Zwitterionic electrospun PVDF fibrous membranes with a well-controlled hydration for diabetic wound recovery

Venault, Antoine; Lin, Kuan-Han; Tang, Shuo-Hsi; Hsu, Chen-Hua; Maggay, Irish Valerie; Chang, Yung

doi:10.1016/j.memsci.2019.117648

Cited by 50 publications

(24 citation statements)

References 69 publications

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“…As zwitterionic polymers have excellent antibiofouling abilities, they have also been used for wound-dressing purposes. [148] As an example, electrospun PCL membranes were functionalized with a zwitterionic polymer. To this system, halloysite nanotubes were HUVECs [188] like sustained drug carriers (Figure 13A) of the broad-spectrum antibiotic tetracycline hydrochloride.…”

Section: Skin Tissue Regenerationmentioning

confidence: 99%

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Toftdal

Friec

et al. 2021

Small Science

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Tissue regeneration is a rapidly evolving and interdisciplinary field at the intersection of life science, biology, material science, and engineering. Centrally, it involves functional cell-free or cell-laden constructs or biomaterial scaffolds that are fabricated utilizing various strategies. [1] Cell-free biomaterial scaffolds implanted directly at the sites of injury may mechanically support local cells to promote local tissue repair. [2] Furthermore, they can be functionalized both on the surface or in the interior with bioactive materials to stimulate regeneration of functional tissues. [3] In cell therapy applications, cell-laden constructs may enhance both survival and differentiation of the therapeutic cells compared with cell transplantation alone. The grafted cells may then ideally replace lost tissue and/or exert beneficial effects on the host tissue. [4] Among different biomaterial constructs, 3D fibrous scaffolds recreate a 3D microenvironment, which closely resembles the native extracellular matrix (ECM), including both structural and biochemical properties that guide cell survival and differentiation. [5] Scaffolds with fibrous networks possess unique characteristics, including sufficiently high interconnected porosity, high specific surface area, tunable mechanical properties, as well as optimal morphological features. The high porosity of the fibrous scaffolds facilitates mass transfer for effective nutrient supply, oxygen diffusion, metabolic waste removal, and enhancement of intercellular communications, consequently allowing high cell viability and function throughout the entire scaffold. [6] In addition, compared with 2D culture, the 3D cell culture provides a more realistic biochemical and biomechanical microenvironment, [7] creating an optimal environment for cell migration, proliferation, and differentiation. Hence, nanofibrous scaffolds with appropriate biomechanical properties are highly suitable for tissue engineering. [8] Electrospinning, as a relatively simple and versatile fiber preparation technique, has been developed to create fiber-based constructs in combination with cells, bioactive molecules, proteins, and biocompatible nanomaterials. [9] Many studies have demonstrated that the electrospinning technology has the potential for significant progress within the field of tissue regeneration. Chen et al. [10] summarized the methods for producing electrospun 1D nanofiber bundles, 2D

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Section: Skin Tissue Regenerationmentioning

confidence: 99%

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Toftdal

Friec

et al. 2021

Small Science

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“…As the largest organ of the human body, the skin acts as a barrier to several microorganisms such as bacteria and viruses and other contaminants such as foreign pollutants. 1,2 More importantly, it plays a vital role in the body's immune system. 3 Large-area trauma of the skin seriously affects the normal function of the body.…”

Section: Introductionmentioning

confidence: 99%

PLLA–gelatin composite fiber membranes incorporated with functionalized CeNPs as a sustainable wound dressing substitute promoting skin regeneration and scar remodeling

Sang

et al. 2022

J. Mater. Chem. B

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“…Additionally, skin displays a key role in the human body metabolic cycle [7,8]. Skin tissues possess an ability to be self-integrated [9][10][11][12]; however, a bacterial attack may retard this process [13][14][15][16]. Thus, the germicidal potential of biocomposites utilized in wound healing applications is a must [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nanofibrous Scaffolds of Ag/Vanadate Hydroxyapatite Encapsulated into Polycaprolactone: Morphology, Mechanical, and In Vitro Cells Adhesion

et al. 2021

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Series of nanofibrous composites of polycaprolactone (PCL) were fabricated in different compositions of modified hydroxyapatite (HAP). The encapsulated HAP was co-doped with Ag/vanadate ions at different Ag contributions. XRD and FTIR techniques confirmed the powder and fibrous phase formation. Further, the morphological and mechanical behaviors of the electrospun nanofibrous scaffolds containing hydroxyapatite were investigated. The nanofibrous phases were biologically evaluated via studying contact angle, antibacterial, cell viability, and in vitro growth of human fibroblasts cell line (HFB4). It is obvious that silver ions cause gradual deviation in powder grains from wafer-like to cloudy grains. The maximum height of the roughness (Rt) ranged from 902.0 to 956.9 nm, while the valley depth of the roughness (Rv) ranged from 308.3 to 442.8 nm, for the lowest and the highest additional Ag ions for powdered phases. Moreover, the highest contribution of silver through the nanofibrous phases leads to the formation of lowest filaments size ranged from 0.07 to 0.53 µm. Further, the fracture strength was increased exponentially from 2.51 ± 0.35 MPa at zero concentration of silver ions up to 4.23 ± 0.64 MPa at 0.6 Ag/V-HAP@PCL. The fibrous phases were biologically evaluated in terms of antibacterial, cell viability, and in vitro growth of human fibroblasts cell line (HFB4). The nanofibrous composition of 0.8 Ag/V-HAP@PCL reached the maximum potential against E. coli and S. aureus and recorded 20.3 ± 1.1 and 19.8 ± 1.2 mm, respectively. This significant performance of the antibacterial activity and cell viability of co-doped HAP distributed through PCL could recommend these compositions for more research in biological applications, including wound healing.

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Zwitterionic electrospun PVDF fibrous membranes with a well-controlled hydration for diabetic wound recovery

Cited by 50 publications

References 69 publications

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

PLLA–gelatin composite fiber membranes incorporated with functionalized CeNPs as a sustainable wound dressing substitute promoting skin regeneration and scar remodeling

Preparation and Characterization of Nanofibrous Scaffolds of Ag/Vanadate Hydroxyapatite Encapsulated into Polycaprolactone: Morphology, Mechanical, and In Vitro Cells Adhesion

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