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Jones, Jones

doi:10.1016/s1076-0512(98)00048-x

Cited by 13 publications

(2 citation statements)

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“…At least 10% of tumors contain elements of more than one subtype (Carr et al 2007; Jones et al 1998; Rippey 1998), and dermatopathologists often classify BCCs according to which histologic pattern is present in the bulk of the tumor. Generally the histology of a BCC does not change over time, although with recurrence, more aggressive BCC may be noted.…”

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confidence: 99%

Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype

Heffelfinger

Ouyang

Engberg

et al. 2012

G3 Genes|Genomes|Genetics

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Basal cell carcinomas (BCCs) are the most common cancers in the United States. The histologic appearance distinguishes several subtypes, each of which can have a different biologic behavior. In this study, global miRNA expression was quantified by high-throughput sequencing in nodular BCCs, a subtype that is slow growing, and infiltrative BCCs, aggressive tumors that extend through the dermis and invade structures such as cutaneous nerves. Principal components analysis correctly classified seven of eight infiltrative tumors on the basis of miRNA expression. The remaining tumor, on pathology review, contained a mixture of nodular and infiltrative elements. Nodular tumors did not cluster tightly, likely reflecting broader histopathologic diversity in this class, but trended toward forming a group separate from infiltrative BCCs. Quantitative polymerase chain reaction assays were developed for six of the miRNAs that showed significant differences between the BCC subtypes, and five of these six were validated in a replication set of four infiltrative and three nodular tumors. The expression level of miR-183, a miRNA that inhibits invasion and metastasis in several types of malignancies, was consistently lower in infiltrative than nodular tumors and could be one element underlying the difference in invasiveness. These results represent the first miRNA profiling study in BCCs and demonstrate that miRNA gene expression may be involved in tumor pathogenesis and particularly in determining the aggressiveness of these malignancies.

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confidence: 99%

Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype

Heffelfinger

Ouyang

Engberg

et al. 2012

G3 Genes|Genomes|Genetics

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“…[1819] It presents with different pathologic features and has specific anatomical site distribution. [202122] One of the frequent histopathologic features of the tumor is mixed type BCC.…”

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confidence: 99%

Characteristics of mixed type basal cell carcinoma in comparison to other BCC subtypes

et al. 2014

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Background:There are limited data exploring the characteristics of mixed type basal cell carcinoma (BCC).Objectives:To explore different characteristics of mixed type BCC.Design:Cross sectional study.Materials and Methods:825 patients with BCC enrolled in this study.Results:Among 825 patients, 512 (62%) were male. Three hundred and fifty five (43%) presented with nodular subtype, 267 (32.4%) with mixed subtype, 25 with superficial and the 178 remaining presented with other subtypes. Four hundred and eighty three (58.6%) of the lesions were on the face, 243 (29.5%) on scalp, 52 (6.3%) on ears, 20 (2.4%) on neck, 15 (1.8%) on trunk and 12 (1.4%) on extremities. Anatomic distribution of mixed type was as follows: 137 on face, (51.4%), 100 (37.3%) on scalp, 19 (7%) on ear, 6 (2.1%) on neck, 4 (1.5%) extremity and 1 (0.7%) on trunk, which the difference from non mixed types was statistically significant (P = 0.002). The mean diameter of the mixed types and non mixed type BCCs were significantly different (2.7 ± 2.1 cm vs. 2.2 ± 1.6 cm; P = 0.01. The prevalence of necrosis in mixed type BCC was two times higher than non mixed type BCCs (OR = 2.3, CI 95% 1.3-3.9, P = 0.001). The most frequent combined subtypes were nodular-infiltrative (P < 0.001).Conclusion:Mixed type BCC has differences with other BCC subtypes in anatomical distribution and tumor diameter. Indeed, mixed type BCCs are frequently composed of aggressive subtypes than nonaggressive subtypes.

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