Związek między polimorfizmem rs7903146 genu TCF7L2 a nefropatią cukrzycową nie jest niezależny od cukrzycy typu 2 — badanie populacji Indii Południowych i metaanaliza

Hussain, Hajarah; Ramachandran, Vinu; Ravi, Samathmika; Sajan, Teena; Ehambaram, Kiruthiha; Gurramkonda, Venkatesh Babu; Ramanathan, Gnanasambandan; Lakkakula, Bhaskar Vks

doi:10.5603/ep.2014.0041

Cited by 29 publications

(8 citation statements)

References 46 publications

(41 reference statements)

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“…As shown in Table 1 , a total of 56628 participants (34232 cases and 22396 controls) of 28 studies from 26 articles were included in this meta-analysis. The studies were divided into Caucasian (10 studies) [ 4 , 22 , 29 – 36 ], East Asian (5 studies) [ 23 , 25 , 37 – 39 ], South Asian (5 studies) [ 42 – 46 ] and Others (Arab (2 studies) [ 26 , 27 ], Black African (3 studies) [ 22 , 28 , 29 ] and Brazilian (3 studies) [ 24 , 40 , 41 ]) subgroups. The collected data, performed with the R package meta in this meta-analysis, was displayed in Additional file 1 : Table S2.…”

Section: Resultsmentioning

confidence: 99%

“…We used the keywords “rs7903146”, “type 2 diabetes” and “meta-analysis” to search in PubMed, and got nine articles [ 46 , 56 – 63 ]. Our work was different from others.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, we conducted a meta-analysis of published studies involving rs7903146 and T2DM to achieve a more comprehensive result. Finally, a total of 28 studies from 26 single studies [ 4 , 22 – 46 ] were collected to reevaluate the association between rs7903146 and T2DM.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

et al. 2018

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BackgroundLarge scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result.MethodsThe articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta.ResultsThe significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, p < 0.0001).ConclusionThe meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.Electronic supplementary materialThe online version of this article (10.1186/s12881-018-0553-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…We used the keywords “rs7903146”, “type 2 diabetes” and “meta-analysis” to search in PubMed, and got nine articles [ 46 , 56 – 63 ]. Our work was different from others.…”

Section: Discussionmentioning

confidence: 99%

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Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

et al. 2018

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“…Their study showed that in diabetic and nondiabetic ESRD patients, the T allele of rs7903146 increased the risk of developing DN. Hussain et al [32] concluded that this association was not independent of DM. A recent systematic meta-analysis and review of previous studies deduced that TCF7L2 may affect the risk of DN, and subgroup analysis showed that this association was consistent in both Asians and Caucasians, but not in Africans [33].…”

Section: Glucose Metabolism-related Genesmentioning

confidence: 99%

The Susceptibility Genes in Diabetic Nephropathy

Wei

Xiao

et al. 2018

Kidney Dis

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Background: Diabetes mellitus (DM) poses a severe threat to global public health. Diabetic nephropathy (DN) is one of the most common complications of diabetes and the leading cause of end-stage renal disease (ESRD). Approximately 30–40% of DM patients in the world progress to ESRD, which emphasizes the effect of genetic factors on DN. Family clustering also supports the important role of hereditary factors in DN and ESRD. Therefore, a large number of genetic studies have been carried out to identify susceptibility genes in different diabetic cohorts. Extensive susceptibility genes of DN and ESRD have not been identified until recently. Summary and Key Messages: Some of these associated genes function as pivotal regulators in the pathogenesis of DN, such as those related to glycometabolism and lipid metabolism. However, the functions of most of these genes remain unclear. In this article, we review several susceptibility genes according to their genetic functions to make it easier to determine their exact effect on DN and to provide a better understanding of the advancements from genetic studies. However, several challenges associated with investigating the genetic factors of DN still exist. For instance, it is difficult to determine whether these variants affect the expression of the protein they encode or other cytokines. More efforts should be made to determine how these genes influence the progression of DN. In addition, many results could not be replicated among races, suggesting that the association between genetic polymorphisms and DN is race-specific. Therefore, large, well-designed studies involving more relevant variables and ethnic groups and more relevant functional studies are urgently needed. These studies may be beneficial and retard the progression of DN by early intervention, especially for patients who carry certain risk alleles or genotypes.

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“…The minor allele frequencies were 3815 in DN group, 4303 in control group, total allele frequencies were 11,698 in DN group, and 16,034 in control group. Of the 7 studies, there were three 19 , 32 , 35 with Asian ethnicity, two 21 , 33 with Caucasian ethnicity, two 34 , 36 with Negroid, respectively. Six articles 21 , 32 – 36 probed the association of rs7903146 mutation and DN risk.…”

Section: Resultsmentioning

confidence: 99%

Association of the Transcription Factor 7 Like 2 (TCF7L2) Polymorphism With Diabetic Nephropathy Risk

Fan

Cai

Chen³

et al. 2016

Medicine

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It is assumed that genetic factors may participate in the development of diabetic nephropathy (DN). The association between TCF7L2 gene polymorphism and DN risk is still unclear. To evaluate the relationship, we performed this meta-analysis.Eligible relevant studies were searched and selected from PubMed, Embase, and ISI Web of Science. Summary effect estimates were derived using a random effects model, with attention to study quality and publication bias. Ethnical approval was not necessary, because this meta-analysis was based on published articles, and did not involve patient consent.A total of 7 studies were identified. Analysis of all studies indicated significant association between TCF7L2 gene polymorphism and DN risk (odds ratio [OR] = 1.31, 95% confidence interval (CI) = 1.10–1.56, Pheterogeneity < 0.00001, P = 0.002). Subgroup analysis showed similar results in Asian (OR = 1.33, 95% CI = 1.10–1.62, Pheterogeneity = 0.03, P = 0.004), in Caucasian (OR = 2.27, 95% CI = 1.78–2.90, Pheterogeneity = 0.17, P < 0.00001), in rs7903146 mutation (OR = 1.61, 95% CI = 1.25–2.07, Pheterogeneity < 0.00001, P = 0.0002), However, no association was observed in Negroid (OR = 1.10, 95% CI = 0.90–1.35, Pheterogeneity < 00001, P = 0.36).Our results suggest that TCF7L2 gene polymorphism may contribute to the risk of DN. However, more studies should be launched in the future.

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Związek między polimorfizmem rs7903146 genu TCF7L2 a nefropatią cukrzycową nie jest niezależny od cukrzycy typu 2 — badanie populacji Indii Południowych i metaanaliza

Cited by 29 publications

References 46 publications

Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

The Susceptibility Genes in Diabetic Nephropathy

Association of the Transcription Factor 7 Like 2 (TCF7L2) Polymorphism With Diabetic Nephropathy Risk

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