Zusammenfassende Betrachtungen über die erblichen Blutstrukturen des Menschen

Bernstein, Felix

doi:10.1007/bf01763333

Cited by 91 publications

(35 citation statements)

References 11 publications

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“…His training was in mathematics rather than medicine, but he achieved fame for having resolved the genetics of the A, B, AB, and O blood groups, discovered by Landsteiner who also published in German (Gottlieb 1998;Bernstein 1925). Familiarity with the ABO system is essential for every medical student and was so when it was believed that the human genome had 48 chromosomes (Crew 1947).…”

Section: Context and Backgroundmentioning

confidence: 99%

Wilhelm Weinberg’s Early Contribution to Segregation Analysis

Stark

Seneta

2013

Genetics

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Wilhelm Weinberg (1862-1937) is a largely forgotten pioneer of human and medical genetics. His name is linked with that of the English mathematician G. H. Hardy in the Hardy-Weinberg law, pervasive in textbooks on population genetics since it expresses stability over generations of zygote frequencies AA, Aa, aa under random mating. One of Weinberg's signal contributions, in an article whose centenary we celebrate, was to verify that Mendel's segregation law still held in the setting of human heredity, contrary to the then-prevailing view of William Bateson (1861Bateson ( -1926, the leading Mendelian geneticist of the time. Specifically, Weinberg verified that the proportion of recessive offspring genotypes aa in human parental crossings Aa · Aa (that is, the segregation ratio for such a setting) was indeed p ¼ 1 4 . We focus in a nontechnical way on his procedure, called the simple sib method, and on the heated controversy with Felix Bernstein in the 1920s and 1930s over work stimulated by Weinberg's article.

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Section: Context and Backgroundmentioning

confidence: 99%

Wilhelm Weinberg’s Early Contribution to Segregation Analysis

Stark

Seneta

2013

Genetics

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“…The Mendelian basis for the inheritance of naturally occurring discrete polymorphisms, such as the ABO blood groups of humans (Bernstein, 1925), Batesian mimics in Papilio butterflies (Punnett, 1915) and heterostyly in Primula (Bateson & Gregory, 1905), was quickly established. However, discrete variation that is easily detectable at the phenotypic level is comparatively uncommon, except for rare deleterious mutations.…”

Section: Introductionmentioning

confidence: 99%

Molecular population genomics: a short history

Charlesworth

2010

Genet. Res.

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SummaryPopulation genomics is the study of the amount and causes of genome-wide variability in natural populations, a topic that has been under discussion since Darwin. This paper first briefly reviews the early development of molecular approaches to the subject : the pioneering unbiased surveys of genetic variability at multiple loci by means of gel electrophoresis and restriction enzyme mapping. The results of surveys of levels of genome-wide variability using DNA resequencing studies are then discussed. Studies of the extent to which variability for different classes of variants (non-synonymous, synonymous and non-coding) are affected by natural selection, or other directional forces such as biased gene conversion, are also described. Finally, the effects of deleterious mutations on population fitness and the possible role of Hill-Robertson interference in shaping patterns of sequence variability are discussed.

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“…Several authors have already developed formulae for estimating gene frequency in the ABO blood groups (Bernstein, 1925;Wiener et al, 1929;Stevens, 1938;Fisher, 1946;Yasuda and Kimura, 1968). Although recent advents of electronic computer have made it feasible to calculate the ABO gene frequency as the maximum likelihood solution, a simple and biologically sound formula may be still of use.…”

Section: Introductionmentioning

confidence: 99%

A note on gene frequency estimation in the ABO and ABO-like system

Yasuda¹

1984

Jap J Human Genet

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SummaryBased on a random sample of individuals, new conventional formulae for estimating gene frequency in the ABO and the ABO-like system are presented. Applying the formulae on a large number of samples, it is found that the new method is simple and yields estimates as accurate in at least two decimal places as the maximum likelihood solutions. The method however might be fraught with bias when the O phenotype frequency was low or even absent. Degrees of this bias have been discussed in terms of the number of iterative processes by a method of gene counting and of a goodness of fit to the Hardy-Weinberg proportions.

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Zusammenfassende Betrachtungen über die erblichen Blutstrukturen des Menschen

Cited by 91 publications

References 11 publications

Wilhelm Weinberg’s Early Contribution to Segregation Analysis

Wilhelm Weinberg’s Early Contribution to Segregation Analysis

Molecular population genomics: a short history

A note on gene frequency estimation in the ABO and ABO-like system

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