Zygophyllum gaetulum attenuates hypercholesterolemia and protects against oxidative stress in rats fed a high-cholesterol diet

Berzou, Sadia; Taleb-Senouci, D.; Guenzet, Akila; Krouf, Djamil

doi:10.5455/jeim.111014.or.113

Cited by 2 publications

(3 citation statements)

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“…Lipid peroxidation is one of the processes by which free radicals can damage cells, affecting cell membranes and triggering a cascade of reactions that can impair cellular function. An in vivo investigation was conducted on rats with hypercholesterolemia, administering lyophilized aqueous extract at a level of 1g/100 g (16). The aqueous extract of Z.gaetulum reduced TBARS (an indicator of lipid peroxidation) levels in the liver, plasma, heart, aorta, and brain compared to untreated rats.…”

Section: Antioxidant Activitymentioning

confidence: 99%

An overview on pharmacological, ethnomedicinal, and phytochemical investigations of Zygophyllum gaetulum Emb. & Maire - an endemic species of southeast of Morocco

Janah,

Elhasnaoui,

Ben Bammou

et al. 2024

Plant Sci. Today

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Zygophyllum gaetulum Emb. Maire (Zygophyllaceae), commonly known as "El Aggaya" or "El Berraya", is a medicinal plant Indigenous to the Moroccan Sahara. It exhibits endemic characteristics and is notably prevalent in the Drâa-Tafilalet region. Within Moroccan folk medicine, this plant holds a reputation for its efficacy in treating various ailments. It is recognized for its traditional applications in alleviating stomach pain, and addressing eczema and dermatitis, and stands out as one of the frequently employed plants for managing diabetes. The purpose of this review paper was to highlight the importance of Zygophyllum gaetulum (Z. gaetulum) by summarizing the literature investigations reported on various ethnopharmacological and phytochemical aspects as well as biological properties to stimulate interest in promoting its domestication and commercialization for global markets. The data and information on Z. gaetulum were collated from various resources like ethnobotanical textbooks and literature databases such as Springer, Scopus, PubMed, Science Direct, Wiley, Tailor and Francis, and Google Scholar. The phytochemical screening of the different parts of Z. gaetulum indicates that the leaves are rich in saponins (bisdesmosidic triterpene saponins), terpenes, and sterols. 33 compounds were identified from fruits, leaves, and stem roots. They are generally composed of terpenoids, such as caryophyllene E, decanone, and bornylacetate. In addition, Z. gaetulum demonstrated several biological properties such as antioxidant, antidiabetic, and anti-inflammatory effects. These activities allow the application of Z. gaetulum in the medicinal field. Hence, it is crucial to conduct thorough investigations into the phytochemical composition of the plant and to assess its pharmacological activity. This approach is essential for future drug discovery and development endeavors.

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Section: Antioxidant Activitymentioning

confidence: 99%

An overview on pharmacological, ethnomedicinal, and phytochemical investigations of Zygophyllum gaetulum Emb. & Maire - an endemic species of southeast of Morocco

Janah,

Elhasnaoui,

Ben Bammou

et al. 2024

Plant Sci. Today

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“…Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide in most developing countries (Berzou et al, 2014).…”

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confidence: 99%

“…

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide in most developing countries (Berzou et al, 2014).World Health Organization (2017) estimated that about 2.6 million deaths and 29.7 million disability-adjusted life years among the global population due to diseases related to cholesterol elevation in blood.

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confidence: 99%

Functional food mixtures: Inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats

Rosmi

Shafie

Azlan

et al. 2020

Food Science & Nutrition

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Mixtures of selected functional foods (MSFF) were composed of nattokinase (fermented soybean), red yeast rice extract, Ginkgo biloba, oat fiber, garlic, bee pollen, and propolis as anti‐hypercholesterolemic were studied. The goal of this study was to determine the bioactive compounds in these mixtures and their cholesterol‐lowering potential effects (biochemical profiles, lipid peroxidation, liver tissue histopathology, and enzymatic activity analysis; HMGCoA reductase and ACAT2. The LC‐MS/MS analysis showed that bioactive compounds such as Monacolin K, naringin, tocopherol, and glutamate, which have potential as anti‐hypercholesterolemic agents, were present in these functional food mixtures. MSFF supplementation at 50 mg/kg 100 mg/kg and 200 mg/kg showed substantial reductions in serum lipid profiles (TC and LDL) (p < .05). The serum liver profiles of AST (115.33 ± 8.69 U/L) and ALT (61.00 ± 1.00 U/L) were significantly reduced (p < .05) with MSFF supplementation at 200 mg/kg. MDA lipid peroxidation has also decreased significantly (p < .05) in serum (3.69 ± 0.42 μmol/L) and liver (15.04 ± 0.97 μmol/mg) tissues and has been shown to protect against hepatic steatosis. The significant (p < .05) inhibition activity of HMGCoA reductase (163.82 ± 3.50 pg/ml) and ACAT2 (348.35 ± 18.85 pg/ml) was also attributed by the supplementation of MSFF at 200 mg/kg.

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Zygophyllum gaetulum attenuates hypercholesterolemia and protects against oxidative stress in rats fed a high-cholesterol diet

Cited by 2 publications

References 0 publications

An overview on pharmacological, ethnomedicinal, and phytochemical investigations of Zygophyllum gaetulum Emb. & Maire - an endemic species of southeast of Morocco

An overview on pharmacological, ethnomedicinal, and phytochemical investigations of Zygophyllum gaetulum Emb. & Maire - an endemic species of southeast of Morocco

Functional food mixtures: Inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats

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