Zygomycosis of the Maxillary Sinus and Palate Caused by

Dworzack, David L.

doi:10.1001/archinte.1978.03630330074022

Cited by 49 publications

(7 citation statements)

References 9 publications

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“…Gatti et al (39) reported the first case from Africa and gave a detailed history of the reported cases involving entomophthoralean fungi until 1968. Since then, numerous cases have been reported from tropical and subtropical areas of the world, including the United States (31)(32)(33)(34)(35)(40)(41)(42). Although earlier controversies on the taxonomic Basidiobolus species affecting humans suggested the presence of two other species, B. haptosporus (8) and B. meristosporus (9), it was later found that B. ranarum was the only species affecting humans and lower animals such as horses, dogs, and others (14,26).…”

Section: Human-infecting Entomophthorales: Historical Perspectivesmentioning

confidence: 99%

“…Spread of the invading hyphae to lymph nodes, liver, and pancreas has also been reported (170,203,204). Unusual cases of systemic infection involving lungs, maxillary sinus and palate, and muscle have also been described (41,133,191). Differential diagnoses comprises colon carcinoma, inflammatory bowel disease, intestinal pythiosis, intestinal parasitic infections, intestinal mucormycosis, and others (31,32,183,199,204).…”

Section: Basidiobolomycosis: Basidiobolus Ranarummentioning

confidence: 99%

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Human Pathogenic Entomophthorales

Vilela

Mendoza

2018

Clin Microbiol Rev

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SUMMARYThe pathogenic entomophthoralean fungi cause infection in insects and mammalian hosts. and species can be found in soil and insect, reptile, and amphibian droppings in tropical and subtropical areas. The life cycles of these fungi occur in these environments where infecting sticky conidia are developed. The infection is acquired by insect bite or contact with contaminated environments through open skin. typically causes chronic rhinofacial disease in immunocompetent hosts, whereas some species can be found in immunocompromised patients. infection is restricted to subcutaneous tissues but may be involved in intestinal and disseminated infections. Its early diagnosis remains challenging due to clinical similarities to other intestinal diseases. Infected tissues characteristically display eosinophilic granulomas with the Splendore-Höeppli phenomenon. However, in immunocompromised patients, the above-mentioned inflammatory reaction is absent. Laboratory diagnosis includes wet mount, culture serological assays, and molecular methodologies. The management of entomophthoralean fungi relies on traditional antifungal therapies, such as potassium iodide (KI), amphotericin B, itraconazole, and ketoconazole, and surgery. These species are intrinsically resistant to some antifungals, prompting physicians to experiment with combinations of therapies. Research is needed to investigate the immunology of entomophthoralean fungi in infected hosts. The absence of an animal model and lack of funding severely limit research on these fungi.

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Section: Human-infecting Entomophthorales: Historical Perspectivesmentioning

confidence: 99%

Section: Basidiobolomycosis: Basidiobolus Ranarummentioning

confidence: 99%

Human Pathogenic Entomophthorales

Vilela

Mendoza

2018

Clin Microbiol Rev

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“…Basidiobolus is an insect pathogen that infects the entire insect body before being eaten by amphibians and reptiles. These fungi have the ability to infect humans through open skin, inhalation, or ingestion [ 7 ]. Basidiobolus can also cause chronic cutaneous and subcutaneous infections in the limbs, trunk, buttock, thigh, and perineum [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…We searched the existing English literature for all reported cases of basidiobolomycosis in children between 2005 and 2023, using the Medline database via PubMed, Embase via Scopus, ISI Web of Science, Science Direct, and Google Scholar. Despite the fact that pediatric gastrointestinal basidiobolomycosis is a rare infection, 76 cases of basidiobolomycosis have been reported in the English literature, mainly from Asia (69; 90%) [ 7 , 9 , 10 , 15 – 55 ]. So far, the Middle East has been the source of the majority of reported cases with Saudi Arabia reporting the highest number of pediatric basidiobolomycosis (34; 45%) followed by Iran (19; 24%) and India (8; 11%).…”

Section: Discussionmentioning

confidence: 99%

Disseminated Basidiobolomycosis Caused by Basidiobolus omanensis in a Child with Acute Lymphoblastic Leukemia (ALL). Case Report and Literature Review

Al Yazidi,

Al Sinani,

Al Adawi

et al. 2024

Mycopathologia

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Basidiobolomycosis is an uncommon fungal infection caused by the genus Basidiobolus. In immunocompetent children, it usually causes cutaneous infection and rarely affects the gastrointestinal tract, and it is extremely rare for the disease to spread. The present study reports the first case of disseminated basidiobolomycosis caused by Basidiobolus omanensis in a child with acute lymphoblastic leukemia who died as a result of uncontrolled infection and multi-organ failure despite surgical and antifungal therapy with L-AMB and voriconazole. A review of the literature yielded 76 cases, including the current case with the majority of which were reported as invasive gastrointestinal infection. The median age was 4 years (61 male and 15 female) and the majority of these children were from the Middle East (80%), specifically Saudi Arabia (45%). Most patients were treated with systemic antifungal agents (mostly itraconazole and amphotericin B). Surgical intervention was done in 25% of these patients and the death rate was 12%.

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“…12 A. fumigatus is also the most common etiologic agent of fungal sinusitis in immune competent individuals. Other fungal species reported to cause disease in this patient group include A. flavus, n A. niger, n Sporothrix schenckii, 1 Pseudallescheria boydii, s,9[0 Alternaria species, 2,21 Paecilomyces species, 20 Candida species," Basi-dobolus haptosporus, 6 Stemphylium mucorsporidium, 3 and Penicillium melinii? These fungi are common saprophytes, and infection is acquired by inhalation of fungal spores.…”

mentioning

confidence: 89%

Fungal Sinusitis in Healthy and Immunocompromised Individuals

Morgan

Wilson

Neel

et al. 1984

American Journal of Clinical Pathology

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Clinical and microbiologic aspects of fungal sinusitis occurring in six patients are presented. Three of the six patients were immunosuppressed. Fatal disseminated fungal disease developed in two of those immunosuppressed. The three patients with normal immune function had fungal infections confined to the nasal sinuses. Aspergillus fumigatus and Aspergillus flavus were recovered from the immunosuppressed patients and Sporothrix schenckii, Alternaria species, and Pseudallescheria boydii were recovered from the immunocompetent patients. Surgical debridement was performed on all patients; however, anti-fungal therapy only was prescribed in patients who were at risk of progressive fungal disease. The microbiology laboratory aids in the diagnosis of fungal sinusitis by examining surgical biopsy material for fungal organisms and by culturing the material for recovery of the fungal pathogen.

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Zygomycosis of the Maxillary Sinus and Palate Caused by

Cited by 49 publications

References 9 publications

Human Pathogenic Entomophthorales

Human Pathogenic Entomophthorales

Disseminated Basidiobolomycosis Caused by Basidiobolus omanensis in a Child with Acute Lymphoblastic Leukemia (ALL). Case Report and Literature Review

Fungal Sinusitis in Healthy and Immunocompromised Individuals

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