Zytostatische Induktionstherapie mit Cis-Platinum bei Kopf-Halstumoren

Böheim, K.; Böheim, C.; Rauchegger, H

doi:10.1007/bf00464272

Cited by 4 publications

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References 5 publications

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“…Investigating responses to chemotherapy of untreated patients with advanced HNSCC, Boheim et al reported that exophytic neoplasms responded better than those with the endophytic growth pattern [12]. It also has been reported that the exophytic tumors are more sensitive to radiotherapy (RT) compared to endophytic tumors [13, 14].…”

Section: Introductionmentioning

confidence: 99%

Head and neck squamous carcinomas with exophytic and endophytic type of growth have the same prognosis after surgery and adjuvant radiotherapy

Harasymczuk

Gooding

Kruk-Zagajewska

et al. 2012

Eur Arch Otorhinolaryngol

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Background Head and neck squamous cell carcinomas (HNSCC) are characterized by exophytic or endophytic growth. We hypothesized that the growth pattern predicts outcome and associates with distinct clinical and immunological profiles. Patients and Methods Tumors obtained from 60 HNSCC patients treated with surgery and adjuvant radiotherapy were identified as exophytic or endophytic. Recurrence free survival (RFS) at 42 months was determined. In a subsets of 30 patients (22 exophytic and 8 endophytic) tumor stroma and parenchyma were evaluated for infiltrating CD4+ and CD8+ T, dendritic, myeloid and FOXP3+ regulatory T cells (Treg) and expression of immunosuppressive cytokines by immunohistochemistry. The localization and frequency of positive cells were determined microscopically and analyzed by hierarchical clustering to distinguish exophytic vs. endophytic tumors. Results 34/60 patients had exophytic and 26/60 endophytic tumors. No differences in clinicopathologic data, disease progression or RFS were seen between the two cohorts. Infiltrates of CD3+CD8+ T cells were larger in endophytic than exophytic tumors, while FOXP3+ Treg; TGF-β+, IL-10+, Arg-1+, CD11b+ cells were equally prominent in both. FOXP3+ Treg accumulated in endophytic tumor nests, while exophytic tumor stroma was enriched in IL-10+ cells (both at p<0.05). Hierarchical clustering based on immunophenotyping failed to identify different clusters in these two tumor types. However, CD68+ macrophages and FOXP3+ Treg showed a distinct distribution. Conclusions The HNSCC growth pattern did not predict RFS. Although higher numbers and differences in localization of immunosuppressive cells in endophytic vs. exophytic tumors were observed, no significant relationship was established between the growth pattern and the immune profile of infiltrating lymphocytes.

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Section: Introductionmentioning

confidence: 99%

Head and neck squamous carcinomas with exophytic and endophytic type of growth have the same prognosis after surgery and adjuvant radiotherapy

Harasymczuk

Gooding

Kruk-Zagajewska

et al. 2012

Eur Arch Otorhinolaryngol

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The effect of chemotherapy in relation to pathohistological tumour grading in head and neck cancer

Böheim

Spoendlin

1983

Arch Otorhinolaryngol

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Histological serial sections of resection specimens from 37 patients suffering from advanced squamous cell carcinoma (SCC) of the oral cavity, oropharynx, hypopharynx, and supraglottic region of the larynx were examined after pre-operative chemotherapy with methotrexate (M), bleomycin (B), and cisplatin (P) - (MBP). Pathohistological grading criteria for SCC from various sources were used. Results were compared with initial biopsy specimens. Statistical interpretation was carried out with the sign test. Mode of growth, degree of keratinization, mode of invasion and cellular reaction showed a significant change towards more benign behaviour. However, the maturity of the remaining tumour cells showed a considerable tendency towards greater malignancy. Some grading criteria proved to be insufficient for the determination of statistically significant alterations, with the exception of keratinization, which showed a change towards benignity. Results obtained for the different mechanisms of action of drugs used in the MBP-combination and the different regression behaviour of variously differentiated squamous cell carcinomas under chemotherapy are discussed in this study.

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The prognostic influence of induction chemotherapy on advanced head and neck carcinoma

Picker

Zingerle

Böheim

et al. 1986

Arch Otorhinolaryngol

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We examined the influence of induction chemotherapy integrated with surgery and postoperative radiotherapy on 5-year treatment results of 107 patients suffering from advanced head and neck carcinomas. The chemotherapy regimen consisted of one to three cycles of a combination of cisplatin, methotrexate and bleomycin. The overall response rate to induction chemotherapy was 58% with a 26% complete response rate. Using actuarial life tables, survival was 44% for all patients. The initial tumor stages were found to be predictive for patients' responses to chemotherapy as well as for their survivals. The overall response rate was 65% for T-3 tumors vs 29% for T-4 tumors. Five-year survival was 54% for T-3 vs 24% for T-4 tumors. The other predictive factor for survival was response to chemotherapy. Five-year survival was 73% for those patients achieving a complete response vs 17%-37% for patients with any residual disease after drug treatment. Since a favorable response to chemotherapy was strongly associated with a lesser T-stage as well as with significantly better survival of patients in our study, we conclude that induction chemotherapy may best benefit those patients with smaller tumors. Our findings show that a complete response to chemotherapy can also serve as a good prognostic sign, although an a priori better prognosis is still associated with patients who have smaller tumors.

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Zytostatische Induktionstherapie mit Cis-Platinum bei Kopf-Halstumoren

Cited by 4 publications

References 5 publications

Head and neck squamous carcinomas with exophytic and endophytic type of growth have the same prognosis after surgery and adjuvant radiotherapy

Head and neck squamous carcinomas with exophytic and endophytic type of growth have the same prognosis after surgery and adjuvant radiotherapy

The effect of chemotherapy in relation to pathohistological tumour grading in head and neck cancer

The prognostic influence of induction chemotherapy on advanced head and neck carcinoma

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