Zur Validität der deutschen Fassung der ADOS-2 unter                     Berücksichtigung von Geschlechtseffekten

Kamp‐Becker, Inge; Langmann, Anika; Stehr, Thomas; Custodis, Katharina; Poustka, Luise; Becker, Katja

doi:10.1024/1422-4917/a000492

Cited by 8 publications

(1 citation statement)

References 37 publications

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“…Groups were matched for age, sex, and full-scale IQ (FSIQ; see Table 1 ). ASD was assessed using gold-standard diagnostic tools, i.e., the German version of the Autism Diagnostic Interview-Revised (ADI-R; [ 29 , 30 ]) and the second edition of the Autism Diagnostic Observation Schedule (ADOS-2; [ 31 , 32 ]). Repetitive behaviors were examined in all participants using the German version of the Repetitive Behavior Scale-Revised (RBS-R) at both assessment timepoints [ 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

Longitudinal Changes in Cortical Thickness in Adolescents with Autism Spectrum Disorder and Their Association with Restricted and Repetitive Behaviors

Bieneck

Bletsch

Mann

et al. 2021

Genes

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The neuroanatomy of autism spectrum disorder (ASD) shows highly heterogeneous developmental trajectories across individuals. Mapping atypical brain development onto clinical phenotypes, and establishing their molecular underpinnings, is therefore crucial for patient stratification and subtyping. In this longitudinal study we examined intra- and inter-individual differences in the developmental trajectory of cortical thickness (CT) in childhood and adolescence, and their genomic underpinnings, in 33 individuals with ASD and 37 typically developing controls (aged 11–18 years). Moreover, we aimed to link regional atypical CT development to intra-individual variations in restricted and repetitive behavior (RRB) over a two-year time period. Individuals with ASD showed significantly reduced cortical thinning in several of the brain regions functionally related to wider autism symptoms and traits (e.g., fronto-temporal and cingulate cortices). The spatial patterns of the neuroanatomical differences in CT were enriched for genes known to be associated with ASD at a genetic and transcriptomic level. Further, intra-individual differences in CT correlated with within-subject variability in the severity of RRBs. Our findings represent an important step towards characterizing the neuroanatomical underpinnings of ASD across development based upon measures of CT. Moreover, our findings provide important novel insights into the link between microscopic and macroscopic pathology in ASD, as well as their relationship with different clinical ASD phenotypes.

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Section: Methodsmentioning

confidence: 99%

Longitudinal Changes in Cortical Thickness in Adolescents with Autism Spectrum Disorder and Their Association with Restricted and Repetitive Behaviors

Bieneck

Bletsch

Mann

et al. 2021

Genes

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Diagnostic accuracy of the ADOS and ADOS-2 in clinical practice

Kamp‐Becker

Albertowski

Becker

et al. 2018

Eur Child Adolesc Psychiatry

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The Autism Diagnostic Observation Schedule is a semi-structured, standardized assessment tool for individuals with suspected autism spectrum disorders (ASD) and is deemed to be part of the gold standard for diagnostic evaluation. Good diagnostic accuracy and interpersonal objectivity have been demonstrated for the ADOS in research setting. The question arises whether this is also true for daily clinical practice and whether diagnostic accuracy depends on specialized experience in the diagnostic evaluation. The present study explores the diagnostic accuracy of the original and the revised version of the ADOS for Modules 1 through 4. Thus, seven cases of ADOS executions were recorded and coded by a group of experts of specialized outpatient clinics for ASD. In an extensive consensus process, including video analysis of every minute of the ADOS executions, a "gold standard" coding for every case was defined. The videos of the ADOS administration were presented to a large group of clinicians (from daily clinical routine care) and their codings (n = 189) were obtained and analysed. Variance of coding and congruence with the expert coding were determined. High variance was found in the codings. The accuracy of the coding depends on the experience of the coder with the ADOS as well as on characteristics of the cases and the quality of the administration of the ADOS. Specialization in the diagnostic of ASD has to be claimed. Specialized outpatient clinics for ASD are required which guarantee a qualified diagnostic/differential diagnostic and case management with the aim of demand-oriented supply of individual cases.

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Differentiating Autism from ADHD in Children and Adolescents Using BASC-3

Zhou

Reynolds

Zhu

et al. 2020

J Pediatr Neuropsychol

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Zur Validität der deutschen Fassung der ADOS-2 unter Berücksichtigung von Geschlechtseffekten

Abstract: Good diagnostic accuracy was found for children in the average range of cognitive abilities. Results suggest good diagnostic utility for the ADOS-2 in clinical settings, provided that thorough diagnostics are given by experienced examiners.

Cited by 8 publications

References 37 publications

Longitudinal Changes in Cortical Thickness in Adolescents with Autism Spectrum Disorder and Their Association with Restricted and Repetitive Behaviors

Longitudinal Changes in Cortical Thickness in Adolescents with Autism Spectrum Disorder and Their Association with Restricted and Repetitive Behaviors

Diagnostic accuracy of the ADOS and ADOS-2 in clinical practice

Differentiating Autism from ADHD in Children and Adolescents Using BASC-3

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