Zur Weiterentwicklung synthetisch dargestellter Malariamittel

Kikuth, Walter

doi:10.1055/s-0028-1122899

Cited by 29 publications

(10 citation statements)

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“…It acts prophylactically against blood-inoculated infections, delaying the onset of the attack, but does not sterilise the bird of parasites. These observations agree with those of Kikuth (1932).…”

Section: Discussionsupporting

confidence: 93%

“…THE first tests of the synthetic anti-malarial drug atebrin were made by Kikuth (1932) on canaries infected with Plasmodium relictum, and on Java sparrows infected with Haemoproteus orizivorae. Using the method of Roehl (1926) he found that atebrin had a chemotherapeutic index of 1: 30 when employed in infections due to Plasmodium relictum.…”

Section: Introductionmentioning

confidence: 99%

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The Action of Atebrin on Bird Malaria

Täte

Vincent

1934

Parasitology

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1. Atebrin given during the incubation period delays the appearance of parasites in the blood of birds infected by direct blood inoculation with Plasmodium relictum.2. If given to birds infected by the bites of mosquitoes it does not retard the appearance of parasites in the blood, when given either before, or after, the infective bites, but it has some action in diminishing the severity of the attack and the degree of splenic enlargement.3. Parasites appear in the blood of birds, infected by sporozoites, actually during the course of atebrin treatment if this is prolonged beyond the normal incubation period.4. When asexual parasites appear in the blood of mosquito-infected birds after atebrin treatment they are abnormal in appearance and devoid of pigment grains; gametocytes are rarely seen in the blood of such birds, but if present they have normal pigment granules.5. Treatment with atebrin produces peculiar bodies in the blood cells of canaries.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Action of Atebrin on Bird Malaria

Täte

Vincent

1934

Parasitology

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“…reported P. rouxi in the blood of a partridge from Delhi, India, recorded P. polare from the same host and locality. Amongst the early discovered species of avian Plasmodium, P. vaughani (Novy and Mac Neal 1904), P. cathemerium (Hartman 1927), P. rouxi (Sergent and Catanei 1928) and P. circumflexum (Kikuth 1931) are noteworthy. P. vaughani and P. circumflexum were described by Laird and Lari (1956) and Laird (1962).…”

Section: Discussionmentioning

confidence: 98%

New records of Haemoproteus and Plasmodium (Sporozoa: Haemosporida) of rock pigeon (Columba livia) in India

2011

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The prevalence, intensity and morpho-variants of new species of haemosporida (Haemoproteus and Plasmodium) from the rock pigeon, Columba livia are described and illustrated for the first time from Uttar Pradesh state of India. Thin blood smears from 266 C. livia indicated 55.63% (Haemoproteus) and 6.76% (Plasmodium) prevalence and 1-6 pars/100 RBC's (Haemoproteus) and 1-2 pars/100 RBC's (Plasmodium) intensity of infection. The fully grown intracellular gametocytes of Haemoproteus were differentiated into microgametocyte (14.0 × 4.3 μm) and macrogametocyte (13.9 × 4.7 μm). Extracorpuscular gametocyte (15.0-17.8 μm in length, 3.9-7.3 μm in width) were occasionally visible. Nuclear displacement ratio was 0.2. Plasmodium species was characterized by rounded schizonts and elongated microgametocyte (7.8 × 7.6 μm) and macrogametocyte (7.8 × 7.7 μm) with irregular margins. Cells containing schizonts are often rounded and enlarged and those parasitized by gametocytes may be somewhat distorted in shape by lateral hypertrophy. Host cell nuclei are also displaced. Double gametocyte infection of Haemoproteus occasionally present but that of Plasmodium lacking.

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“…Atebrin was the first synthetic antimalarial to have substantial activity against the asexual stages of the parasites that cause human malaria (Kikuth, 1932). Since it is eliminated much more slowly than QN, its treatment course is shorter than that of QN.…”

Section: Anything Other Than Quinine?mentioning

confidence: 99%

The chequered history of malaria control: are new and better tools the ultimate answer?

Rieckmann

2006

Annals of Tropical Medicine & Parasitology

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Following Ronald Ross' demonstration in 1897 that mosquitoes transmit malarial parasites, efforts to control malaria were naturally focussed on attacking the mosquito vector by various measures, mainly directed against the aquatic stages. Although the results were spectacular in some areas, there was a growing realisation that effective control of malaria depended on other factors, including the availability of better drugs than quinine and a greater understanding of the epidemiology of the disease under various environmental conditions. With the discovery of DDT, an all-out effort was made to eradicate malaria by attacking adult mosquitoes. Eradication was not achieved in many countries, mainly because of inadequate health infrastructures. With the emergence of chloroquine-resistant parasites, the search for more effective drug regimens intensified, various drugs and drug combinations were assessed, and methods were developed to monitor and assess degrees of resistance. Since resistance to drugs can develop very quickly, the use of drug combinations, especially those containing artemisinin derivatives, is now recommended. Insecticide-impregnated bednets have become the preferred method of vector control. Although the search for better tools must continue, the events of the past century emphasise the need to strengthen health systems to ensure that they are capable of delivering effective interventions and of assessing their effectiveness in controlling malaria.

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Zur Weiterentwicklung synthetisch dargestellter Malariamittel

Cited by 29 publications

References 0 publications

The Action of Atebrin on Bird Malaria

The Action of Atebrin on Bird Malaria

New records of Haemoproteus and Plasmodium (Sporozoa: Haemosporida) of rock pigeon (Columba livia) in India

The chequered history of malaria control: are new and better tools the ultimate answer?

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