is known to be complexed to macromolecules (immunoglobulin A, albumin, and prothrombin), as well as to be present in a free form of a monomeric protein [18]. This protein is considered to be a marker of renal insufficiency, and to reflect the overall inflammatory status in patients with arterial hypertension and normal renal function [19]. We found that spot 18 (protein AMBP) differed significantly when mutually comparing all four groups.…”

Section: Discussionmentioning

confidence: 99%

Plasma proteome changes in cardiovascular disease patients: novel isoforms of apolipoprotein A1

et al. 2011

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BackgroundThe aim of this proteomic study was to look for changes taking place in plasma proteomes of patients with acute myocardial infarction (AMI), unstable angina pectoris (UAP), and stable angina pectoris (SAP).MethodsDepleted plasma proteins were separated by 2D SDS-PAGE (pI 4-7), and proteomes were compared using Progenesis SameSpots statistical software. Proteins were identified by nanoLC-MS/MS. Proteins were quantified using commercial kits. Apolipoprotein A1 was studied using 1D and 2D SDS-PAGE, together with western blotting.ResultsReciprocal comparison revealed 46 unique, significantly different spots; proteins in 34 spots were successfully identified and corresponded to 38 different proteins. Discrete comparisons of patient groups showed 45, 41, and 8 significantly different spots when AMI, UAP, and SAP were compared with the control group. On the basis of our proteomic data, plasma levels of two of them, alpha-1 microglobulin and vitamin D-binding protein, were determined. The data, however, failed to prove the proteins to be suitable markers or risk factors in the studied groups. The plasma level and isoform representation of apolipoprotein A1 were also estimated. Using 1D and 2D SDS-PAGE, together with western blotting, we observed extra high-molecular weight apolipoprotein A1 fractions presented only in the patient groups, indicating that the novel high-molecular weight isoforms of apolipoprotein A1 may be potential new markers or possible risk factors of cardiovascular disease.ConclusionThe reported data show plasma proteome changes in patients with AMI, UAP, and SAP. We propose some apolipoprotein A1 fractions as a possible new disease-associated marker of cardiovascular disorders.

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Section: Discussionmentioning

confidence: 99%

Plasma proteome changes in cardiovascular disease patients: novel isoforms of apolipoprotein A1

et al. 2011

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“…There is controversial evidence from a rat model that the synthesis of α 1 -microglobulin may be stimulated by IL-6 [31]. Recently, Vyssoulis et al [32 ]have found that urinary α 1 -microglobulin is independently associated with circulating acute-phase proteins in patients with newly diagnosed hypertension.…”

Section: Discussionmentioning

confidence: 99%

The Severity of Acute Puumala Hantavirus Infection Does Not Predict the Long-Term Outcome of Patients

Miettinen

Mäkelä²,

Ala‐Houhala³

et al. 2010

Nephron Clin Pract

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Background/Aims: We have found greater urinary protein excretion and higher glomerular filtration rate (GFR) and blood pressure in patients 6 years after acute nephropathia epidemica (NE) compared with seronegative controls. The present aim was to establish whether the long-term outcome is determined by the severity of acute illness. Methods: Serial plasma interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), creatinine, C-reactive protein, blood cell count as well as 24-hour urinary protein and overnight α₁-microglobulin and albumin excretions were measured in 37 patients with acute NE. Human leucocyte antigen (HLA)-B, HLA-DRB1, TNF-α(–308) and IL-6(–174) alleles were also analyzed. After 6 years, GFR, blood pressure and urinary protein excretion were examined. Results: There were no associations between the clinical severity of acute NE or the genetic factors determined and the increased GFR, hypertension or 24-hour urinary protein excretion observed 6 years later. The degree of inflammation during the acute phase was higher in patients who had increased urinary excretion of α₁-microglobulin 6 years later compared with those with no α₁-microglobulin excretion. Conclusion: Neither the severity of acute NE nor the host genetic factors determined the predicted renal function, blood pressure or 24-hour urinary protein excretion 6 years later.

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“…They concluded that urinary A1M may reflect the overall inflammatory status in patients with newly diagnosed hypertension, beyond its value as a marker of renal function [14]. In order to exclude the variation associated with inflammatory markers we evaluated CRP and ferritin.…”

Section: Discussionmentioning

confidence: 99%

Urinary Biomarkers for Kidney Disease in ATTR Amyloidosis

F¹

2014

J Nephrol Ther

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α-1 Microglobulin as a New Inflammatory Marker in Newly Diagnosed Hypertensive Patients

Cited by 24 publications

References 22 publications

Plasma proteome changes in cardiovascular disease patients: novel isoforms of apolipoprotein A1

Plasma proteome changes in cardiovascular disease patients: novel isoforms of apolipoprotein A1

The Severity of Acute Puumala Hantavirus Infection Does Not Predict the Long-Term Outcome of Patients

Urinary Biomarkers for Kidney Disease in ATTR Amyloidosis

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