Zygotic spindle orientation defines cleavage pattern and nuclear status of human embryos
Volodymyr Porokh,
Drahomíra Kyjovská,
Martina Martonová
et al.
Abstract:The first embryonic division represents a starting point for the development of a new individual. In many species, tight control over the first embryonic division ensures its accuracy. However, the first division in humans is often erroneous and can impair embryo development. To delineate the spatiotemporal organization of the first mitotic division typical for normal human embryo development, we systematically analyzed a unique timelapse dataset of 300 IVF embryos that developed into healthy newborns. The zyg… Show more
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