Zygophyllum album saponins prevent atherogenic effect induced by deltamethrin via attenuating arterial accumulation of native and oxidized LDL in rats

Feriani, Anouar; Tir, Meriam; Hachani, Rafik; Gómez-Caravaca, Ana María; Contreras, María del Mar; Taamalli, Amani; Talhaoui, Nassima; Segura‐Carretero, Antonio; Ghazouani, Lakhdar; Mufti, Afoua; Tlili, Nizar; Feki, Abdelfattah El; Harrath, Abdel Halim; Allagui, Mohamed Salah

doi:10.1016/j.ecoenv.2020.110318

Cited by 15 publications

(7 citation statements)

References 58 publications

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“…Dysregulation of the JAK-STAT pathway is linked to a number of neurodegenerative diseases, cancer, ischemia, epilepsy, angiogenesis, and inflammation of the brain [66]. DM increased the pro-inflammatory cytokine levels IL-2, IL-6, and TNF-α in rats [67]. Upon exposure to injury, microglia, immune, and glial cells release cytokines such as IL-13, IL-1, IL-6, and TNF-α [68].…”

Section: Discussionmentioning

confidence: 99%

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Khalifa

Moselhy

Mohammed

et al. 2022

Toxics

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Deltamethrin (DM) is the most powerful synthetic pyrethroid that has toxicity to the central nervous system and results in behavioral changes in both animals and humans. This effect is mediated by inducing alterations in the action of neurotransmitters and brain pathological changes. Nanocarrier encapsulated pesticides may decrease the toxicity of pesticides. Thus, this study aimed to determine the effect of an inorganic metal carrier (silica Nps) and polymeric capsule (chitosan Nps) of deltamethrin nano-formulations on antioxidant levels and oxidative stress in the brain and on behavior of the male albino rat. Sixty male albino rats were equally divided into four groups. Group I: control group; group II given DM liquefied in corn oil at 3.855 mg/kg BW; group III receiving silica-loaded deltamethrin (S/DM Nps) at 8.795 mg/kg BW; and group IV: given chitosan encapsulated deltamethrin (CS/DM Nps) at 30.44 mg/kg BW. All treatments were given orally for four weeks. Following this, behavioral tests were conducted to record locomotor activity, anxiety like behaviors, exploration, and the short memory of rats. In addition, brain antioxidant/oxidant, serum neurotransmitters such as acetylcholine esterase (AchE) and monoamine oxidase (MAO), JAK2 and STAT3 gene and proteins expression were measured. The DM group showed a highly significant elevation in malondialdehyde content, MAO, AchE, vascular endothelial growth factor (VEGF) levels, and the expression level of neurogenic genes, JAK2 and STAT3, in comparison with the control group. Both S/DM Nps and CS/DM Nps significantly decreased MAO, AchE, and VEGF compared with the DM group. Moreover, both S/DM Nps and CS/DM Nps significantly decreased the gene and proteins expression of JAK2 and STAT3 compared with the DM group. These alterations were evidenced by the deficiency in memory and learning behaviors that were accompanied by histopathological findings of the hippocampus and the cortex. It was concluded that the nano formulations containing DM induced less neurobehavioral toxicity than free DM. Additionally, the use of nanocarriers reduced the damage to health and the environment.

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Section: Discussionmentioning

confidence: 99%

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Khalifa

Moselhy

Mohammed

et al. 2022

Toxics

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“…[36] Alterations in plasma profile and lipid homeostasis were evident in rats exposed to tetramethrin and prallethrin via the nasal route. [37] Retention of native and oxidized LDL in the aorta, altered levels of cholesterol and HDL due to permethrin or bifenthrin induced toxicity in rats, [38,39] disturbances in the plasma biomarkers (inflammatory cytokines and that of liver function) by deltamethrin, [40] increased levels of plasma cholesterol and triglycerides in rats exposed to cypermethrin [41] and DNA damage in the peripheral lymphocytes of farmers who sprayed pesticides (deltamethrin) [42] are some recent reports related to the effects of pyrethroids on the hematological parameters. In this study, we observed disturbances in the levels of serum biomarkers that define liver function and lipid reported in apparently healthy subjects in Japan.…”

Section: Discussionmentioning

confidence: 99%

“…Hepato-renal damage associated with genotoxicity in rats was reported due to subacute exposure to the new pyrethroid, imiprothrin. [55] Alterations in the liver function enzymes by deltamethrin, [39,[55][56][57] hepatotoxicity of lambdacyhalothrin, [58] liver and kidney damage by bifenthrin, [59] altered biochemical parameters in liver by cypermethrin, [60] were reported. Furthermore, our previous studies presented the alterations in the biochemical associated with liver function by a mixture of pyrethroids.…”

Section: Discussionmentioning

confidence: 99%

Effect of a mixture of pyrethroids at doses similar to human exposure through food in the Indian context

Ravula

Yenugu

2022

J Biochem & Molecular Tox

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Residual amounts of pyrethroids were detected in rice and vegetables of the Indian market. Thus, consumers are exposed to a mixture of pyrethroids on a daily basis through food. Though a large number of studies reported the toxic effects of pyrethroids, there are no reports that used doses equivalent to human consumption. In this study, male Wistar rats were exposed daily to a mixture of pyrethroids for 1-15 months which is equivalent to the amount present in rice and vegetables consumed by an average Indian each day. The oxidant-antioxidant status (lipid peroxidation, nitric oxide; activities of catalase, glutathione peroxidase, glutathione S transferase, and superoxide dismutase) and anatomical changes in the general organs (liver, lung, and kidney) and male reproductive tract tissues (caput, cauda, testis, and prostate) were evaluated. Further, liver and kidney function tests, lipid profile, and complete blood picture were analyzed.Increased oxidative stress, perturbations in the antioxidant enzyme activities, and damage to the anatomical architecture were observed. Disturbances in the liver function and lipid profile were significant. Results of our study demonstrate that exposure to a mixture of pyrethroids at a dose that is equivalent to human consumption can cause systemic and reproductive toxicity, which may ultimately result in the development of lifestyle diseases. This first line of evidence will fuel further studies to determine the impact of food-based pyrethroid exposure on the long-term health of humans and to envisage policies to reduce pesticide content in food products.

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“…Lipid analysis by ORO. Fragments of fresh hepatic tissue were immediately cut (5 μm) using a cryostat, and stained by Oil red-O staining for the determination of lipid deposition, as reported by Feriani et al, 28 using a commercial histological kit (Histoserv, Inc., Gaithersburg, MD, USA). The sections were analysed and photographed using a light microscope.…”

Section: Food and Function Papermentioning

confidence: 99%

Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods

et al. 2022

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Zygophyllum album saponins prevent atherogenic effect induced by deltamethrin via attenuating arterial accumulation of native and oxidized LDL in rats

Cited by 15 publications

References 58 publications

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Effect of a mixture of pyrethroids at doses similar to human exposure through food in the Indian context

Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods

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