Zur Physiologie und Pathophysiologie der Porphyrin-Ausscheidung

Schreus, H. Th.; Carrié, C.

doi:10.1007/bf02352481

Cited by 24 publications

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“…The symptoms of acute porphyria and perhaps also of lead poisoning (Schreus, 2464) are due to different toxic actions of porphyrin, which do not depend on light. Porphyrins have been found to cause vascular spasms {1025, 2212,2348,2469,2707,2850) as well as intestinal spasms {2229, 2464,2707,2850). They also probably cause the psychiatric disorders which frequently accompany acute porphyria {406, 556,655,1070,1552,2349,2848,2850,2908); Baker and Watson {116) observed pathologic alterations of the myelin sheath in this disease.…”

Section: Porphyrin Formation From Other Hematin Compoundsmentioning

confidence: 99%

“…The porphyrin of the chick embryo is formed during a stage at which little hemoglobin and probably no bile pigment is present and can hardly be formed by hemoglobin breakdown (Sch0nheyder, 2458) ; in the frequently quoted paper of Sendju (2530), bile pigment formation in the chick embryo had been studied by the entirely unreliable method of iodine titration. Schreus and Carrie (2469) claimed that intravenous injection of hemoglobin caused porphyrinuria, but Duesberg (639) found no increase of porphyrin excretion after hemoglobin injection or after hemolysis caused by injection of distilled water or saponin. Thomas {2798) also failed to notice any increase of total porphyrin excretion in the rat by hemoglobin injection or intravascular hemolysis.…”

Section: Synthesismentioning

confidence: 99%

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Hematin compounds and bile pigments; their constitution, metabolism, and function, by R. Lemberg and J.W. Legge.

Legge¹,

Lemberg²

1949

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II. METHODS or INVESTIGATION* Only the naturally occurring hile pigments of type IXa are discussed.* .\11 tlie al).s()r[)ti()ii curves of the "hiliverdiiis" in Heihiieyers hook (121-i) are ohviously tliose of niixtiirt's of liiliverditi witli hiliruliiii (pages 1(51, 1()7) and other * The term K-urobilin is, however, used by the Fischer school to denote a mixture of side chain isomerides of mesobilene-(b) in contradistinction to mesobilene-(b) IXa.* It is not certain, however, whether the albumin is the only plasma protein able to combine with hematin (c/. Miller and Ailing, 191f9a).* Keilin and Smith {1502a) have been unable to confirm the results of Virtanen and Laine.XII. HEMOGLOBIN CATABOLISM, II * Cf., however, Bittner and Watson {28-3a). CHAPTER XIII FORMATION OF HEMOGLOBIN AND SYNTHESIS OF PORPHYRINSIN THE ANIMAL BODY * The hemoglobin found occasionally in some species of Daphnia (Fox,937aa) does not appear to have an essential physiologic function, although, like the hematin compounds mentioned above, it is passed on in parthenogenetic eggs. Even the chlorocruorin or erythrocruorin of serpulimorphid worms does not appear to be essential (Fox, 937a).Glaucobilin. See Mesobiliverdin. Globan, 211. See also Globin (denatured). Globin, denatured, 240, 258 combination with heme, 232 electrometric titration, 255 in erythrocytes, 525 isoelectric point, 255 renaturation, 259 Globin, native, 230, 258, 568 amino acids. See Hemoglobin. combination, with hematins, 239 with metalloporphyrins, 240 with porphyrins, 240 denaturation, 255 ff. 734 SUBJECT INDEX Globin native (contd.) electrometric titration, 255 differential of globin and hemiglobin, 244 fate in hemogIol>in breakdown, 548, 568 frictional ratio, 250 isoelectric point, 255 molecular weight, 250 oxidation, in autoxidation of hemoglobin, 390 in denaturation, 395, 478 preparation, 258 specificity, 321. See also Hemoglobin. synthesis in vivo, 610 Glutathione as anticatalase, 412 and choleglobin formation, 477, 478, 517 and dehydroascorbic acid, 470, 517, 518 in erythrocyte, 516, 522, 619 and hem/globin, 522 as substrate of cytochrome c, 376 Glycine, in porphyrin s\nthesis, 637 Gmelin reaction, 109, 112 (table), 116, 138 Green hemins, 201, 456, 490. See also Chlorophyll hemins, Pheophorbide kemin, Verdochemochrome.

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